The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.
Diagnosis of Clostridium difficile Infection: an Ongoing Conundrum for Clinicians and for Clinical Laboratories
Open accessAbstract
SUMMARY: Clostridium difficile is a formidable nosocomial and community-acquired pathogen, causing clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to toxic megacolon and fulminant colitis. Since the early 2000s, the incidence of C. difficile disease has increased dramatically, and this is thought to be due to the emergence of new strain types. For many years, the mainstay of C. difficile disease diagnosis was enzyme immunoassays for detection of the C. difficile toxin(s), although it is now generally accepted that these assays lack sensitivity. A number of molecular assays are commercially available for the detection of C. difficile . This review covers the history and biology of C. difficile and provides an in-depth discussion of the laboratory methods used for the diagnosis of C. difficile infection (CDI). In addition, strain typing methods for C. difficile and the evolving epidemiology of colonization and infection with this organism are discussed. Finally, considerations for diagnosing C. difficile disease in special patient populations, such as children, oncology patients, transplant patients, and patients with inflammatory bowel disease, are described. As detection of C. difficile in clinical specimens does not always equate with disease, the diagnosis of C. difficile infection continues to be a challenge for both laboratories and clinicians.
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Cites
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An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile
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Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
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Cited by
McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., Dubberke, E. R., Garey, K. W., Gould, C. V., Kelly, C., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/cix1085 · Cited by 2,690
Self-citationMiller, J. M., Binnicker, M. J., Campbell, S., Carroll, K. C., Chapin, K. C., Gilligan, P. H., Gonzalez, M. D., Jerris, R. C., Kehl, S. C., Patel, R., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy381 · Cited by 641
Self-citationClostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
Cassir, N., Benamar, S., Khalil, J. B., Croce, O., Saint-Faust, M., Jacquot, A., Million, M., Azza, S., Armstrong, N., Henry, M., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ468 · Cited by 151
Dubberke, E. R., Lee, C. H., Orenstein, R., Khanna, S., Hecht, G., & Gerding, D. N. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy259 · Cited by 140
Hanson, K. E., & Couturier, M. R. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw494 · Cited by 99
Metadata
- Authors
- Carey-Ann, B. D., & Carroll, K. C.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-07
- Volume
- 26
- Issue
- 3
- Pages
- 604-630
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2148071366
- Cited by
- 423
- References
- 208
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- green
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