Safety aspects of next generation probiotics

Saarela, Maria H

doi:10.1016/j.cofs.2018.09.001

Cited by 119Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

Safety aspects of next generation probiotics

Saarela, Maria H·2019·Current Opinion in Food Science

DOI 10.1016/j.cofs.2018.09.001

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Computational tools can mitigate risks associated with NGPs by enabling whole-genome sequence analysis, early detection of antibiotic resistance genes, virulence-related traits, horizontal gene transfer potential, and negative metabolic characteristics, speeding strain selection and regulatory assessment.
“Computational tools can be applied to mitigate risks associated with NGPs by enabling whole-genome sequence analysis, early detection of antibiotic resistance genes, virulence-related traits, the potential for horizontal gene transfer, and other potentially negative metabolic characteristics, thus speeding up strain selection and regulatory assessment [140,161].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]
NGPs require greater safety consideration than traditional probiotics because they lack a safe use history and have a more ambiguous potential to cause infectious diseases.
“Another class of probiotics, NGPs (e.g., specifically commensal gut bacteria such as Bacteroides, Clostridium, and Akkermansia), require greater safety consideration than traditional probiotics because they lack a “safe use history” and have a more “ambiguous” potential to cause infectious diseases [140].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]

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Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Bacteroides : the Good, the Bad, and the Nitty-Gritty
Wexler, H. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-07 · Cited by 2,318 · see citing works
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971 · see citing works
Evidence for Extensive Resistance Gene Transfer among Bacteroides spp. and among Bacteroides and Other Genera in the Human Colon
Shoemaker, N. B., Vlamakis, H. C., Hayes, K., & Salyers, A. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.2.561-568.2001 · Cited by 529 · see citing works
Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
Hansen, C. H. F., Krych, Ł., Nielsen, D. S., Vogensen, F. K., Hansen, L. H., Sørensen, S. J., Buschard, K., & Hansen, A. K. (2012) · Diabetologia · doi:10.1007/s00125-012-2564-7 · Cited by 496 · see citing works
The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes
van Passel, M. W. J., Kant, R., Zoetendal, E. G., Plugge, C. M., Derrien, M., Malfatti, S., Chain, P., Woyke, T., Palva, A., de Vos, W. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016876 · Cited by 425 · see citing works
Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic
Martín, R., Miquel, S., Benevides, L., Bridonneau, C., Robert, V., Hudault, S., Chain, F., Berteau, O., Azevedo, V., Chatel, J. M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01226 · Cited by 398 · see citing works
Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis
Sears, C. L., Geis, A. L., & Housseau, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72334 · Cited by 354 · see citing works
A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice
Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi∥, T., Roers, A., Yagita∥, H., Ohteki, T., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.013 · Cited by 331 · see citing works
Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model
Martín, R., Miquel, S., Chain, F., Natividad, J. M., Jury, J., Lu, J., Sokol, H., Theodorou, V., Bercik, P., Verdu, E. F., et al. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0400-1 · Cited by 309 · see citing works
Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis
Qiu, X., Zhang, M., Yang, X., Hong, N., & Yu, C. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.04.002 · Cited by 287 · see citing works
The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models
Martín, R., Chain, F., Miquel, S., Lu, J., Gratadoux, J.-J., Sokol, H., Verdu, E. F., Bercik, P., Bermúdez-Humarán, L. G., & Langella, P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440815.76627.64 · Cited by 284 · see citing works
Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy
Aureli, P., Fenicia, L., Pasolini, B., Gianfranceschi, M. V., McCroskey, L. M., & Hatheway, C. L. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.2.207 · Cited by 267 · see citing works
Prevention of antibiotic‐associated diarrhea in children by Clostridium butyricum MIYAIRI
SEKI, H., SHIOHARA, M., MATSUMURA, T., MIYAGAWA, N., TANAKA, M., KOMIYAMA, A., & KURATA, S. (2003) · Pediatrics International · doi:10.1046/j.1442-200x.2003.01671.x · Cited by 253 · see citing works
Effects of probiotic, Clostridium butyricum, on growth performance, immune function, and cecal microflora in broiler chickens
Yang, C., Cao, G., Ferket, P. R., Tianshun, L. I. U., Zhou, L., Zhang, L., Xiao, Y., & Chen, A. G. (2012) · Poultry Science · doi:10.3382/ps.2011-02131 · Cited by 247 · see citing works
Functional Metabolic Map of Faecalibacterium prausnitzii, a Beneficial Human Gut Microbe
Heinken, A., Khan, M. T., Paglia, G., Rodionov, D. A., Harmsen, H. J. M., & Thiele, I. (2014) · Journal of Bacteriology · doi:10.1128/jb.01780-14 · Cited by 236 · see citing works
High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment
Dubourg, G., Lagier, J., Armougom, F., Robert, C., Audoly, G., Papazian, L., & Raoult, D. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.10.012 · Cited by 235 · see citing works
Clostridium butyricum : from beneficial to a new emerging pathogen
Cassir, N., Benamar, S., & Scola, B. L. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.014 · Cited by 234 · see citing works
Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate
Liu, J., Sun, J., Wang, F., Yu, X., Ling, Z., Li, H., Zhang, H., Jin, J., Chen, W., Pang, M., et al. (2015) · BioMed Research International · doi:10.1155/2015/412946 · Cited by 225 · see citing works
Faecalibacterium prausnitziisupernatant improves intestinal barrier function in mice DSS colitis
Carlsson, A. H., Yakymenko, O., Olivier, I., Håkansson, F., Postma, E., Keita, Å. V., & Söderholm, J. D. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.828773 · Cited by 219 · see citing works
Effects of dietary supplementation of probiotic, Clostridium butyricum, on growth performance, immune response, intestinal barrier function, and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88
Zhang, L., Zhang, L., Zhan, X., Zeng, X., Zhou, L., Cao, G., Chen, A., & Yang, C. (2016) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-016-0061-4 · Cited by 206 · see citing works
Probiotics from research to market: the possibilities, risks and challenges
Foligné, B., Daniel, C., & Pot, B. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.008 · Cited by 197 · see citing works
Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut‐brain axis
Li, H., Sun, J., Du, J., Wang, F., Fang, R., Yu, C., Xiong, J., Chen, W., Lu, Z., & Liu, J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13260 · Cited by 185 · see citing works
Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens
Mathipa-Mdakane, M. G., & Thantsha, M. S. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0178-9 · Cited by 170 · see citing works
The effect of probiotic treatment withClostridium butyricumon enterohemorrhagicEscherichia coliO157:H7 infection in mice
Takahashi, M., Taguchi, H., Yamaguchi, H., Osaki, T., Komatsu, A., & Kamiya, S. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.03.010 · Cited by 159 · see citing works
OUTBREAK OF NECROTISING ENTEROCOLITIS CAUSED BY CLOSTRIDIUM BUTYRICUM
Howard, F. M., Bradley, J., Flynn, D., Noone, P., & Szawatkowski, M. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90546-3 · Cited by 155 · see citing works
Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota
Sun, J., Wang, F., Ling, Z., Yu, X., Chen, W., Li, H., Jin, J., Pang, M., Zhang, H., Yu, J., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.042 · Cited by 147 · see citing works
Faecalibacterium prausnitzii Inhibits Interleukin-17 to Ameliorate Colorectal Colitis in Rats
Zhang, M., Qiu, X., Zhang, H., Yang, X., Hong, N., Yang, Y., Chen, H., & Yu, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109146 · Cited by 141 · see citing works
The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis
Yasueda, A., Mizushima, T., Nezu, R., Sumi, R., Tanaka, M., Nishimura, J., Kai, Y., Hirota, M., Osawa, H., Nakajima, K., et al. (2015) · Surgery Today · doi:10.1007/s00595-015-1261-9 · Cited by 141 · see citing works
Occurrence of the New Tetracycline Resistance Gene tet (W) in Bacteria from the Human Gut
Scott, K. P., Melville, C. M., Barbosa, T. M., & Flint, H. J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.775-777.2000 · Cited by 139 · see citing works
Akkermansia muciniphila: a novel functional microbe with probiotic properties
Gómez-Gallego, C., Pohl, S., Salminen, S., de Vos, W. M., & Kneifel, W. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0009 · Cited by 130 · see citing works
Antioxidants Keep the Potentially Probiotic but Highly Oxygen-Sensitive Human Gut Bacterium Faecalibacterium prausnitzii Alive at Ambient Air
Khan, M. T., van Dijl, J. M., & Harmsen, H. J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096097 · Cited by 105 · see citing works
Oral Administration of Faecalibacterium prausnitzii Decreased the Incidence of Severe Diarrhea and Related Mortality Rate and Increased Weight Gain in Preweaned Dairy Heifers
Foditsch, C., Pereira, R. V. V., Ganda, E., Gomez, M. S., Marques, E. C., Santín, T., & Bicalho, R. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145485 · Cited by 103 · see citing works
Clostridium Butyricum MIYAIRI 588 Improves High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats
Seo, M., Inoue, I., Tanaka, M., Matsuda, N., Nakano, T., Awata, T., Katayama, S., Alpers, D., & Komoda, T. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2879-3 · Cited by 95 · see citing works
Isolation and Characterization of Faecalibacterium prausnitzii from Calves and Piglets
Foditsch, C., Santos, T. M. A., Teixeira, A. G. V., Pereira, R. V. V., Dias, J. M., Gaeta, N. C., & Bicalho, R. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116465 · Cited by 95 · see citing works
Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy
Shimbo, I. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i47.7520 · Cited by 75 · see citing works
Bacteremia Due to Bacteroides fragilis Group: Distribution of Species, β-Lactamase Production, and Antimicrobial Susceptibility Patterns
Aldridge, K. E., Ashcraft, D. S., O’Brien, M., & Sanders, C. V. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.1.148-153.2003 · Cited by 71 · see citing works
A quantitative key-opinion-leader analysis of innovation barriers in probiotic research and development: Valorisation and improving the tech transfer cycle
van den Nieuwboer, M., van de Burgwal, L., & Claassen, E. (2015) · PharmaNutrition · doi:10.1016/j.phanu.2015.09.003 · Cited by 67 · see citing works
Preliminary Safety Evaluation of a New Bacteroides xylanisolvens Isolate
Ulsemer, P., Toutounian, K., Schmidt, J., Karsten, U. R., & Goletz, S. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06641-11 · Cited by 67 · see citing works
Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase
Smith, C. J., Bennett, T., & Parker, A. C. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.8.1711 · Cited by 56 · see citing works
Safety Assessment of Bacteroides uniformis CECT 7771 Isolated from Stools of Healthy Breast-Fed Infants
Fernández-Murga, M. L., & Sanz, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145503 · Cited by 55 · see citing works
Safety assessment of the Clostridium butyricum MIYAIRI 588 ® probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo
Isa, K., Oka, K., Beauchamp, N., Sato, M., Wada, K., Ohtani, K., Nakanishi, S., McCartney, E., Tanaka, M., Shimizu, T., et al. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115607372 · Cited by 52 · see citing works
Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats
Araki, Y., Andoh, A., Takizawa, J., Takizawa, W., & Fujiyama, Y. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.4.577 · Cited by 49 · see citing works
CRISPR-Cas Systems in Bacteroides fragilis, an Important Pathobiont in the Human Gut Microbiome
Tajkarimi, M. M., & Wexler, H. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02234 · Cited by 45 · see citing works
Effects of orally administered Clostridium butyricum MIYAIRI 588 on mucosal immunity in mice
Murayama, T.-I., Mita, N., Tanaka, M., Kitajo, T., Asano, T., Mizuochi, K., & Kaneko, K. (1995) · Veterinary Immunology and Immunopathology · doi:10.1016/0165-2427(95)05437-b · Cited by 44 · see citing works
Safety and tolerance of Bacteroides xylanisolvens DSM 23964 in healthy adults
Ulsemer, P., Toutounian, K., Kressel, G., Schmidt, J., Karsten, U. R., Hahn, A., & Goletz, S. (2012) · Beneficial Microbes · doi:10.3920/bm2011.0051 · Cited by 29 · see citing works
Complete Genome Sequence of Faecalibacterium prausnitzii Isolated from the Gut of a Healthy Indian Adult
Bag, S., Ghosh, T. S., & Das, B. (2017) · Genome Announcements · doi:10.1128/genomea.01286-17 · Cited by 25 · see citing works

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Manassi, C. F., de Souza, S. S., Hassemer, G. D. S., Sartor, S., Lima, C. M. G., Miotto, M., Lindner, J. D. D., Rezzadori, K., Pimentel, T. C., Ramos, G. L. D. P. A., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111035 · Cited by 66 · see citing works
Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review
Shen, X., Xie, A., Li, Z., Jiang, C., Wu, J., Li, M., & Yue, X. (2024) · Foods · doi:10.3390/foods13010151 · Cited by 63 · see citing works
Exploring the Probiotic Potential of Bacteroides spp. Within One Health Paradigm
Tufail, M. A., & Schmitz, R. A. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10370-9 · Cited by 61 · see citing works
Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study
Madempudi, R. S., Neelamraju, J., Ahire, J. J., Gupta, S. K., & Shukla, V. K. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09542-9 · Cited by 60 · see citing works
Innovation and Trends in Probiotic Microencapsulation by Emulsification Techniques
Camelo‐Silva, C., Verruck, S., Ambrosi, A., & Luccio, M. D. (2022) · Food Engineering Reviews · doi:10.1007/s12393-022-09315-1 · Cited by 56 · see citing works
Integrated genome-based probiotic relevance and safety evaluation of Lactobacillus reuteri PNW1
Alayande, K. A., Aiyegoro, O. A., Nengwekhulu, T. M., Katata‐Seru, L., & Ateba, C. N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235873 · Cited by 55 · see citing works
Personalized Nutrition Through The Gut Microbiota: Current Insights And Future Perspectives
Vandeputte, D. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa098 · Cited by 58 · see citing works
Electro-hydrodynamic processing for encapsulation of probiotics: A review on recent trends, technological development, challenges and future prospect
Niamah, A. K., Al‐Sahlany, S. T. G., Ibrahim, S. A., Verma, D. K., Thakur, M., Sıngh, S., Patel, A. R., Aguilar, C. N., & Utama, G. L. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101458 · Cited by 53 · see citing works
Probiotic Bacillus as fermentation agents: Status, potential insights, and future perspectives
Liu, S., Zhao, L., Li, M., Zhu, Y., Liang, D., Ma, Y., Sun, L., Zhao, G., & Tu, Q. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101465 · Cited by 53 · see citing works
Human Gut Microbiota for Diagnosis and Treatment of Depression
Averina, O. V., Poluektova, E. U., Zorkina, Y., Kovtun, A. S., & Даниленко, В. Н. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115782 · Cited by 53 · see citing works
Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-κB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis
Korotkyi, O., Huet, A., Dvorshchenko, K., Kobyliak, N. M., Falalyeyeva, T. M., & Остапченко, Л. І. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09735-7 · Cited by 45 · see citing works
Probiotics in human mental health and diseases—A minireview
Sivamaruthi, B. S., Prasanth, M. I., Kesika, P., & Chaiyasut, C. (2021) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i4.29 · Cited by 44 · see citing works
Recent advances in targeted manipulation of the gut microbiome by prebiotics: from taxonomic composition to metabolic function
Fan, S., Zhang, Z., Zhao, Y., Daglia, M., Zhang, J., Zhu, Y., Bai, J., Zhu, L., & Xiao, X. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100959 · Cited by 39 · see citing works
Safety assessment of Lactobacillus reuteri IDCC 3701 based on phenotypic and genomic analysis
Lee, B. S., Ban, O., Bang, W. Y., Chae, S. A., Oh, S., Park, C., Lee, M., Kim, S.-J., Yang, J., & Jung, Y. H. (2021) · Annals of Microbiology · doi:10.1186/s13213-021-01622-y · Cited by 38 · see citing works
Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota
Borgonovi, T. F., Virgolin, L. B., Janzantti, N. S., Casarotti, S. N., & Penna, A. L. B. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111809 · Cited by 38 · see citing works
Probiotic Functional Yogurt: Challenges and Opportunities
de Souza, M., Drunkler, D. A., & Colla, E. (2023) · Fermentation · doi:10.3390/fermentation10010006 · Cited by 36 · see citing works
Exploring the Multifaceted Therapeutic Potential of Probiotics: A Review of Current Insights and Applications
Chakravarty, K., Gaur, S., Kumar, R., Jha, N. K., & Gupta, P. K. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10328-x · Cited by 40 · see citing works
Understanding the Functionality of Probiotics on the Edge of Artificial Intelligence (AI) Era
Asar, R., Erenler, S., Devecioglu, D., Ispirli, H., Karbancioglu-Guler, F., Ozturk, H. I., & Dertli, E. (2025) · Fermentation · doi:10.3390/fermentation11050259 · Cited by 37 · see citing works
Effect of probiotic on serum cytokines and matrix metalloproteinases profiles during monoiodoacetate-induced osteoarthritis in rats
Korotkyi, O., Vovk, A., Галенова, Т. І., Vovk, T. B., Dvorshchenko, K., Luzza, F., Abenavoli, L., Kobyliak, N. M., Falalyeyeva, T. M., & Остапченко, Л. І. (2019) · Minerva Biotecnologica · doi:10.23736/s1120-4826.19.02548-5 · Cited by 34 · see citing works
Modulation of the intestinal microbiota and the metabolites produced by the administration of ice cream and a dietary supplement containing the same probiotics
Rodrigues, V. C. D. C., Duque, A. L. R. F., Fino, L. D. C., Simabuco, F. M., Sartoratto, A., Cabral, L., Noronha, M. F., Sivieri, K., & Antunes, A. E. C. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000896 · Cited by 33 · see citing works
Role of fructooligosaccharides in promoting beneficial gut bacteria: A Prebiotic perspective
Singh, P., Gupta, S., Kundu, A., Grover, M., & Saha, S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105726 · Cited by 32 · see citing works
Next Generation Probiotics for Neutralizing Obesogenic Effects: Taxa Culturing Searching Strategies
López‐Moreno, A., Acuña, I., Torres-Sánchez, A., Ruiz-Moreno, Á., Cerk, K., Rivas, A., Suárez, A., Monteoliva‐Sánchez, M., & Aguilera, J. (2021) · Nutrients · doi:10.3390/nu13051617 · Cited by 32 · see citing works
The Most Promising Next-Generation Probiotic Candidates—Impact on Human Health and Potential Application in Food Technology
Lalowski, P., & Zielińska, D. (2024) · Fermentation · doi:10.3390/fermentation10090444 · Cited by 30 · see citing works
The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes
Wang, C., Guo, H., Bai, J., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2024) · Food & Function · doi:10.1039/d3fo04863b · Cited by 29 · see citing works
Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
Mohr, A. E., Pugh, J., O'Sullivan, O., Black, K., Townsend, J. R., Pyne, D. B., Wardenaar, F. C., West, N. P., Whisner, C. M., & McFarland, L. V. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.809983 · Cited by 27 · see citing works
“Potential candidates are represented by microbial genera and species that have not been used in the food industry (27).”
Background
Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools
Murgiano, M., Bartocci, B., Puca, P., Vincenzo, F. D., GAUDIO, A. D., Papa, A., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Lopetuso, L. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073059 · Cited by 30 · see citing works
Combined effects of probiotic and chondroprotector during osteoarthritis in rats
Korotkyi, O., Dvorshchenko, K., Falalyeyeva, T. M., Sulaieva, O., Kobyliak, N. M., Abenavoli, L., Fagoonee, S., Pellicano, R., & Остапченко, Л. І. (2020) · Panminerva Medica · doi:10.23736/s0031-0808.20.03841-0 · Cited by 26 · see citing works
Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin
Filardi, R., Gargari, G., Mora, D., & Arioli, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-23980-6 · Cited by 26 · see citing works
The Use of Probiotic Therapy in Metabolic and Neurological Diseases
Lee, S. H. F., Ahmad, S. R., Lim, Y. C., & Zulkipli, I. N. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.887019 · Cited by 25 · see citing works
Emerging trends and applications in health-boosting microorganisms-specific strains for enhancing animal health
Fu, C. M., Shah, A. A., Khan, R. U., Khan, M. S., & Wanapat, M. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106290 · Cited by 25 · see citing works
Niche-Specific Adaptive Evolution of Lactobacillus plantarum Strains Isolated From Human Feces and Paocai
Pan, Q., Cen, S., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.615876 · Cited by 24 · see citing works
Probiotic consumption influences universal adaptive mutations in indigenous human and mouse gut microbiota
Ma, C., Zhang, C., Chen, D., Jiang, S., Shen, S., Huo, D., Huang, S. W., Zhai, Q., & Zhang, J. (2021) · Communications Biology · doi:10.1038/s42003-021-02724-8 · Cited by 24 · see citing works
Role of nanomaterials in improving the functionality of probiotics; integration of nanotechnology onto micro-structured platforms
Sadeghi, A., Ebrahimi, M. T., Kharazmi, M. S., & Jafari, S. M. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102843 · Cited by 24 · see citing works
Current Concepts in Probiotic Safety and Efficacy
Churin, A. A., Sokolyanskaya, L. O., Lukina, A. P., & Karnachuk, O. V. (2026) · Nutrients · doi:10.3390/nu18040696 · Cited by 31 · see citing works
“…of probiotics, NGPs (e.g., specifically commensal gut bacteria such as Bacteroides , Clostridium , and Akkermansia ), require greater safety consideration than traditional probiotics because they lack a “safe use history” and have a more “ambiguous” potential to cause infectious diseases [140].”
A Review of Next-Generation Probiotics—As a Gateway to Biotherapeutics
Vijayaganapathi, A., & Mohanasrinivasan, V. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10606-2 · Cited by 25 · see citing works
Functional Microbes and Their Incorporation into Foods and Food Supplements: Probiotics and Postbiotics
Puntillo, M. A., Segli, F., Champagne, C. P., Raymond, Y., & Vinderola, G. (2022) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-052720-011545 · Cited by 22 · see citing works
Microbiota analysis for risk assessment: evaluation of hazardous dietary substances and its potential role on the gut microbiome variability and dysbiosis
Cerk, K., & Aguilera, J. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.e200404 · Cited by 21 · see citing works
The impact of novel probiotics isolated from the human gut on the gut microbiota and health
Caesar, R. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16129 · Cited by 20 · see citing works
Cellulose Pulp- and Castor Oil-Based Polyurethanes for Lubricating Applications: Influence of Streptomyces Action on Barley and Wheat Straws
Borrero‐López, A. M., Valencia, C., Blánquez, A., Hernández, M., Eugenio, M. E., & Franco, J. M. (2020) · Polymers · doi:10.3390/polym12122822 · Cited by 20 · see citing works
Isolation and identification of a human intestinal bacterium capable of daidzein conversion
Guo, Y., Zhao, L., Fang, X., Zhong, Q., Liang, H., Liang, W., & Wang, L. (2021) · FEMS Microbiology Letters · doi:10.1093/femsle/fnab046 · Cited by 19 · see citing works
Next-Generation Probiotics - The Future of Biotherapeutics
(2022) · Microbial Bioactives · doi:10.25163/microbbioacts.514309 · Cited by 18 · see citing works
In vitro evaluation of potential prebiotic effects of a freeze-dried juice from Pilosocereus gounellei (A. Weber ex K. Schum. Bly. Ex Rowl) cladodes, an unconventional edible plant from Caatinga biome
Ribeiro, T. S., Sampaio, K. B., Menezes, F. N. D. D., de Assis, P. O. A., Lima, M. D. S., de Oliveira, M. E. G., de Souza, E. L., & Queiroga, R. D. C. R. D. E. (2020) · 3 Biotech · doi:10.1007/s13205-020-02442-8 · Cited by 18 · see citing works
Effects of Clostridium butyricum as an Antibiotic Alternative on Growth Performance, Intestinal Morphology, Serum Biochemical Response, and Immunity of Broilers
Yang, T., Du, M., Zhang, J., Ahmad, B., Cheng, Q., Wang, X., Abbas, Z., Tong, Y., Li, J., Zhou, Y., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12030433 · Cited by 17 · see citing works
Exploring Next Generation Probiotics for Metabolic and Microbiota Dysbiosis Linked to Xenobiotic Exposure: Holistic Approach
Torres-Sánchez, A., Ruiz-Rodriguez, A., Ortíz, P., Moreno, M. A., Ampatzoglou, A., Gruszecka‐Kosowska, A., Monteoliva‐Sánchez, M., & Aguilera, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112917 · Cited by 17 · see citing works
Research trends of next generation probiotics
Hasnain, M. A., Kang, D., & Moon, G. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01626-9 · Cited by 17 · see citing works
Scanning Electron Microscopy (SEM) as an Effective Tool for Determining the Morphology and Mechanism of Action of Functional Ingredients
Bede, D., & Lou, Z. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1939368 · Cited by 14 · see citing works
Next-generation probiotics
Barbosa, J. C., Machado, D., Almeida, D., Andrade, J. C., Brandelli, A., Gomes, A., & Freitas, A. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85170-1.00012-9 · Cited by 13 · see citing works
Tailoring gut microbiota with a combination of Vitamin K and probiotics as a possible adjuvant in the treatment of rheumatic arthritis: a systematic review
Pereira, L. J. R., & Monteiro, R. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.08.002 · Cited by 13 · see citing works
Probiotics in fermented products and supplements
Baliyan, N., Kumari, M., Kumari, P., Dindhoria, K., Mukhia, S., Kumar, S., Gupta, M., & Kumar, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823506-5.00014-x · Cited by 12 · see citing works
Microbiological quality of probiotic products
Zavišić, G., Ristić, S., Petković, B., Živkov-Šaponja, D., Jojić, N., & Janković, D. (2023) · Arhiv za farmaciju · doi:10.5937/arhfarm73-42160 · Cited by 9 · see citing works
Trends and challenges for the application of probiotic lactic acid bacteria in functional foods
Silva, A. S., Casarotti, S. N., & Penna, A. L. B. (2023) · Ciência Rural · doi:10.1590/0103-8478cr20230014 · Cited by 8 · see citing works
Overall Safety Considerations and Regulatory Oversight for Probiotics‐based Foods and Beverages
Koirala, S., Thapa, S. P., & Anal, A. K. (2022) · doi:10.1002/9781119702160.ch18 · Cited by 8 · see citing works
Conventional versus emerging techniques in probiotic enumeration: a comprehensive review
Sun, X., Zhang, J., Chen, J., Yang, L., Pang, X., Fan, Y., Chen, X., Chen, K., Liu, C., Li, X., et al. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2527355 · Cited by 6 · see citing works
Next-Generation Probiotics Their Molecular Taxonomy and Health Benefits
Khan, S. T., & Malik, A. R. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-24903-8_16 · Cited by 7 · see citing works
Probiotics, Microbiome and the Concept of Cross-Feeding
Torres-Miranda, A., Vega, M. A., & Garrido, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00055-3 · Cited by 7 · see citing works
A next generation probiotic, Bacteroides xylanisolvens
Chen, C., Nie, Q., Lin, Q., Zou, J., & Nie, S. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105173 · Cited by 5 · see citing works
Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security
Yaekob, A. T., Gebreslassie, G., Mesele, E., & Semere, T. (2026) · Food Bioengineering · doi:10.1002/fbe2.70046 · Cited by 5 · see citing works
Introduction to Probiotics and Their Potential Health Benefits
El-Dalatony, M. M., & Li, X. (2020) · Springer eBooks · doi:10.1007/978-981-15-4759-1_3 · Cited by 5 · see citing works
Next-Generation Probiotics
Kumari, M., & Kokkiligadda, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822909-5.00004-6 · Cited by 5 · see citing works
Probiotic innovation: From next-generation strains and advanced encapsulation strategies to probiotic engineering
Allahverdi, M., & Dadmehr, M. (2026) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2026.108917 · Cited by 4 · see citing works
Exploring Enterococcus Species for their Next-Generation Probiotics Potential
Hussain, A., & Ali, S. A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007306 · Cited by 4 · see citing works
Therapeutic potential of wavelength-dependent photobiomodulation on gut inflammation in an in vitro intestinal model
Kang, M., Jo, J., Shin, H., & Kang, H. W. (2025) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2025.113201 · Cited by 3 · see citing works
Exploring compositional and predicted functional alterations of gut microbiota in H. pylori infection
Soliman, N. S., Soliman, M. S., Aziz, H. S. A., & El‐Kholy, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-22788-4 · Cited by 3 · see citing works
Extracellular Vesicles of Probiotics: From Structural and Functional Characteristics to Practical Application
Chernov, V. M., Chernova, O. A., Markelova, M., & Trushin, M. V. (2024) · Nanobiotechnology Reports · doi:10.1134/s2635167624600792 · Cited by 3 · see citing works
Insights on the modulatory role of Ayurveda-based herbal preparations on gut microbiome and neuroprotection
Rajini, P. S., Bharath, M. M. S., & Muralidhara, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00020-4 · Cited by 4 · see citing works
Milk and dairy product intakes, intestinal bacteria, and respiratory infections in children of elementary school age and older in Japan
Yamakawa, M., Wada, K., Hayashi, M., Ezaki, T., Nakashima, Y., Nagata, C., & Sumoto, Y. (2023) · Nutrition · doi:10.1016/j.nut.2023.112145 · Cited by 3 · see citing works
Scientific and Pharmaceutical Aspects of Christensenella minuta, a Promising Next-Generation Probiotic
Pető, Á., Kósa, D., Szilvássy, Z., Fehér, P. S., Ujhelyi, Z., Kovács, G. E., Német, I., Pócsi, I., & Bácskay, I. (2023) · Fermentation · doi:10.3390/fermentation9080767 · Cited by 3 · see citing works
Prebiotics and Probiotics Food
Sankarganesh, P., Adeyeye, S. A. O., Chakka, A. K., & Babu, A. S. (2024) · doi:10.1002/9781394237623.ch16 · Cited by 3 · see citing works
Probiotics in the treatment of acute intestinal infections in children (Review of scientific publications)
Lobzin, Y., Gorelov, A. V., Gritsenko, V. A., Migacheva, N., Usenko, D., & Ermolenko, K. (2025) · Journal Infectology · doi:10.22625/2072-6732-2025-17-1-5-14 · Cited by 2 · see citing works
Kombucha-derived acetic acid bacteria and yeasts as transient functional microbes: Functional potential, evidence gaps, and future perspectives
Koh, E. J. X., Lim, S. J., Hu, W. S. L., & Sofian‐Seng, N. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109233 · Cited by 2 · see citing works
Current Status and Prospects for Standards, Regulations, and Detection of Probiotic Yogurt: Review
Chon, J., Seo, K., Kim, T.-J., Youn, H., Kang, S.-H., Hwang, W.-U., Jeong, H., Jeong, D., & Song, K. (2023) · Journal of Dairy Science and Biotechnology · doi:10.22424/jdsb.2023.41.1.9 · Cited by 2 · see citing works
Studies on the Probiotic, Adhesion, and Induction Properties of Artisanal Lactic Acid Bacteria: to Customize a Gastrointestinal Niche to Trigger Anti-obesity Functions
KAMBER, A., Albayrak, Ç. B., & Harsa, Ş. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10357-6 · Cited by 2 · see citing works
REMOVED: Biotechnological approaches in fish gut microbiome
Prakash, K., Vijayan, M., Venkatesan, B., Annamalai, K. K., Manigundan, K., Radhakrishnan, M., & Gopikrishnan, V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22348-8.00022-2 · Cited by 2 · see citing works
International Symposium on Ruminant Physiology: The holobiont concept in ruminant physiology—More of the same, or something new and meaningful to food quality, food security, and animal health?
Callaway, T. R., Perez, H. G., Corcionivoschi, N., Bu, D., & Fluharty, F. L. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25847 · Cited by 2 · see citing works
Integrative multiomics: Understanding postbiotics and their role in human physiology
Barathikannan, K., Chelliah, R., David, H. A., Kulandairaj, E. P., Vijayalakshmi, S., Rubab, M., & Oh, D.-H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22188-0.00021-8 · Cited by 2 · see citing works

Next generation probiotics for human health: An emerging perspective
Jan, T., Negi, R., Sharma, B., Kumar, S., Singh, S., Rai, A. K., Shreaz, S., Rustagi, S., Chaudhary, N., Kaur, T., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35980 · Cited by 95 · see citing works
Investiture of next generation probiotics on amelioration of diseases – Strains do matter
Lin, T., Shu, C.-C., Lai, W.-F., Tzeng, C., Lai, H., & Lu, C. (2019) · Medicine in Microecology · doi:10.1016/j.medmic.2019.100002 · Cited by 93 · see citing works
Next-generation probiotics: beyond lactic acid bacteria to untapped taxa and engineered strains for better health
Uribe, R. V., Sankaran, S., Bermúdez‐Humarán, L. G., van Pijkeren, J. P., Motherway, M. O., Ross, P., Hill, C., & Lebeer, S. (2026) · Current Opinion in Microbiology · doi:10.1016/j.mib.2026.102846
New-Generation Probiotics
Dahiya, D. K., Renuka, Dangi, A. K., Shandilya, U. K., Puniya, A. K., & Shukla, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815249-2.00044-0 · Cited by 17 · see citing works
Next-generation probiotics: Innovations in safety assessments
Hua, Z., Liu, S., Yang, G., Hou, X., & Fang, Y. (2025) · Current Opinion in Food Science · doi:10.1016/j.cofs.2024.101238 · Cited by 29 · see citing works

Authors: Saarela, M. H.
Affiliations: VTT Technical Research Centre of Finland (FI)
Corresponding author: Saarela, Maria H
ORCID: Saarela, Maria H
Venue: Current Opinion in Food Science
Publisher: Elsevier BV
Published: 2019-12
Volume: 30
Pages: 8-13
ISSN: 2214-7993 (ISSN-L)
DOI: 10.1016/j.cofs.2018.09.001
OpenAlex: W2889616411
Cited by: 118
References: 51
Citations by year: 2026: 10 · 2025: 13 · 2024: 18 · 2023: 18 · 2022: 22 · 2021: 19 · 2020: 11 · 2019: 7
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Food Science (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: next-generation probiotics, probiotic safety assessment, gut microbiota, Bacteroides, Clostridium, Faecalibacterium, Akkermansia, antibiotic resistance genes, probiotic supplements, health-promoting properties

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Safety aspects of next generation probiotics

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