The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification and Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome
Abstract
Toxic-shock syndrome (TSS) is believed to be caused by a toxin produced by Staphylococcus aureus. An exotoxin has been identified that is associated with strains of S. aureus isolated from patients with TSS. Coded strains of S. aureus were tested for the presence of the exotoxin by polyacrylamide gel isoelectric focusing. Sixty isolates of S. aureus were tested; 28 (100%) of 28 isolates from patients with TSS but only five (16%) of 32 control isolates produced the toxin (P much less than 0.001). This protein exotoxin, which was purified by differential precipitation with ethanol and thin-layer isoelectric focusing, had an isoelectric point of 7.2. When tested by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the toxin migrated as a homogeneous protein with a molecular weight of 22,000. The exotoxin produced fever in rabbits and enhanced susceptibility to lethal shock caused by endotoxin. Other biologic properties of the exotoxin included lymphocyte mitogenicity and the capacity to suppress synthesis of IgM antibody to sheep erythrocytes.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cited by
Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P. H., & Wagner, H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.1.91 · Cited by 574
Peng, H. L., Novick, R. P., Kreiswirth, B., Kornblum, J., & Schlievert, P. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.9.4365-4372.1988 · Cited by 566
Self-citationMonecke, S., Slickers, P., & Ehricht, R. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00426.x · Cited by 293
Fast, D. J., Schlievert, P. M., & Nelson, R. D. (1989) · Infection and Immunity · doi:10.1128/iai.57.1.291-294.1989 · Cited by 272
Self-citationGlycerol monolaurate antibacterial activity in broth and biofilm cultures.
Schlievert, P. M., & Peterson, M. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040350 · Cited by 198
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Metadata
- Authors
- Schlievert, P. M., Shands, K. N., Dan, B. B., Schmid, G. P., & Nishimura, R. D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-04-01
- Volume
- 143
- Issue
- 4
- Pages
- 509-516
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2084519264
- Cited by
- 665
- References
- 1
- FWCI
- 58.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schlievert, P. M., Shands, K. N., Dan, B. B., Schmid, G. P., & Nishimura, R. D. (1981). Identification and Characterization of an Exotoxin from Staphylococcus aureus Associated with Toxic-Shock Syndrome. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/143.4.509
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
