Cited by 796Antibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusBacterial Genetics and Biotechnology

Intrinsic and acquired resistance mechanisms in enterococcus

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Hollenbeck, Brian L., Rice, Louis B.·2012·Virulence

Abstract

Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants. This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options.

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  • AAC(6′)APH(2′′) is a bifunctional enzyme that confers high-level resistance to all aminoglycosides except streptomycin and accounts for most high-level gentamicin resistance detected in enterococci and methicillin-resistant S. aureus worldwide.

    “Furthermore, the presence of this bifunctional enzyme accounts for most of high-level gentamicin resistance detected in enterococci (including in vancomycin-resistant strains) and methicillin-resistant S. aureus worldwide (13).”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [13]

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  1. 10.1179/joc.2008.18.1.27 · DOI

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Authors
Hollenbeck, B. L., & Rice, L. B.
Affiliations
Brown University (US)
Corresponding author
Rice, Louis B.
Venue
Virulence
Published
2012-08-15
Volume
3
Issue
5
Pages
421-569
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
OpenAlex
W2084266616
Cited by
795
References
147
Citations by year
2026: 66 · 2025: 55 · 2024: 87 · 2023: 67 · 2022: 80 · 2021: 84 · 2020: 66 · 2019: 59 · 2018: 61 · 2017: 46 · 2016: 48 · 2015: 28 · 2014: 27 · 2013: 20 · 2012: 1
FWCI
1.35
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Virulence (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
Enterococcus, antibiotic resistance, intrinsic resistance, acquired resistance, Enterococcus faecium, Enterococcus faecalis, nosocomial pathogens, horizontal gene transfer, resistance determinants, antibiotic resistance mechanisms, treatment options
MeSH terms
Anti-Bacterial Agents, Cross Infection, Humans, Enterococcus faecalis, Gram-Positive Bacterial Infections, Enterococcus faecium, Drug Resistance, Bacterial

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