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Immunologic Response of Man to Group B Meningococcal Polysaccharide Vaccines
Abstract
Polysaccharide vaccines prepared from group B Neisseria meningitidis were tested in human volunteers. Antibody responses were tested by five different serologic assays. Titration of one vaccine (10-, 50-, 100-, and 250-µg doses) showed only one confirmed rise in antibody to the polysaccharide in 51 men tested. Another 50 volunteers who had received vaccines of different molecular sizes failed to develop significant antibody responses. Eight volunteers who received the polysaccharide of the largest molecular size showed no antibody response; three of these men also failed to respond to a booster injection. Only one individual of four who received a combined influenza virus-meningococcal group B vaccine developed significant increase in titer of antibody to meningococcal polysaccharide. Failure of the group B polysaccharide to stimulate antibody in all but a few individuals may be due to an intrinsic deficiency of the vaccines or may represent an example of immunologic tolerance.
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Cited by
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Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd Immunity
Maiden, M. C. J., Ibarz-Pavón, A. B., Urwin, R., Gray, S. J., Andrews, N. J., Clarke, S. C., Walker, A. M., Evans, M. R., Kroll, J. S., Neal, K. R., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/527401 · Cited by 442
Tappero, J. W., Lagos, R., Maldonado Ballesteros, A., Plikaytis, B., Williams, D., Dykes, J., Gheesling, L. L., Carlone, G. M., Høiby, E. A., Holst, J., et al. (1999) · JAMA · doi:10.1001/jama.281.16.1520 · Cited by 369
Lucidarme, J., Findlow, J., Chan, H., Feavers, I. M., Gray, S. J., Kaczmarski, E. B., Parkhill, J., Bai, X., Borrow, R., & Bayliss, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076932 · Cited by 21
Oftung, F., Løvik, M., Andersen, S. R., Frøholm, L. O., & Bjune, G. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01374.x · Cited by 21
Metadata
- Authors
- Wyle, F. A., Artenstein, M. S., Brandt, B. L., Tramont, E. C., Kasper, D. L., Altieri, P. L., Berman, S. L., & Lowenthal, J. P.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1972-11-01
- Volume
- 126
- Issue
- 5
- Pages
- 514-522
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2054495382
- Cited by
- 446
- References
- 0
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunologic Response of Man to Group B Meningococcal Polysaccharide Vaccines. https://app.cochat.ai/papers/10.1093/infdis/126.5.514
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- Wyle, F. A., Artenstein, M. S., Brandt, B. L., Tramont, E. C., Kasper, D. L., Altieri, P. L., Berman, S. L., & Lowenthal, J. P. (1972). Immunologic Response of Man to Group B Meningococcal Polysaccharide Vaccines. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/126.5.514
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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