Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study

Iacucci, Marietta; Jeffery, Louisa; Acharjee, Animesh; Grisan, Enrico; Buda, Andrea; Nardone, Olga M; Smith, Samuel C L; Labarile, Nunzia; Zardo, Davide; Ungar, Bella; Hunter, Stuart; Mao, Ren; Cannatelli, Rosanna; Shivaji, Uday N; Parigi, Tommaso Lorenzo; Reynolds, Gary M; Gkoutos, Georgios V; Ghosh, Subrata

doi:10.1093/ibd/izac233

Computer-Aided Imaging Analysis of Probe-Based Confocal Laser Endomicroscopy With Molecular Labeling and Gene Expression Identifies Markers of Response to Biological Therapy in IBD Patients: The Endo-Omics Study

Background We aimed to predict response to biologics in inflammatory bowel disease (IBD) using computerized image analysis of probe confocal laser endomicroscopy (pCLE) in vivo and assess the binding of fluorescent-labeled biologics ex vivo. Additionally, we investigated genes predictive of anti-…