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Fucosylated Oligosaccharides of Human Milk Protect Suckling Mice from Heat-Stabile Enterotoxin of Escherichia coli
Abstract
Human milk protects suckling mice from the diarrheagenic effects of heat-stabile enterotoxin of Escherichia coli (ST). To identify the human milk fraction responsible for this protection, pooled skimmed, deproteinated milk was passed through charcoal, whereupon lactose was separated from the oligosaccharides. The oligosaccharides contained ST-protective activity; the lactose did not. The neutral, but not the acidic, fraction exhibited protective activity against ST (22% vs. 57% mortality, respectively; P less than .001). The fucosylated, but not the nonfucosylated, subfractions of the neutral fraction contained the factor protective against ST (35% vs. 50% mortality, respectively; P less than .05). An oligosaccharide isolation scheme based on different principles produced confirmatory results. The commercially available neutral fucosylated oligosaccharides of human milk did not significantly protect the mice from the effects of ST. Thus, the protective factor against ST seems to be a minor neutral fucosyloligosaccharide of human milk.
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Citations
Cited by
Ruiz-Palacios, G. M., Cervantes, L. E., Ramos, P., Chavez-Munguia, B., & Newburg, D. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207744200 · Cited by 608
Self-citationA Strategy for Annotating the Human Milk Glycome
Ninonuevo, M. R., Park, Y., Yin, H., Zhang, J., Ward, R. E., Clowers, B. H., German, J. B., Freeman, S. L., Killeen, K., Grimm, R., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0615810 · Cited by 494
Thomas, S., Izard, J., Walsh, E., Batich, K., Chongsathidkiet, P., Clarke, G., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 367
Breastfeeding Provides Passive and Likely Long-Lasting Active Immunity
Hanson, L. A. (1998) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)62704-4 · Cited by 339
Early life: gut microbiota and immune development in infancy
Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0027 · Cited by 338
Metadata
- Authors
- Newburg, D. S., Pickering, L. K., McCluer, R. H., & Cleary, T. G.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11-01
- Volume
- 162
- Issue
- 5
- Pages
- 1075-1080
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2100962201
- Cited by
- 163
- References
- 0
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fucosylated Oligosaccharides of Human Milk Protect Suckling Mice from Heat-Stabile Enterotoxin of Escherichia coli. https://app.cochat.ai/papers/10.1093/infdis/162.5.1075
- The paper
- Newburg, D. S., Pickering, L. K., McCluer, R. H., & Cleary, T. G. (1990). Fucosylated Oligosaccharides of Human Milk Protect Suckling Mice from Heat-Stabile Enterotoxin of Escherichia coli. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/162.5.1075
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