The DOI matches its Crossref record; 144 of the 146 references it cites were found in a registry or an index.
Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part II
Open accessAbstract
Background: There has been burgeoning interest in quality of life (QoL) in inflammatory bowel disease (IBD) in recent decades, with hundreds of studies each year now assessing this outcome. This paper is part 2 of a systematic review evaluating 5 key QoL comparisons within IBD states and relative to others without IBD. Part 1 examined QoL comparing IBD and a healthy/general population and other medically ill groups. Part 2, presented here, examines within-disease comparisons of active/inactive disease, Ulcerative colitis (UC) / Crohn's disease (CD), and change in QoL over time. Outcomes using generic versus IBD-specific QoL measures were also examined. Methods: Adult and pediatric studies were identified through systematic searches of 7 databases from the 1940s (where available) to October 2015. Results: Of 6173 abstracts identified, 466 were selected for final review based on controlled design and validated measurement, of which 83 unique studies (75 adult, 8 pediatric) addressed the within-disease comparisons. The pooled mean QoL scores were significantly lower in active versus inactive IBD (n = 26) and for those with CD versus UC (n = 37), consistent across IBD-specific and generic QoL measures, for almost all comparisons. There was significant improvement in QoL over time (n = 37). Study quality was generally low to moderate. The most common measures of QoL were the disease-specific Inflammatory Bowel Disease Questionnaire and generic 36-Item Short Form Survey (SF-36) (adults) and the IBD-specific IMPACT (children). Conclusions: For adults in particular, there was strong confirmation that QoL is poorer during active disease and may be poorer for those with CD. The finding that QoL can improve over time may be encouraging for individuals with this chronic disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Inflammatory bowel disease (IBD) considerably impacts the quality of life and raises the risk of developing mental health problems (Knowles et al., 2018).”
From Randomized controlled trial of an Acceptance and Commitment Therapy and compassion-based group intervention for persons with inflammatory bowel disease: the LIFEwithIBD intervention (2024) · cites this paper as Knowles et al., 2018
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Our meta-analyses found that people with IBD experience a consistently poor quality of life (QoL) both during disease flare-ups and remission.6 7”
From Acceptance commitment therapy (ACT) for psychological distress associated with inflammatory bowel disease (IBD): protocol for a feasibility trial of the ACTforIBD programme (2022) · cites this paper as [6]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Wan, X., Wang, W., Liu, J., & Tong, T. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-135 · Cited by 11,735
Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment
THE WHOQOL GROUP (1998) · Psychological Medicine · doi:10.1017/s0033291798006667 · Cited by 7,933
Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.001 · Cited by 4,833
Sanderson, S., Tatt, I. D., & Higgins, J. P. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym018 · Cited by 1,531
A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease
Guyatt, G., Mitchell, A., Irvine, E. J., Singer, J., Williams, N., Goodacre, R. L., & Tompkins, C. (1989) · Gastroenterology · doi:10.1016/s0016-5085(89)80080-0 · Cited by 1,289
Is quality of life determined by expectations or experience?
Carr, A., Gibson, B., & Robinson, P. G. (2001) · BMJ · doi:10.1136/bmj.322.7296.1240 · Cited by 844
Flagged first, then by citations
2 of the 146 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Tragnone, 1996, Quality of life and inflammatory bowel disease, Gastroenterol, 9, 47
Cited by
Sorted by citations
Items 401–415 of 415
Méndez, J. E. P., Cheng, H. G. C., Azañedo, C., Franco-Vásquez, R. A., Plata, A. L. M. R., Pérez, S. I. J., & Marcacuzco, H. T. V. (2026) · Revista de Gastroenterología del Perú · doi:10.47892/rgp.2026.461.2125
Dignass, A. U., Teich, N., Kaiser, S., Sünwoldt, J., Reinhard, E., Borchert, J., & Kudernatsch, R. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2836-5222
Michalak, A., Zawada, I., Deskur, A., Kopertowska-Majchrzak, M., Talar‐Wojnarowska, R., Domżał-Magrowska, D., Eder, P., Stawczyk‐Eder, K., Waszak, K., Rydzewska, G. M., et al. (2026) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/cjgh/9955621
ÖZEN, E. N., & Hatemı, İ. (2026) · BMC Gastroenterology · doi:10.1186/s12876-026-04999-9
Topala, M., Ionescu, V., Cojocaru, M., Iacob, R. A., Gheorghe, L. S., Vădan, R., & Gheorghe, C. (2026) · Medicina · doi:10.3390/medicina62061192
Bai, X., Ihara, E., & Akiho, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40306-4.00016-8
Andersen, J. W., Troelsen, F. S., Krogh, K., Hart, A., & Dige, A. K. (2026) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2026.2698840
Yamamoto-Furusho, J. K., & Gutierrez-Herrera, F. D. (2026) · Digestion · doi:10.1159/000553638
Zhu, Z.-R., Zhao, X., Wang, C.-C., Ding, J., & He, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1857587
Napolitano, D., Bozzetti, M., Cascio, A. L., Orgiana, N., Parello, S., D’Onofrio, A. M., Autullo, G., Camardese, G., Mazza, M., Marano, G., et al. (2026) · Psychiatric Quarterly · doi:10.1007/s11126-026-10306-2
Martino, G., Merlo, E. M., Vicario, C. M., Bellone, F., Francesco, C. D., Feldt‐Rasmussen, U., Catalano, A., Fries, W., & Silvestro, O. (2026) · Research in Psychotherapy Psychopathology Process and Outcome · doi:10.4081/ripppo.2026.900
González‐Muñoza, C., Giordano, A., Gely, C., Gordillo, J., Bertoletti, F., & García-Planella, E. (2026) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2026.11928/2026
Jiang, Q., Liu, A., Liu, J., Wu, L., Zhang, Q., Xu, Q., Xie, L., Yu, Y., & Xu, Y. (2026) · Journal of Clinical Nursing · doi:10.1111/jocn.70551
Efficacy of exogenous melatonin supplements in patients with inflammatory bowel diseases
Abdelwahab, O. A., Anan, S. S., Mohamed, M. A., Seif, A. M., Elkhodary, A., & Sherif, M. E.-S. (2026) · European journal of medical research · doi:10.1186/s40001-026-05186-y
Olsen, B. C., Hagen, M., Opheim, R., Kristensen, V. A., Lund, C. I., Aabrekk, T. B., Johansen, I., Holten, K. I. A., Strande, V., Glad, I. F., et al. (2026) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izag196
Metadata
- Authors
- Knowles, S. R., Keefer, L., Wilding, H., Hewitt, C., Graff, L. A., & Mikocka-Walus, A.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Icahn School of Medicine at Mount Sinai (US)
- St Vincent's Hospital Melbourne (AU)
- University of York (GB)
- University of Manitoba (CA)
- Department of Health Sciences, University of York, York, United Kingdom
- Corresponding author
- Knowles, Simon R
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-04-23
- Volume
- 24
- Issue
- 5
- Pages
- 966-976
- ISSN
- 1078-0998 (ISSN-L)
- 1536-4844
- OpenAlex
- W2801602793
- Cited by
- 416
- References
- 146
- Citations by year
- 2026: 26 · 2025: 53 · 2024: 73 · 2023: 83 · 2022: 55 · 2021: 61 · 2020: 35 · 2019: 24 · 2018: 6
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- quality of life, inflammatory bowel disease
- MeSH terms
- Adult, Child, Colitis, Ulcerative, Crohn Disease, Humans, Quality of Life, Surveys and Questionnaires
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
