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Cited by 276Antibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyAntimicrobial Resistance in Staphylococcus

Emergence of Resistance to Imipenem During Therapy for Pseudomonas aeruginosa Infections

Quinn, J. P., Dudek, E. J., DiVincenzo, C. A., Lucks, D. A., Lerner, S. A.·1986·Journal of Infectious Diseases
DOI 10.1093/infdis/154.2.289
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Abstract

We studied the mechanism of resistance to imipenem in three clinical isolates of Pseudomonas aeruginosa. Two of these isolates arose from imipenem-susceptible strains isolated during therapy with imipenem and were associated with treatment failure. One of these two strains had previously been broadly resistant to beta-lactams; the second acquired resistance to imipenem alone. One isolate of the third strain was resistant to imipenem but susceptible to other antipseudomonal beta-lactams. No isolate contained beta-lactamase activity capable of hydrolyzing imipenem at a detectable rate. Studies of the penicillin-binding proteins of all isolates revealed no differences in the number of proteins, molecular weight of, affinity for penicillin, or affinity for imipenem in any isolate. In each case the resistant isolate lacked one or more outer membrane proteins that were present in a susceptible isolate of the same strain. The observed alterations in outer membrane proteins may be associated with diminished permeability of the bacterial outer membrane to imipenem and may be the major factor responsible for resistance in these isolates.

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Crossref · 10.1093/infdis/154.2.289

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  • Aberrant production of OprD in P. aeruginosa is a classic example of porin-mediated resistance.

    “One classic example of porin-mediated resistance is the aberrant production of OprD in P. aeruginosa”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [40]

  • Mutations in the oprD gene arise in clinical isolates of P. aeruginosa during therapy.

    “Mutations in the oprD gene have been shown to arise in clinical isolates of P. aeruginosa during therapy (40).”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [40]

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Authors
Quinn, J. P., Dudek, E. J., DiVincenzo, C. A., Lucks, D. A., & Lerner, S. A.
Affiliations
Loyola University Medical Center (US)
Corresponding author
Quinn, J. P.
ORCID
Quinn, J. P.
Venue
Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
1986-08-01
Volume
154
Issue
2
Pages
289-294
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1093/infdis/154.2.289
OpenAlex
W2320473396
Cited by
276
References
29
Citations by year
2026: 2 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 2
FWCI
10.92
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI07099)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
imipenem resistance, Pseudomonas aeruginosa, acquired antibiotic resistance, outer membrane proteins, outer membrane permeability, penicillin-binding proteins, beta-lactam resistance, treatment failure, beta-lactamase
MeSH terms
Adult, Aminoglycosides, Anti-Bacterial Agents, Bacterial Outer Membrane Proteins, Bacterial Proteins, beta-Lactamases, Muramoylpentapeptide Carboxypeptidase, Carrier Proteins, Female, Hexosyltransferases, Humans, Male, Middle Aged, Penicillin Resistance, Penicillins, Peptidyl Transferases, Pseudomonas aeruginosa, Pseudomonas Infections, Thienamycins, Imipenem, Penicillin-Binding Proteins

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