Clinical pharmacology of systemic antifungal agents: A comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development

Groll, Andreas H.; Piscitelli, Stephen C.; Walsh, Thomas J.

doi:10.1016/s1054-3589(08)60129-5

Cited by 377Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

Clinical pharmacology of systemic antifungal agents: A comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development

Groll, Andreas H., Piscitelli, Stephen C., Walsh, Thomas J.·1998·Advances in pharmacology

DOI 10.1016/s1054-3589(08)60129-5

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High concentrations of amphotericin B may be harmful and cause damage to human tissues, such as the kidneys.
“Due to this toxicity, the use of amphotericin B in high concentrations may be harmful and cause damage to human tissues, such as the kidneys [26].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [26]

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Clinical Practice Guidelines for the Management Candidiasis: 2009 Update by the Infectious Diseases Society of America
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Self-citation
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Zygomycosis in a Tertiary‐Care Cancer Center in the Era of Aspergillus‐ Active Antifungal Therapy: A Case‐Control Observational Study of 27 Recent Cases
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Safety, Tolerance, and Pharmacokinetics of High-Dose Liposomal Amphotericin B (AmBisome) in Patients Infected with Aspergillus Species and Other Filamentous Fungi: Maximum Tolerated Dose Study
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Current Concepts in Antifungal Pharmacology
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ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi
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Pharmacokinetics, Excretion, and Mass Balance of Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate in Humans
Bekersky, I., Fielding, R. M., Dressler, D. E., Lee, J. W., Buell, D. N., & Walsh, T. J. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.828-833.2002 · Cited by 320 · see citing works
Pharmacology of Systemic Antifungal Agents
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Uncommon opportunistic fungi: new nosocomial threats
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Emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty‐first century
Walsh, T. J., & Groll, A. H. (1999) · Transplant Infectious Disease · doi:10.1034/j.1399-3062.1999.010404.x · Cited by 294 · see citing works
Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies
Kontoyiannis, D. P., Hachem, R. Y., Lewis, R. E., Rivero, G., Torres, H. A., Thornby, J. A., Champlin, R., Kantarjian, H. M., Bodey, G. P., & RAAD, I. I. (2003) · Cancer · doi:10.1002/cncr.11479 · Cited by 287 · see citing works
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Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens
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Preclinical Assessment of the Efficacy of Mycograb, a Human Recombinant Antibody against Fungal HSP90
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Population Pharmacokinetic Analysis of Voriconazole Plasma Concentration Data from Pediatric Studies
Karlsson, M. O., Lutsar, I., & Milligan, P. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00751-08 · Cited by 228 · see citing works
Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.
Agarwal, A. K., Rogers, P. D., Baerson, S. R., Jacob, M. R., Barker, K. S., Cleary, J. D., Walker, L. A., Nagle, D. G., & Clark, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306291200 · Cited by 204 · see citing works
Current and future antifungal therapy: new targets for antifungal agents
Andriole, V. T. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/44.2.151 · Cited by 190 · see citing works
Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives
Chaudhary, P. M., Kumar, R., Verma, A. K., Singh, D., Yadav, V., Chhillar, A. K., Sharma, G. L., & Chandra, R. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.10.032 · Cited by 187 · see citing works
Clinical hepatotoxicity associated with antifungal agents
Kyriakidis, I., Tragiannidis, A., Munchen, S., & Groll, A. H. (2016) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1270264 · Cited by 189 · see citing works
Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia
Petraitienė, R., Petraitis, V., Groll, A. H., Sein, T., Schaufele, R. L., Francesconi, A., Bacher, J., Avila, N. A., & Walsh, T. J. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.1.12-23.2002 · Cited by 182 · see citing works
Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidiasis model
Andes, D., Stamsted, T., & Conklin, R. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.922-926.2001 · Cited by 180 · see citing works
Antifungal Activity and Pharmacokinetics of Posaconazole (SCH 56592) in Treatment and Prevention of Experimental Invasive Pulmonary Aspergillosis: Correlation with Galactomannan Antigenemia
Petraitienė, R., Petraitis, V., Groll, A. H., Sein, T., Piscitelli, S. C., Candelario, M., Field‐Ridley, A., Avila, N. A., Bacher, J., & Walsh, T. J. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.857-869.2001 · Cited by 179 · see citing works
The Pharmacokinetics and Pharmacodynamics of Micafungin in Experimental HematogenousCandidaMeningoencephalitis: Implications for Echinocandin Therapy in Neonates
Hope, W. W., Mickiene, D., Petraitis, V., Petraitienė, R., Kelaher, A. M., Hughes, J. E., Cotton, M. P., Bacher, J., Keirns, J. J., Buell, D. N., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/524063 · Cited by 177 · see citing works
Advances in synthetic approach to and antifungal activity of triazoles
Shalini, K., Kumar, N., Drabu, S., & Sharma, P. K. (2011) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.7.79 · Cited by 173 · see citing works
Current challenges in the management of invasive fungal infections
Lai, C., Tan, C., Huang, Y., Shao, P., & Hsueh, P. (2008) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-007-0595-7 · Cited by 165 · see citing works
Antifungal Drug Resistance in Aspergillus
Moore, C. B., Sayers, N. M., Mosquera, J., Slaven, J. W., & Denning, D. W. (2000) · Journal of Infection · doi:10.1053/jinf.2000.0747 · Cited by 162 · see citing works
New targets and delivery systems for antifungal therapy
Walsh, T. J., Viviani, M. A., Arathoon, E., Chiou, C. C., Ghannoum, M. A., Groll, A. H., & Odds, F. C. (2000) · Medical Mycology · doi:10.1080/mmy.38.s1.335.347 · Cited by 162 · see citing works
Clinical pharmacology of antifungal compounds
Groll, A. H., Gea‐Banacloche, J., Glasmacher, A., Just‐Nübling, G., Maschmeyer, G., & Walsh, T. J. (2003) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00068-5 · Cited by 157 · see citing works
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Hoenigl, M., Arastehfar, A. A., Arendrup, M. C., Brüggemann, R. J. M., Carvalho, A., Chiller, T. M., Chen, W., Egger, M., Feys, S., Gangneux, J., et al. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00074-23 · Cited by 160 · see citing works
Ciclopirox Olamine Treatment Affects the Expression Pattern ofCandida albicansGenes Encoding Virulence Factors, Iron Metabolism Proteins, and Drug Resistance Factors
Niewerth, M., Kunze, D., Seibold, M., Schaller, M., Körting, H. C., & Hube, B. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.6.1805-1817.2003 · Cited by 145 · see citing works
The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis
Wang, H., Xu, K., Liu, L., Tan, J. P. K., Chen, Y., Li, Y., Fan, W., Wei, Z., Sheng, J., Yang, Y. Y., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.042 · Cited by 138 · see citing works
Diagnosis and therapy of Candida infections: joint recommendations of the German Speaking Mycological Society and the Paul-Ehrlich-Society for Chemotherapy
Ruhnke, M., Rickerts, V., Cornely, O. A., Buchheidt, D., Glöckner, A., Heinz, W., Höhl, R., Horré, R., Karthaus, M., Kujath, P., et al. (2011) · Mycoses · doi:10.1111/j.1439-0507.2011.02040.x · Cited by 137 · see citing works
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Groll, A. H., & Walsh, T. J. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.8.1545 · Cited by 137 · see citing works
Pharmacokinetic and Pharmacodynamic Modeling of Anidulafungin (LY303366): Reappraisal of Its Efficacy in Neutropenic Animal Models of Opportunistic Mycoses Using Optimal Plasma Sampling
Groll, A. H., Mickiene, D., Petraitienė, R., Petraitis, V., Lyman, C. A., Bacher, J., Piscitelli, S. C., & Walsh, T. J. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2845-2855.2001 · Cited by 137 · see citing works
Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B
Groll, A. H., Rijnders, B. J. A., Walsh, T. J., Adler‐Moore, J., Lewis, R. E., & Brüggemann, R. J. M. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz076 · Cited by 135 · see citing works
Antifungal activity of essential oils and their synergy with fluconazole against drug-resistant strains of Aspergillus fumigatus and Trichophyton rubrum
Khan, M. S., & Ahmad, I. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3152-3 · Cited by 127 · see citing works
Programmed cell death in pathogenic fungi
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An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans
Backer, M. D. D., Nelissen, B., Logghe, M., Viaene, J., Loonen, I., Vandoninck, S., Hoogt, R. D., Dewaele, S., Simons, F. A., Verhasselt, P., et al. (2001) · Nature Biotechnology · doi:10.1038/85677 · Cited by 124 · see citing works
The Future of Antifungal Drug Therapy: Novel Compounds and Targets
Mota Fernandes, C., Dasilva, D., Haranahalli, K., McCarthy, J. B., Mallamo, J., Ojima, I., & Del Poeta, M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01719-20 · Cited by 124 · see citing works
Safety, Pharmacokinetics, and Pharmacodynamics of Cyclodextrin Itraconazole in Pediatric Patients with Oropharyngeal Candidiasis
Groll, A. H., Wood, L., Roden, M., Mickiene, D., Chiou, C. C., Townley, E., Dad, L., Piscitelli, S. C., & Walsh, T. J. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.8.2554-2563.2002 · Cited by 123 · see citing works
The echinocandin antifungals: an overview of the pharmacology, spectrum and clinical efficacy
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Authors: Groll, A. H., Piscitelli, S. C., & Walsh, T. J.
Affiliations: National Institutes of Health (US)
ORCID: Groll, Andreas H.
Piscitelli, Stephen C.
Walsh, Thomas J.
Venue: Advances in pharmacology
Publisher: Elsevier
Published: 1998
Volume: 44
Pages: 343-500
ISSN: 1054-3589 (ISSN-L)
DOI: 10.1016/s1054-3589(08)60129-5
OpenAlex: W63281979
Cited by: 377
References: 930
Citations by year: 2026: 3 · 2025: 3 · 2024: 16 · 2023: 7 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 7 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 13 · 2014: 16 · 2013: 13 · 2012: 7
FWCI: 54.29
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advances in pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: systemic antifungal agents, clinical pharmacology, antifungal drug development, antifungal drug targets, fungal infection
MeSH terms: Animals, Antifungal Agents, Fungi, Humans, Mycoses, Triazoles

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Clinical pharmacology of systemic antifungal agents: A comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development

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