Cited by 9Inflammatory Bowel DiseaseSmoking Behavior and CessationGenetic Associations and Epidemiology

Smoking Interacts With CHRNA5, a Nicotinic Acetylcholine Receptor Subunit Gene, to Influence the Risk of IBD-Related Surgery

Open access
Cushing, Kelly C, Chiplunker, Adeeti, Li, Allie, Sung, Yun Ju, Geisman, Taylor, Chen, Li-Shiun, Cresci, Sharon, Gutierrez, Alexandra M·2018·Inflammatory Bowel Diseases

Abstract

Background: Inflammatory bowel disease (IBD) is a chronic luminal disease with genetic and environmental factors affecting phenotype.This study evaluated the relationship between CHRNA5, a nicotinic receptor subunit gene, and smoking in predicting IBD-related surgery as well as the relationship between CHRNA5 and nicotine dependence.Methods: Participants completed a smoking questionnaire and were genotyped for CHRNA5 rs16969968.Demographic and clinical data were obtained from medical records.Wilcoxon, ANOVA, Chi square, and Fisher's exact tests were used for comparisons.Logistic regression was used to evaluate the effect of clinical and genetic predictors on surgery, stratified by disease subtype given paradoxical effects of smoking.Kaplan-Meier curves were used to examine the effect of smoking and genotype on time to surgery.(Significance: P < 0.05 for main effects; P < 0.2 for interaction terms) Results: 400 (65.8%) patients had Crohn's disease (CD) and 208 (34.2%) had ulcerative colitis (UC).298 (49%) underwent an IBD-related surgery.There was a trend towards significance between rs16969968 and smoking behavior (smoking status [P = 0.05], nicotine dependence [AA > AG > GG; P = 0.08]).Smoking and genotype were not independently associated with surgery in UC or CD.However, interaction between rs16969968 and smoking in predicting surgery was observed for both UC (OR = 2.72; P = 0.05) and CD (OR = 2.88; P = 0.1).CHRNA5 genotype, but not smoking, predicted time to surgery in patients with UC (P = 0.007) but not in patients with CD.The interaction between smoking and genotype was not significantly associated with time to surgery in UC or CD. Conclusions:The CHRNA5 rs16969968 A variant interacts with smoking to influence IBD-related surgery.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/ibd/izx094

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 33 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Cushing, K. C., Chiplunker, A., Li, A., Sung, Y. J., Geisman, T., Chen, L.-S., Cresci, S., & Gutierrez, A. M.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Cushing, Kelly C
Venue
Inflammatory Bowel Diseases
Published
2018-02-23
Volume
24
Issue
5
Pages
1057-1064
ISSN
  • 1078-0998 (ISSN-L)
  • 1536-4844
OpenAlex
W4254402385
Cited by
9
References
33
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2019: 1
FWCI
0.15
Type
journal article
Language
en
Open access
Locations
  • Inflammatory Bowel Diseases (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
Funders
  • National Institutes of Health (T32DK007130)
  • Washington University Institute of Clinical and Translational Sciences (UL1TR000448)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
CHRNA5, nicotinic acetylcholine receptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review