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Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy
Abstract
The first two confirmed cases of type E infant botulism occurred in two 16-week-old girls in Rome, Italy. The original diagnosis for the first patient was intestinal blockage due to an ileocecal invagination, which was treated surgically. Postoperatively, the patient became unresponsive and required ventilatory assistance. A diagnosis of infant botulism was then made. The second infant presented to the same hospital 7 1/2 months later with profound weakness, hypotonicity, mydriasis, and areflexia. This case was recognized as possible botulism at admission. Both cases were confirmed by detection and identification of type E botulinal toxin in stool specimens and in enrichment cultures of those specimens. The toxigenic organisms isolated were quite different from Clostridium botulinum type E. The apparent causative organism in each case resembles Clostridium butyricum but produces a neurotoxin that is indistinguishable from type E botulinal toxin by its effects on mice and by its neutralization with type E botulinal antitoxin.
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Citations
Cited by
Botulism in the United States: A Clinical and Epidemiologic Review
Shapiro, R. L., Hatheway, C., & Swerdlow, D. L. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-3-199808010-00011 · Cited by 508
Self-citationNissen, L., Zatta, A., Stefanini, I., Grandi, S., Sgorbati, B., Biavati, B., & Monti, A. (2010) · Fitoterapia · doi:10.1016/j.fitote.2009.11.010 · Cited by 295
Biology and Genomic Analysis of Clostridium botulinum
Peck, M. W. (2009) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(09)05503-9 · Cited by 275
Safety aspects of next generation probiotics
Saarela, M. H. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2018.09.001 · Cited by 118
Isa, K., Oka, K., Beauchamp, N., Sato, M., Wada, K., Ohtani, K., Nakanishi, S., McCartney, E., Tanaka, M., Shimizu, T., et al. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115607372 · Cited by 52
Metadata
- Authors
- Aureli, P., Fenicia, L., Pasolini, B., Gianfranceschi, M., McCroskey, L. M., & Hatheway, C. L.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-08-01
- Volume
- 154
- Issue
- 2
- Pages
- 207-211
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2071881166
- Cited by
- 267
- References
- 0
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy. https://app.cochat.ai/papers/10.1093/infdis/154.2.207
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- Aureli, P., Fenicia, L., Pasolini, B., Gianfranceschi, M., McCroskey, L. M., & Hatheway, C. L. (1986). Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/154.2.207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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