A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression

Park, Lawrence T; Kadriu, Bashkim; Gould, Todd D; Zanos, Panos; Greenstein, Deanna; Evans, Jennifer W; Yuan, Peixiong; Farmer, Cristan A; Oppenheimer, Mark; George, Jomy M; Adeojo, Lilian W; Snodgrass, H Ralph; Smith, Mark A; Henter, Ioline D; Machado-Vieira, Rodrigo; Mannes, Andrew J; Zarate, Carlos A

doi:10.1093/ijnp/pyaa025

A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression

Background Ketamine has rapid-acting antidepressant effects but is associated with psychotomimetic and other adverse effects. A 7-chlorokynurenic acid is a potent and specific glycine site N-methyl-d-aspartate receptor antagonist but crosses the blood-brain barrier inefficiently. Its prodrug, L-4…