The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock
Open accessAbstract
Serum concentrations of immunoreactive tumor necrosis factor/cachectin (TNF), interleukin-1 beta (IL-1 beta), interferon-gamma (IFN gamma), and interferon-alpha (IFN alpha) were prospectively measured in 70 patients with septic shock to determine their evolution and prognostic values. In a univariate analysis, levels of TNF (P = .002) and IL-1 beta (P = .05) were associated with the patient's outcome, but not IFN alpha (P = .15) and IFN gamma (P = .26). In contrast, in a stepwise logistic regression analysis, the severity of the underlying disease (P = .01), the age of the patient (P = .02), the documentation of infection (nonbacteremic infections vs. bacteremias, P = .03), the urine output (P = .04), and the arterial pH (P = .05) contributed more significantly to prediction of patient outcome than the serum levels of TNF (P = .07). After 10 days, the median concentration of TNF was undetectable (less than 100 pg/ml) in the survivors, whereas it remained elevated (305 pg/ml, P = .002) in the nonsurvivors. Thus, in patients with septic shock due to various gram-negative bacteria, other parameters than the absolute serum concentration of immunoreactive TNF contributed significantly to the prediction of outcome.
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Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 3×
“Tumor necrosis factor/cachectin (TNF) is a cytokine produced by activated macrophages [1] shown in experimental studies to be a primary mediator of the deleterious effects of endotoxin [2-10].”
BackgroundDetection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677 · cited 4×
“levels in volunteers were undetectable 4 h after a single injection of endotoxin [8], 79 96 of our patients had detectable levels of TNF 10 h after the development of shock, probably r flecting differences of infectious stimuli between volunteers and patients.”
BackgroundInfluential
Cited by
Pierrakos, C., & Vincent, J.-L. (2010) · Critical Care · doi:10.1186/cc8872 · Cited by 1,377
Bone, R. C. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-457 · Cited by 1,368
Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
Fisher, C. J., Agosti, J. M., Opal, S. M., Lowry, S. F., Balk, R. A., Sadoff, J. C., Abraham, E., Schein, R. M. H., & Benjamin, E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606273342603 · Cited by 1,241
Annane, D. (2000) · JAMA · doi:10.1001/jama.283.8.1038 · Cited by 1,000
Bakker, J., Gris, P., Coffernils, M., Kahn, R. J., & Vincent, J.-L. (1996) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)89552-9 · Cited by 851
Metadata
- Authors
- Calandra, T., Baumgartner, J.-D., Grau, G. E., Wu, M.-M., Lambert, P.-H., Schellekens, J., Verhoef, J., Glauser, M. P., & Swiss-Dutch J5 Immunoglobulin Study Group
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-05-01
- Volume
- 161
- Issue
- 5
- Pages
- 982-987
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2321427723
- Cited by
- 547
- References
- 3
- FWCI
- 35.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock. https://app.cochat.ai/papers/10.1093/infdis/161.5.982
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- Calandra, T., Baumgartner, J.-D., Grau, G. E., Wu, M.-M., Lambert, P.-H., Schellekens, J., Verhoef, J., Glauser, M. P., & Swiss-Dutch J5 Immunoglobulin Study Group. (1990). Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/161.5.982
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
