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Cited by 34Bacterial Infections and VaccinesMicrobial infections and disease researchInfluenza Virus Research Studies

Potentiation of experimental meningitis due to Haemophilus influenzae by influenza A virus.

Michaels, R. H., Myerowitz, R. L., Klaw, R.·1977·Journal of Infectious Diseases
DOI 10.1093/infdis/135.4.641
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Abstract

When Haemophilus influenzae type b was given intranasally to infant rats, a very large dose was required to produce histologic evidence of meningitis in even half of the animals tested; meningitis developed in 16 of 31 rats that received 10(7) viable bacteria at the age of five days. However, when the animals first received influenza virus, the dose of bacteria required to produce meningitis was reduced 100-fold; meningitis occurred in 10 of 21 rats given virus at two days and 10(5) viable bacteria at five days. These results suggest that prior viral infection of the upper respiratory tract may be a factor in the pathogenesis of haemophilus meningitis.

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Crossref · 10.1093/infdis/135.4.641

Cites

23 of 23 references verified0 citation errors · 0 not checkable

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  • In rats, prior influenza infection reduced the dose of H. influenzae required to cause meningitis by 100-fold, while about 50% acquired meningitis in both groups.

    “In both groups ∼50% of the rats acquired meningitis, however, the naïve rats required a 100-fold larger dose of H. influenzae (Michaels et al., 1977).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Michaels et al., 1977

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Authors
Michaels, R. H., Myerowitz, R. L., & Klaw, R.
Affiliations
University of Pittsburgh (US)
Corresponding author
Michaels, R. H.
Venue
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1977-04-01
Volume
135
Issue
4
Pages
641-645
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/135.4.641
OpenAlex
W2335060455
Cited by
34
References
23
Citations by year
2018: 1 · 2017: 1 · 2015: 1 · 2013: 1
FWCI
3.54
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Keywords
Haemophilus influenzae type b, meningitis, influenza A virus, viral-bacterial interactions, upper respiratory tract infection, infant rats, meningitis pathogenesis
MeSH terms
Animals, Haemophilus influenzae, Meningitis, Orthomyxoviridae, Rats

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