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High-Level Resistance to Gentamicin in Clinical Isolates of Enterococci
Abstract
Nine clinical isolates of Streptococcus faecalis from a university hospital were found to be resistant to high levels (minimal inhibitory concentration, greater than 2,000 micrograms/ml) of gentamicin, tobramycin, amikacin, streptomycin, and kanamycin. The high-level resistance to these aminoglycosides and resistance to penicillin-aminoglycoside synergism were transferable by conjugation to a susceptible recipient strain. In three strains tested, the aminoglycoside resistance was mediated by four aminoglycoside-modifying enzymes: a 3'-phosphotransferase transferred from two strains, a 2"-phosphotransferase and a 6'-acetyltransferase transferred from all three strains, and a streptomycin adenylyltransferase transferred from two strains. This is the first report of the occurrence of high-level gentamicin resistance in enterococcal isolates from the United States.
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Citations
Cited by
The life and times of the Enterococcus
Murray, B. E. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.46 · Cited by 1,908
Self-citationVancomycin-Resistant Enterococcal Infections
Murray, B. E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003093421007 · Cited by 890
Self-citationIntrinsic and acquired resistance mechanisms in enterococcus
Hollenbeck, B. L., & Rice, L. B. (2012) · Virulence · doi:10.4161/viru.21282 · Cited by 795
Management of multidrug-resistant enterococcal infections
Arias, C. A., Contreras, G. A., & Murray, B. E. (2010) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2010.03214.x · Cited by 388
Self-citationEmergence and management of drug-resistant enterococcal infections
Arias, C. A., & Murray, B. E. (2008) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.6.5.637 · Cited by 294
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Metadata
- Authors
- Mederski-Samoraj, B. D., & Murray, B. E.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-04-01
- Volume
- 147
- Issue
- 4
- Pages
- 751-757
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2079184155
- Cited by
- 213
- References
- 0
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: High-Level Resistance to Gentamicin in Clinical Isolates of Enterococci. https://app.cochat.ai/papers/10.1093/infdis/147.4.751
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- Mederski-Samoraj, B. D., & Murray, B. E. (1983). High-Level Resistance to Gentamicin in Clinical Isolates of Enterococci. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/147.4.751
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
