The DOI matches its Crossref record.
Epidemiology of Clostridium difficile in Infants
Abstract
The epidemiology of Clostridium difficile was studied prospectively in 451 newborn infants by daily screening of fecal samples. Colonization rates in three postnatal wards ranged from 2% to 52%. Many colonizations were sporadic, but on two wards there was evidence of clustering. On one of these occasions prospective environmental sampling yielded C. difficile organisms from a potential common source. Mothers were shown not to be the sources of their infants' organisms. Both toxin-producing and non-toxigenic strains were common; differentiation according to toxin type was epidemiologically useful. Cross contamination is the most likely explanation of the spread of C. difficile among hospitalized infants; the organism could spread among adults who are at risk of developing antibiotic-associated colitis in a similar manner.
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Cited by
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Carey-Ann, B. D., & Carroll, K. C. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-13 · Cited by 423
Mechanisms and Management of Antibiotic‐Associated Diarrhea
Hogenauer, C., Hammer, H. F., Krejs, G. J., & Reisinger, E. C. (1998) · Clinical Infectious Diseases · doi:10.1086/514958 · Cited by 348
Johnson, S., Gerding, D. N., Olson, M. M., Weiler, M. D., Hughes, R. A., Clabots, C. R., & Peterson, L. R. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90462-m · Cited by 317
Metadata
- Authors
- Larson, H. E., Barclay, F. E., Honour, P., & Hill, I. D.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-12
- Volume
- 146
- Issue
- 6
- Pages
- 727-733
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2170738271
- Cited by
- 216
- References
- 0
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Epidemiology of Clostridium difficile in Infants. https://app.cochat.ai/papers/10.1093/infdis/146.6.727
- The paper
- Larson, H. E., Barclay, F. E., Honour, P., & Hill, I. D. (1982). Epidemiology of Clostridium difficile in Infants. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/146.6.727
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
