Evolution of active neurohypophysial principles among the vertebrates
Abstract
Nine active neurohypophysial peptides have been identified among the vertebrates. Arginine-vasotocin appears to be the most primitive. It occurs in cyclostomes and among representative species from all major branches of vertebrate phylogeny. The eight other neurohypophysial principles are presumed to have evolved from arginine-vasotocin after one or more reduplications of the primitive arginine-vasotocin gene. Argininevasotocin cannot be detected in the adult mammalian neurohypophysis but it has been found in the pineal and subcommissural organs of adult mammals. Arginine-vasotocin may be released into the cerebrospinal fluid and influence functions mediated by hypothalamic hypophysiotropic factors. The primitive functions of arginine-vasotocin are not clear. They may relate to cardiovascular regulation since vascular responses to arginine-vasotocin can be demonstrated in species representing all major branches of vertebrate evolution.
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The similarity in structure and the proximity of the coding regions of the OT and AVP genes suggest a gene duplication event, rather than an independent origin of the two nonapeptide lineages.
“the similarity in structure (the two neuropeptide families differ primarily at positions 3 and 8) and the presence of the coding regions of the genes in close proximity on the same chromosome both suggest a gene duplication event, rather than an independent origin of the two nonapeptide lineages”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Sawyer, 1977
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- Authors
- SAWYER, W. H.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- SAWYER, W. H.
- Venue
- American Zoologist
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-11
- Volume
- 17
- Issue
- 4
- Pages
- 727-737
- ISSN
- 0003-1569 (ISSN-L)
- OpenAlex
- W2012749082
- Cited by
- 51
- References
- 38
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 1
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Zoologist (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- neurohypophysial peptides, arginine vasotocin, gene duplication, cyclostomes, pineal gland, subcommissural organ, cerebrospinal fluid, cardiovascular regulation, vertebrate phylogeny
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