Cited by 416Inflammatory Bowel DiseaseHealth Systems, Economic Evaluations, Quality of LifeOcular Diseases and Behçet’s Syndrome

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Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part II

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Knowles, Simon R, Keefer, Laurie, Wilding, Helen, Hewitt, Catherine, Graff, Lesley A, Mikocka-Walus, Antonina·2018·Inflammatory Bowel Diseases

DOI 10.1093/ibd/izy015

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Abstract

Background: There has been burgeoning interest in quality of life (QoL) in inflammatory bowel disease (IBD) in recent decades, with hundreds of studies each year now assessing this outcome. This paper is part 2 of a systematic review evaluating 5 key QoL comparisons within IBD states and relative to others without IBD. Part 1 examined QoL comparing IBD and a healthy/general population and other medically ill groups. Part 2, presented here, examines within-disease comparisons of active/inactive disease, Ulcerative colitis (UC) / Crohn's disease (CD), and change in QoL over time. Outcomes using generic versus IBD-specific QoL measures were also examined. Methods: Adult and pediatric studies were identified through systematic searches of 7 databases from the 1940s (where available) to October 2015. Results: Of 6173 abstracts identified, 466 were selected for final review based on controlled design and validated measurement, of which 83 unique studies (75 adult, 8 pediatric) addressed the within-disease comparisons. The pooled mean QoL scores were significantly lower in active versus inactive IBD (n = 26) and for those with CD versus UC (n = 37), consistent across IBD-specific and generic QoL measures, for almost all comparisons. There was significant improvement in QoL over time (n = 37). Study quality was generally low to moderate. The most common measures of QoL were the disease-specific Inflammatory Bowel Disease Questionnaire and generic 36-Item Short Form Survey (SF-36) (adults) and the IBD-specific IMPACT (children). Conclusions: For adults in particular, there was strong confirmation that QoL is poorer during active disease and may be poorer for those with CD. The finding that QoL can improve over time may be encouraging for individuals with this chronic disease.

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Authors: Knowles, S. R., Keefer, L., Wilding, H., Hewitt, C., Graff, L. A., & Mikocka-Walus, A.
Affiliations: The Royal Melbourne Hospital (AU)
Icahn School of Medicine at Mount Sinai (US)
St Vincent's Hospital Melbourne (AU)
University of York (GB)
University of Manitoba (CA)
Department of Health Sciences, University of York, York, United Kingdom
Corresponding author: Knowles, Simon R
ORCID: Knowles, Simon R
Keefer, Laurie
Wilding, Helen
Hewitt, Catherine
Graff, Lesley A
Venue: Inflammatory Bowel Diseases
Publisher: Oxford University Press (OUP)
Published: 2018-04-23
Volume: 24
Issue: 5
Pages: 966-976
ISSN: 1078-0998 (ISSN-L)
1536-4844
DOI: 10.1093/ibd/izy015
OpenAlex: W2801602793
Cited by: 416
References: 146
Citations by year: 2026: 26 · 2025: 53 · 2024: 73 · 2023: 83 · 2022: 55 · 2021: 61 · 2020: 35 · 2019: 24 · 2018: 6
FWCI: 4.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/about_us/legal/notices (vor)
Locations: Inflammatory Bowel Diseases (publishedVersion)
PubMed (publishedVersion)
Own your potential (DEAKIN) (submittedVersion)
Figshare (submittedVersion, cc-by)
Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: quality of life, inflammatory bowel disease
MeSH terms: Adult, Child, Colitis, Ulcerative, Crohn Disease, Humans, Quality of Life, Surveys and Questionnaires

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Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part II

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