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Cited by 836Physical Activity and HealthCardiovascular and exercise physiologyObesity, Physical Activity, Diet

The DOI matches its Crossref record; 138 of the 140 references it cites were found in a registry or an index.

Domains of physical activity and all-cause mortality: Systematic review and dose-response meta-analysis of cohort studies

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Samitz, Guenther, Egger, Matthias, Zwahlen, Marcel·2011·International Journal of Epidemiology
DOI 10.1093/ije/dyr112
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Abstract

BACKGROUND: The dose-response relation between physical activity and all-cause mortality is not well defined at present. We conducted a systematic review and meta-analysis to determine the association with all-cause mortality of different domains of physical activity and of defined increases in physical activity and energy expenditure. METHODS: MEDLINE, Embase and the Cochrane Library were searched up to September 2010 for cohort studies examining all-cause mortality across different domains and levels of physical activity in adult general populations. We estimated combined risk ratios (RRs) associated with defined increments and recommended levels, using random-effects meta-analysis and dose-response meta-regression models. RESULTS: Data from 80 studies with 1 338 143 participants (118 121 deaths) were included. Combined RRs comparing highest with lowest activity levels were 0.65 [95% confidence interval (95% CI) 0.60-0.71] for total activity, 0.74 (95% CI 0.70-0.77) for leisure activity, 0.64 (95% CI 0.55-0.75) for activities of daily living and 0.83 (95% CI 0.71-0.97) for occupational activity. RRs per 1-h increment per week were 0.91 (95% CI 0.87-0.94) for vigorous exercise and 0.96 (95% CI 0.93-0.98) for moderate-intensity activities of daily living. RRs corresponding to 150 and 300 min/week of moderate to vigorous activity were 0.86 (95% CI 0.80-0.92) and 0.74 (95% CI 0.65-0.85), respectively. Mortality reductions were more pronounced in women. CONCLUSION: Higher levels of total and domain-specific physical activity were associated with reduced all-cause mortality. Risk reduction per unit of time increase was largest for vigorous exercise. Moderate-intensity activities of daily living were to a lesser extent beneficial in reducing mortality.

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Metadata

Authors
Samitz, G., Egger, M., & Zwahlen, M.
Affiliations
  • University of Vienna (AT)
  • University of Bern (CH)
Corresponding author
Zwahlen, Marcel
ORCID
Venue
International Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2011-09-05
Volume
40
Issue
5
Pages
1382-1400
ISSN
  • 0300-5771 (ISSN-L)
  • 1464-3685
DOI
10.1093/ije/dyr112
OpenAlex
W2124173430
Cited by
836
References
140
Citations by year
2026: 30 · 2025: 27 · 2024: 29 · 2023: 47 · 2022: 62 · 2021: 68 · 2020: 71 · 2019: 59 · 2018: 74 · 2017: 94 · 2016: 76 · 2015: 81 · 2014: 47 · 2013: 46 · 2012: 22
FWCI
4.03
Type
journal article
Language
en
Open access
Locations
  • International Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion, other-oa)
  • HighWire Press Open Archive (submittedVersion)
  • Open Access CRIS of the University of Bern
Funders
Universität Wien
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
physical activity, all-cause mortality, dose-response relationship, leisure-time physical activity, activities of daily living, occupational physical activity, high-intensity exercise, moderate physical activity, energy expenditure, sex differences, recommended physical activity levels
MeSH terms
Adult, Aged, Aged, 80 and over, Cause of Death, Energy Metabolism, Female, Humans, Leisure Activities, Male, Middle Aged, Mortality, Motor Activity, Sports, Cohort Studies, Exercise, Age Distribution, Sex Distribution, Young Adult

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