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Cohort Profile: The HUNT Study, Norway
Abstract
The HUNT Study includes large total population-based cohorts from the 1980ies, covering 125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006-08). The study was primarily set up to address arterial hypertension, diabetes, screening of tuberculosis, and quality of life. However, the scope has expanded over time. In the latest survey a state of the art biobank was established, with availability of biomaterial for decades ahead. The three population based surveys now contribute to important knowledge regarding health related lifestyle, prevalence and incidence of somatic and mental illness and disease, health determinants, and associations between disease phenotypes and genotypes. Every citizen of Nord-Trøndelag County in Norway being 20 years or older, have been invited to all the surveys for adults. Participants may be linked in families and followed up longitudinally between the surveys and in several national health- and other registers covering the total population. The HUNT Study includes data from questionnaires, interviews, clinical measurements and biological samples (blood and urine). The questionnaires included questions on socioeconomic conditions, health related behaviours, symptoms, illnesses and diseases. Data from the HUNT Study are available for researchers who satisfy some basic requirements (www.ntnu.edu/hunt), whether affiliated in Norway or abroad.
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“GWAS using siblings (within-sibship GWAS) (Fig. 2) have been previously limited by available data, but are now feasible by combining well-established family studies with recent large biobanks that incidentally or by design contain thousands of sibships35–39.”
From Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects (2022) · cites this paper as [36]
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Metadata
- Authors
- Krokstad, S., Langhammer, A., Hveem, K., Holmen, T., Midthjell, K., Stene, T., Bratberg, G., Heggland, J., & Holmen, J.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Krokstad, S.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-09
- Volume
- 42
- Issue
- 4
- Pages
- 968-977
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2135255861
- Cited by
- 1,127
- References
- 41
- Citations by year
- 2026: 57 · 2025: 67 · 2024: 103 · 2023: 71 · 2022: 125 · 2021: 106 · 2020: 120 · 2019: 102 · 2018: 89 · 2017: 66 · 2016: 70 · 2015: 60 · 2014: 48 · 2013: 37 · 2012: 5
- FWCI
- 33.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Keywords
- HUNT study, population-based cohort, biobanks, hypertension, diabetes mellitus, tuberculosis screening, quality of life, health-related lifestyle, health determinants, longitudinal follow-up, family ties, health registries, socioeconomic conditions, health behavior
- MeSH terms
- Adult, Aged, Female, Health Status, Humans, Male, Middle Aged, Norway, Patient Acceptance of Health Care, Population Surveillance, Surveys and Questionnaires, Specimen Handling, Cohort Studies, Young Adult
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