Cited by 51Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

Evolution of active neurohypophysial principles among the vertebrates

SAWYER, W. H.·1977·American Zoologist

Abstract

Nine active neurohypophysial peptides have been identified among the vertebrates. Arginine-vasotocin appears to be the most primitive. It occurs in cyclostomes and among representative species from all major branches of vertebrate phylogeny. The eight other neurohypophysial principles are presumed to have evolved from arginine-vasotocin after one or more reduplications of the primitive arginine-vasotocin gene. Argininevasotocin cannot be detected in the adult mammalian neurohypophysis but it has been found in the pineal and subcommissural organs of adult mammals. Arginine-vasotocin may be released into the cerebrospinal fluid and influence functions mediated by hypothalamic hypophysiotropic factors. The primitive functions of arginine-vasotocin are not clear. They may relate to cardiovascular regulation since vascular responses to arginine-vasotocin can be demonstrated in species representing all major branches of vertebrate evolution.

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Crossref · 10.1093/icb/17.4.727

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  • The similarity in structure and the proximity of the coding regions of the OT and AVP genes suggest a gene duplication event, rather than an independent origin of the two nonapeptide lineages.

    “the similarity in structure (the two neuropeptide families differ primarily at positions 3 and 8) and the presence of the coding regions of the genes in close proximity on the same chromosome both suggest a gene duplication event, rather than an independent origin of the two nonapeptide lineages”

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Authors
SAWYER, W. H.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
SAWYER, W. H.
Venue
American Zoologist
Published
1977-11
Volume
17
Issue
4
Pages
727-737
ISSN
0003-1569 (ISSN-L)
OpenAlex
W2012749082
Cited by
51
References
38
Citations by year
2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2016: 1
FWCI
7.90
Type
journal article
Language
en
Open access
closed
Locations
  • American Zoologist (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords
neurohypophysial peptides, arginine vasotocin, gene duplication, cyclostomes, pineal gland, subcommissural organ, cerebrospinal fluid, cardiovascular regulation, vertebrate phylogeny

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