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The Capsular Polysaccharide of Bacteroides fragilis as a Virulence Factor: Comparison of the Pathogenic Potential of Encapsulated and Unencapsulated Strains
Abstract
The pathogenic potentials of encapsulated and unencapsulated strains of Bacteroides fragilis were compared by use of a rat model of intraabdominal sepsis. Implantation of encapsulated B. fragilis alone resulted in abscesses in most recipients, whereas unencapsulated strains seldom produced this effect unless they were combined with another organism. Implants of heat-killed, encapsulated B. fragilis also resulted in abscess formation. Subsequent experiments suggested that the abscess-potentiating ability of encapsulated B. fragilis is related to the capsular polysaccharide. Implantation of 200 microgram of the purified capsular material alone or in conjuction with unencapsulated strains caused abscess formation in a majority of animals. Comparable results were not obtained with capsular polysaccharide from Escherichia coli O7:K1(L)"NM or with heat-killed Streptococcus pneumoniae type III. The capsular polysaccharide of B. fragilis appears to potentiate abscess formation and may represent a virulence factor for this species.
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Cited by
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis
Sears, C. L., Geis, A. L., & Housseau, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72334 · Cited by 353
Structural Features of Polysaccharides That Induce Intra-Abdominal Abscesses
Tzianabos, A. O., Onderdonk, A. B., Rosner, B., Cisneros, R. L., & Kasper, D. L. (1993) · Science · doi:10.1126/science.8211161 · Cited by 276
Self-citationImmunochemical characterization of two surface polysaccharides of Bacteroides fragilis
Pantosti, A., Tzianabos, A. O., Onderdonk, A. B., & Kasper, D. L. (1991) · Infection and Immunity · doi:10.1128/iai.59.6.2075-2082.1991 · Cited by 110
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Metadata
- Authors
- Onderdonk, A. B., Kasper, D. L., Cisneros, R. L., & Bartlett, J. G.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-07-01
- Volume
- 136
- Issue
- 1
- Pages
- 82-89
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2033981815
- Cited by
- 322
- References
- 0
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Capsular Polysaccharide of Bacteroides fragilis as a Virulence Factor: Comparison of the Pathogenic Potential of Encapsulated and Unencapsulated Strains. https://app.cochat.ai/papers/10.1093/infdis/136.1.82
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- Onderdonk, A. B., Kasper, D. L., Cisneros, R. L., & Bartlett, J. G. (1977). The Capsular Polysaccharide of Bacteroides fragilis as a Virulence Factor: Comparison of the Pathogenic Potential of Encapsulated and Unencapsulated Strains. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/136.1.82
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