The DOI matches its Crossref record.
Therapy of Cryptococcosis with a Combination of Flucytosine and Amphotericin B
Abstract
In a prospective study from May 1971 to November 1973, 20 consecutive patients with a diagnosis of disseminated cryptococcosis were treated for six weeks with a combination of amphotericin B (20 mg daily) intravenously and flucytosine (150 mg/kg daily) orally. Fifteen patients has culturally docummented Cryptococcus neoformans meningitis, and three died of infection early in therapy. Of the remaining 12 patients, eight were alive and well eight to 34 months after therapy, and four died of other causes. None of the surviving patients has relapsed. Hematologic complications developed in nine patients, three of whom had no underlying lymphoreticular disorder or therapy with known cytotoxic agents. Renal insufficiency of mild degree occurred in only six patients. A shorter period of hospitalization and reduction in toxicity of amphotericin B suggest that combined therapy is a safe and efficacious alternative to other regimens.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans
Mitchell, T. G., & Perfect, J. R. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.515 · Cited by 1,213
Vermes, A. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.2.171 · Cited by 803
ZUGER, A., LOUIE, E., HOLZMAN, R. S., SIMBERKOFF, M. S., & RAHAL, J. J. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-2-234 · Cited by 522
Groll, A. H., Piscitelli, S. C., & Walsh, T. J. (1998) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60129-5 · Cited by 377
Perfect, J. R., & Casadevall, A. (2002) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00036-3 · Cited by 363
Metadata
- Authors
- Utz, J. P., Garriques, I. L., Sande, M. A., Warner, J. F., Mandell, G. L., McGehee, R. F., Duma, R. J., & Shadomy, S.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1975-10-01
- Volume
- 132
- Issue
- 4
- Pages
- 368-373
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1995683435
- Cited by
- 170
- References
- 0
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Therapy of Cryptococcosis with a Combination of Flucytosine and Amphotericin B. https://app.cochat.ai/papers/10.1093/infdis/132.4.368
- The paper
- Utz, J. P., Garriques, I. L., Sande, M. A., Warner, J. F., Mandell, G. L., McGehee, R. F., Duma, R. J., & Shadomy, S. (1975). Therapy of Cryptococcosis with a Combination of Flucytosine and Amphotericin B. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/132.4.368
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
