Early life: gut microbiota and immune development in infancy
Abstract
The immune system of infants is actively downregulated during pregnancy and therefore the first months of life represent a period of heightened susceptibility to infection. After birth, there is an age-dependent maturation of the immune system. Exposure to environmental microbial components is suggested to play an important role in the maturation process. The gastrointestinal tract is the major site of interaction between the host immune system and microorganisms, both commensal as well as potentially pathogenic. It is well established that the mammalian immune system is designed to help protect the host from invading microorganisms and other danger signals. However, recent research is emerging in the field of host-microbe interactions showing that commensal microorganisms (microbiota) are most likely one of the drivers of immune development and, in turn the immune system shapes the composition of the microbiota. Specific early microbial exposure of the gut is thought to dramatically reduce the incidence of inflammatory, autoimmune and atopic diseases further fuelling the scientific view that microbial colonisation plays an important role in regulating and fine-tuning the immune system throughout life. Therefore, the use of pre-, pro- and synbiotics may result in a beneficial microbiota composition that might have a pivotal role on the prevention of several important diseases that develop in early life such as necrotizing enterocolitis and atopic eczema.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The intestinal microbiota regulates important metabolic and physiological functions of the host and drives the maturation of the immune system in early life, contributing to homeostasis during life.
“This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life.”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [14]
Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202 · see citing works
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Worlds within worlds: evolution of the vertebrate gut microbiota
Ley, R. E., Lozupone, C., Hamady, M., Knight, R. D., & Gordon, J. I. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1978 · Cited by 1,652 · see citing works
Allergy, Parasites, and the Hygiene Hypothesis
Yazdanbakhsh, M., Kremsner, P. G., & van Ree, R. (2002) · Science · doi:10.1126/science.296.5567.490 · Cited by 1,527 · see citing works
Immune adaptations that maintain homeostasis with the intestinal microbiota
Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works
Anatomical basis of tolerance and immunity to intestinal antigens
Mowat, A. M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1057 · Cited by 1,414 · see citing works
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255 · see citing works
Innate immunity of the newborn: basic mechanisms and clinical correlates
Levy, O. (2007) · Nature reviews. Immunology · doi:10.1038/nri2075 · Cited by 1,227 · see citing works
Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians
Moore, W. E. C., & Holdeman, L. V. (1974) · Applied Microbiology · doi:10.1128/am.27.5.961-979.1974 · Cited by 1,144 · see citing works
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096 · see citing works
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202604299 · Cited by 1,095 · see citing works
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2297 · Cited by 1,062 · see citing works
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012 · see citing works
Is meconium from healthy newborns actually sterile?
Jiménez, E., Marín, M. L., Martı́n, R., Odriozola, J. M., Olivares, M. M., Xaus, J., Fernández, L., & Rodríguez, J. M. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2007.12.007 · Cited by 944 · see citing works
Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut
COLLINS, M. D., & Gibson, G. R. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1052s · Cited by 899 · see citing works
Grölund, M., Lehtonen, O. ‐., Eerola, E., & Kero, P. O. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199901000-00007 · Cited by 873 · see citing works
Xu, J., & Gordon, J. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734063100 · Cited by 856 · see citing works
Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. (2000) · Science · doi:10.1126/science.289.5484.1560 · Cited by 843 · see citing works
Sanos, S. L., Bui, V. L., Mortha, A., Oberle, K., Heners, C., Johner, C., & Diefenbach, A. (2008) · Nature Immunology · doi:10.1038/ni.1684 · Cited by 843 · see citing works
Influences of microbiota on intestinal immune system development.
Cebra, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1046s · Cited by 819 · see citing works
Human milk is a source of lactic acid bacteria for the infant gut
Martín, R., Langa, S., Reviriego, C., Jimínez, E., Marín, M. L., Xaus, J., Fernández, L., & Rodríguez, J. M. (2003) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.09.028 · Cited by 792 · see citing works
Homeostasis and Inflammation in the Intestine
Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 784 · see citing works
He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748 · see citing works
Kukkonen, A. K., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., & Kuitunen, M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.009 · Cited by 708 · see citing works
Bacterial Imprinting of the Neonatal Immune System: Lessons From Maternal Cells?
Pérez, P. F., Dore, J. M., Leclerc, M., Levenez, F., Benyacoub, J., Serrant, P., Segura-Roggero, I., Schiffrin, E. J., & Donnet‐Hughes, A. (2007) · PEDIATRICS · doi:10.1542/peds.2006-1649 · Cited by 676 · see citing works
Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676 · see citing works
Moro, G. E. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.098251 · Cited by 633 · see citing works
Collaboration of epithelial cells with organized mucosal lymphoid tissues
Neutra, M. R., Mantis, N. J., & Kraehenbühl, J.-P. (2001) · Nature Immunology · doi:10.1038/ni1101-1004 · Cited by 580 · see citing works
microRNA as a new immune-regulatory agent in breast milk
Kosaka, N., Izumi, H., Sekine, K., & Ochiya, T. (2010) · Silence · doi:10.1186/1758-907x-1-7 · Cited by 563 · see citing works
Diversity of the human gastrointestinal tract microbiota revisited
Rajilić‐Stojanović, M., Smidt, H., & De Vos, W. M. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01369.x · Cited by 559 · see citing works
Epithelial M Cells: Gateways for Mucosal Infection and Immunization
Neutra, M. R., Frey, A., & Kraehenbühl, J.-P. (1996) · Cell · doi:10.1016/s0092-8674(00)80106-3 · Cited by 549 · see citing works
Bacterial contributions to mammalian gut development
Hooper, L. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.01.001 · Cited by 541 · cited 2× · see citing works
“Comparisons of germ-free and conventional colonised mice have revealed that Paneth cells participate in at least two bacterial-induced developmental transitions: the postnatal expansion of the gut epithelial antimicrobial arsenal and the development of a robust villus capillary network (Hooper, 2004).”
BackgroundWillemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Breast Milk as the Gold Standard for Protective Nutrients
Walker, A. W. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.021 · Cited by 517 · see citing works
Arslanoğlu, S., Moro, G. E., Schmitt, J., Tandoi, L., Rizzardi, S., & Boehm, G. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1091 · Cited by 515 · see citing works
Moro, G. E., MINOLI, I., Mosca, M., Fanaro, S., Jelínek, J., Stahl, B., & Boehm, G. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200203000-00014 · Cited by 509 · see citing works
Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
Heikkilä, M., & Saris, P. E. J. (2003) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2003.02002.x · Cited by 501 · see citing works
Hall, J. A., Bouladoux, N. J., Sun, C., Wohlfert, E. A., Blank, R. B., Zhu, Q., Grigg, M. E., Berzofsky, J. A., & Belkaid, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.009 · Cited by 490 · see citing works
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482 · see citing works
Cesarean Delivery May Affect the Early Biodiversity of Intestinal Bacteria1,
Biasucci, G., Benenati, B., Morelli, L., Bessi, E., & Boehm, G. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.9.1796s · Cited by 458 · see citing works
Martı́n, R., Jiménez, E., Heilig, H. G. H. J., Fernández, L., Marín, M. L., Zoetendal, E. G., & Rodríguez, J. M. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02063-08 · Cited by 434 · see citing works
Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423 · see citing works
Knol, J., Scholtens, P. A. M. J., Kafka, C., Steenbakkers, J., Gro, S., Helm, K., Klarczyk, M., pfer, H. S., ckler, H.-M. B., & Wells, J. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200501000-00007 · Cited by 422 · see citing works
Self-citationKuitunen, M., Kukkonen, A. K., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., Haahtela, T., & Savilahti, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.019 · Cited by 408 · see citing works
Marchant, A., Goetghebuer, T., Ota, M. O. C., Wolfe, I., Ceesay, S. J., Groote, D. D., Corrah, T., Bennett, S., Wheeler, J., Huygen, K., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2249 · Cited by 404 · see citing works
Neutrophil apoptosis and the resolution of infection
Kennedy, A. D., & DeLeo, F. R. (2008) · Immunologic Research · doi:10.1007/s12026-008-8049-6 · Cited by 399 · see citing works
Shroff, K. E., Meslin, K., & Cebra, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3904-3913.1995 · Cited by 397 · see citing works
Rhee, K., Sethupathi, P., Driks, A., Lanning, D. K., & Knight, K. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.1118 · Cited by 375 · see citing works
Glycoprofiling with micro-arrays of glycoconjugates and lectins
Angeloni, S. (2004) · Glycobiology · doi:10.1093/glycob/cwh143 · Cited by 361 · see citing works
Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel
Langlands, S. J. (2004) · Gut · doi:10.1136/gut.2003.037580 · Cited by 359 · see citing works
Mode of Delivery – Effects on Gut Microbiota and Humoral Immunity
Huurre, A., Kalliomäki, M. A., Rautava, S., Rinne, M., Salminen, S., & Isolauri, E. (2007) · Neonatology · doi:10.1159/000111102 · Cited by 354 · see citing works
Gut microbiota and development of atopic eczema in 3 European birth cohorts
Adlerberth, I., Strachan, D. P., Matricardi, P. M., Ahrné, S., Orfei, L., Åberg, N., Perkin, M. R., Tripodi, S., Hesselmar, B., Saalman, R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.05.018 · Cited by 354 · see citing works
Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes
Goriely, S., Vincart, B., Stordeur, P., Vekemans, J., Willems, F., Goldman, M., & Wit, D. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2141 · Cited by 349 · see citing works
Heterogeneity of CD4<sup>+</sup> memory T cells: Functional modules for tailored immunity
Sallusto, F., & Lanzavecchia, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200939722 · Cited by 348 · see citing works
He, W., Liu, Q., Wang, L., Chen, W., Li, N., & Cao, X. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.01.022 · Cited by 340 · see citing works
Meydani, S. N., & Ha, W.-K. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.861 · Cited by 337 · see citing works
Smith, P. D., Smythies, L. E., Mosteller‐Barnum, M., Sibley, D. A., Russell, M. W., Merger, M., Sellers, M. T., Orenstein, J. M., Shimada, T., Graham, M. F., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2651 · Cited by 327 · see citing works
Andersson, B. A., Porras, O., Hanson, L. A., Lagergård, T., & Svanborg-Edén, C. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/153.2.232 · Cited by 327 · see citing works
Recent Advances on Structure, Metabolism, and Function of Human Milk Oligosaccharides
Bode, L. (2006) · Journal of Nutrition · doi:10.1093/jn/136.8.2127 · Cited by 311 · see citing works
Xu, W., He, B., Chiu, A., Chadburn, A., Shan, M., Buldys, M., Ding, A. H., Knowles, D. M., Santini, P. A., & Cerutti, A. (2007) · Nature Immunology · doi:10.1038/ni1434 · Cited by 305 · see citing works
Bifidobacterium and Lactobacillus DNA in the human placenta
Satokari, R. M., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02475.x · Cited by 304 · see citing works
Host resistance factors in human milk
Goldman, A. S., & Smith, C. W. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80453-6 · Cited by 296 · see citing works
Arslanoğlu, S., Moro, G. E., & Boehm, G. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2420 · Cited by 286 · see citing works
Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
Macpherson, A. J., Geuking, M. B., & McCoy, K. D. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02159.x · Cited by 283 · see citing works
Differences in Bifidobacterium flora composition in allergic and healthy infants
Ouwehand, A. C., Isolauri, E., He, F., Hashimoto, H., Benno, Y., & Salminen, S. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.115754 · Cited by 277 · see citing works
Cravioto, A., Tello, A., Villafán, H., J. Ruiz, Vedovo, S. D., & Neeser, J. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.6.1247 · Cited by 274 · see citing works
Breast Milk: A Source of Bifidobacteria for Infant Gut Development and Maturation?
Gueimonde, M., Laitinen, K., Salminen, S., & Isolauri, E. (2007) · Neonatology · doi:10.1159/000100088 · Cited by 273 · see citing works
Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., & Itoh, K. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3504-3511.1999 · Cited by 271 · see citing works
Umesaki, Y., Setoyama, H., Matsumoto, S., & Okada, Y. (1993) · PubMed Central · Cited by 270 · see citing works
Wolvers, D., Antoine, J.-M., Myllyluoma, E., Schrezenmeir, J., Szajewska, H., & Rijkers, G. T. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.113753 · Cited by 268 · see citing works
Assessment of the bacterial diversity of breast milk of healthy women by quantitative real-time PCR
Collado, M. C., Delgado, S., Maldonado‐Barragán, A., & Rodríguez, J. M. (2009) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2009.02567.x · Cited by 259 · see citing works
Lefrançois, L., & Goodman, T. G. (1989) · Science · doi:10.1126/science.2564701 · Cited by 256 · see citing works
Eiwegger, T., Stahl, B., Haidl, P., Schmitt, J., Boehm, G., Dehlink, E., Urbanek, R., & Szépfalusi, Z. (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.01062.x · Cited by 246 · see citing works
Rautava, S., Salminen, S., & Isolauri, E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508116282 · Cited by 244 · see citing works
The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics
Martı́n, R., Langa, S., Reviriego, C., Jiménez, E., Marı́n, M. L., Olivares, M. M., Bozá, J., Jiménez, J., Fernández, L., Xaus, J., et al. (2003) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2003.09.010 · Cited by 243 · see citing works
Probiotics for the prevention or treatment of allergic diseases
Prescott, S. L., & Björkstén, B. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.027 · Cited by 238 · see citing works
Soroosh, P., & Doherty, T. A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03114.x · Cited by 226 · see citing works
Bode, L., Kunz, C., Muhly-Reinholz, M., Mayer, K., Seeger, W., & Rudloff, S. (2004) · Thrombosis and Haemostasis · doi:10.1160/th04-01-0055 · Cited by 223 · see citing works
MILLARD, A. L., MERTES, P. M., ITTELET, D., VILLARD, F., JEANNESSON, P., & BERNARD, J. (2002) · Clinical and Experimental Immunology · doi:10.1046/j.0009-9104.2002.01977.x · Cited by 220 · see citing works
He, F., Ouwehand, A. C., Isolauri, E., Hashimoto, H., Benno, Y., & Salminen, S. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb01548.x · Cited by 220 · see citing works
Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture
Gibson, G. R., & Wang, X. (1994) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1994.tb06813.x · Cited by 219 · see citing works
Eiwegger, T., Stahl, B., Schmitt, J., Boehm, G., Gerstmayr, M., Pichler, J., Dehlink, E., Loibichler, C., Urbanek, R., & Szépfalusi, Z. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000139411.35619.b4 · Cited by 218 · see citing works
Lactobacillus GG in the Prevention of Nosocomial Gastrointestinal and Respiratory Tract Infections
Hojsak, I., Abdović, S., Szajewska, H., Milošević, M., Krznarić, Ž., & Kolaček, S. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2568 · Cited by 214 · see citing works
Neonatal dendritic cells are intrinsically biased against Th-1 immune responses
Langrish, C. L., Buddle, J. C., Thrasher, A. J., & Goldblatt, D. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01817.x · Cited by 211 · see citing works
Structural and Functional Aspects of Prebiotics Used in Infant Nutrition1,
Boehm, G., & Moro, G. E. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1818s · Cited by 202 · see citing works
The First Prebiotics in Humans
Coppa, G. V., Bruni, S., Morelli, L., Soldi, S., & Gabrielli, O. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128926.14285.25 · Cited by 202 · see citing works
van Hoffen, E., Ruiter, B., Faber, J., M’Rabet, L., Knol, E. F., Stahl, B., Arslanoğlu, S., Moro, G. E., Boehm, G., & Garssen, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01765.x · Cited by 200 · see citing works
Self-citationThibault, H., Aubert‐Jacquin, C., & Goulet, O. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200408000-00004 · Cited by 195 · see citing works
Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
Naarding, M. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25105 · Cited by 187 · see citing works
T cell-mediated immune responses in human newborns: ready to learn?
Marchant, A., & Goldman, M. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02799.x · Cited by 183 · see citing works
Deficiency of immune interferon production by leukocytes of normal newborns
Bryson, Y. J., Winter, H. S., Gard, S. E., Fischer, T. J., & Stiehm, E. R. (1980) · Cellular Immunology · doi:10.1016/0008-8749(80)90150-1 · Cited by 175 · see citing works
Natural killer cells remember: An evolutionary bridge between innate and adaptive immunity?
Sun, J. C.-Y., & Lanier, L. L. (2009) · European Journal of Immunology · doi:10.1002/eji.200939435 · Cited by 173 · see citing works
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis
van der Aa, L. B., van Aalderen, W. M. C., Heymans, H. S. A., Henk Sillevis Smitt, J., Nauta, A. J., Knippels, L. M. J., Ben Amor, K., Sprikkelman, A. B., & the Synbad Study Group (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02416.x · Cited by 172 · see citing works
Self-citationHoarau, C., Lagaraine, C., Martin, L., Velge-Roussel, F., & Lebranchu, Y. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.043 · Cited by 171 · see citing works
Newburg, D. S., Pickering, L. K., McCluer, R. H., & Cleary, T. G. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.5.1075 · Cited by 163 · see citing works
Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized‐controlled trial
van der Aa, L. B., Heymans, H. S. A., van Aalderen, W. M. C., Smitt, J. H. S., Knol, J., Amor, K. B., Goossens, D. A. M., Sprikkelman, A. B., & the Synbad Study Group (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03465.x · Cited by 160 · see citing works
Self-citationThe importance of the development of the intestinal microbiota in infancy
Vael, C., & Desager, K. (2009) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328332351b · Cited by 158 · see citing works
Modulation of colonic barrier function by the composition of the commensal flora in the rat
Garcia-Lafuente, A. M., Antolı́n, M., Guarner, F., Crespo, E., & Malagelada, J. R. (2001) · Gut · doi:10.1136/gut.48.4.503 · Cited by 156 · see citing works
Mullié, C., Yazourh, A., Thibault, H., Odou, M., Singer, E., Kalach, N., Kremp, O., & Romond, M. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000141955.47550.a0 · Cited by 151 · see citing works
Penders, J., Stobberingh, E. E., Thijs, C. T., Adams, H., Vink, C., van Ree, R., & van den Brandt, P. A. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02599.x · Cited by 148 · see citing works
Parassol, N., Freitas, M., Thoreux, K., Dalmasso, G., Bourdet‐Sicard, R., & Rampal, P. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.09.013 · Cited by 146 · see citing works
Aksu, G., Genel, F., Koturoğlu, G., Kurugöl, Z., & Kütükçüler, N. (2006) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2006.2590 · Cited by 146 · see citing works
Vos, A. P., Haarman, M., Buco, A., Govers, M. J., Knol, J., Garssen, J., Stahl, B., Boehm, G., & M’Rabet, L. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.010 · Cited by 136 · see citing works
Self-citationKalliomäki, M. A., Antoine, J., Herz, U., Rijkers, G. T., Wells, J. M., & Mercenier, A. (2010) · Journal of Nutrition · doi:10.3945/jn.109.113761 · Cited by 132 · see citing works
Summers, K. L., Huffnagle, G. B., Noverr, M. C., & Kao, J. Y. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9_1 · Cited by 131 · see citing works
Puccio, G., Cajozzo, C., Meli, F., Rochat, F., Grathwohl, D., & Steenhout, P. G. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.007 · Cited by 128 · see citing works
Rowe, J., Macaubas, C., Monger, T., Holt, B. J., Harvey, J., POOLMAN, J. T., Sly, P. D., & Holt, P. G. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.3873-3877.2000 · Cited by 125 · see citing works
Survival of Human Milk Oligosaccharides in the Intestine of Infants
Chaturvedi, P., Warren, C. D., Buescher, C., Pickering, L. K., & Newburg, D. S. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1371-1_39 · Cited by 124 · see citing works
Food allergy: separating the science from the mythology
Brandtzæg, P. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.80 · Cited by 124 · see citing works
Sazawal, S., Dhingra, U., Hiremath, G. S., Sarkar, A., Dhingra, P., Dutta, A., Verma, P., Menon, V. P., & Black, R. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012164 · Cited by 123 · see citing works
Probiotics in inflammatory bowel disease: possible mechanisms of action.
Dotan, I., & Rachmilewitz, D. (2005) · PubMed · Cited by 121 · see citing works
Prebiotic carbohydrates in human milk and formulas
Boehm, G., Stahl, B., Jelinek, J., Knol, J., Miniello, V. L., & Moro, G. E. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb02149.x · Cited by 119 · see citing works
Self-citationProbiotics and prebiotics: clinical effects in allergic disease
Tang, M. L. K., Lahtinen, S. J., & Boyle, R. J. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32833d9728 · Cited by 116 · see citing works
Vos, A. P., Haarman, M., VanGinkel, J. H., Knol, J., Garssen, J., Stahl, B., Boehm, G., & M’Rabet, L. (2007) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2007.00515.x · Cited by 112 · see citing works
Self-citationComparative Analysis of Fecal Microbiota in Infants with and without Eczema
Hong, P., Lee, B. W., Aw, M., Shek, L. P., Yap, G. C., Chua, K. Y., & Liu, W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009964 · Cited by 112 · see citing works
Milk-Derived Transforming Growth Factor-β and the Infant Immune Response
Penttila, I. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.016 · Cited by 108 · see citing works
Hatcher, G. E., & Lambrecht, R. S. (1993) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(93)77583-9 · Cited by 104 · see citing works
Strober, W., Kelsall, B., & Marth, T. (1998) · Journal of Clinical Immunology · doi:10.1023/a:1023222003039 · Cited by 104 · see citing works
Romagnani, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.005 · Cited by 92 · see citing works
Vinderola, G., Matar, C., Palacios, J., & Perdigón, G. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.10.020 · Cited by 91 · see citing works
Qin, H. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i17.2591 · Cited by 91 · see citing works
Obermeier, S., Rudloff, S., Pohlentz, G., Lentze, M. J., & Kunz, C. (1999) · Isotopes in Environmental and Health Studies · doi:10.1080/10256019908234084 · Cited by 87 · see citing works
Yabuhara, A., Kawal, H., & Komiyama, A. (1990) · Pediatric Research · doi:10.1203/00006450-199010000-00002 · Cited by 85 · see citing works
Mode of delivery and cord blood cytokines: a birth cohort study
Ly, N. P., Ruiz‐Perez, B., Onderdonk, A. B., Tzianabos, A. O., Litonjua, A. A., Liang, C., Laskey, D. H., Delaney, M. L., DuBois, A. M., Levy, H., et al. (2006) · Clinical and Molecular Allergy · doi:10.1186/1476-7961-4-13 · Cited by 82 · see citing works
Sazawal, S., Dhingra, U., Hiremath, G. S., Sarkar, A., Dhingra, P., Dutta, A., Menon, V. P., & Black, R. E. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181d98e45 · Cited by 80 · see citing works
Ko, J. S. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i13.1962 · Cited by 78 · see citing works
Vinderola, G., Matar, C., & Perdigón, G. (2007) · Immunobiology · doi:10.1016/j.imbio.2006.09.003 · Cited by 73 · see citing works
Stahl, B., Thurl, S., Henker, J., Siegel, M., Finke, B., & Sawatzki, G. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1371-1_37 · Cited by 72 · see citing works
Immunological Parameters: What Do They Mean?1,
Calder, P. C. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.773s · Cited by 72 · see citing works
Miyawaki, T., Seki, H., Taga, K., Sato, H., & Taniguchi, N. (1985) · PubMed Central · Cited by 71 · see citing works
Induction of Antigen-Specific Immunity in Human Neonates and Infants
Wilson, C. B., & Kollmann, T. R. (2008) · KARGER eBooks · doi:10.1159/000113493 · Cited by 60 · see citing works
The Delivery of Probiotics and Prebiotics to Infants
Kullen, M. J., & Bettler, J. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382359 · Cited by 60 · see citing works
Practical prebiotics, probiotics and synbiotics for allergists: how useful are they?
Johannsen, H., & Prescott, S. L. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03368.x · Cited by 60 · see citing works
Bacterial Translocation from the Intestines
Berg, R. D. (1985) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim1978.34.1_1 · Cited by 53 · see citing works
The Hygiene Hypothesis: Do We Still Believe in It?
Björkstén, B. (2009) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000235780 · Cited by 51 · see citing works
Fermented Infant Formulae Without Live Bacteria
Agostoni, C. V., Goulet, O., Kolaček, S., Koletzko, B. V., Moreno, L. A., Puntis, J. W. L., Rigo, J., Shamir, R., Szajewska, H., & Turck, D. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000258887.93866.69 · Cited by 46 · see citing works
Commensal bacteria shape intestinal immune system development
Cash, H. L., & Hooper, L. V. (2005) · ASM news · Cited by 38 · see citing works
PASTORELLI, G., Rousset, F., Pène, J., Péronne, C., Roncarolo, M., Tovo, P., & de Vries, J. E. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05413.x · Cited by 38 · see citing works
Clinical Use of Probiotics in the Pediatric Population
Wallace, B. I. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533608329298 · Cited by 38 · see citing works
Expression and Regulation of L-Selectin on Eosinophils from Human Adults and Neonates
Smith, J. B., Kunjummen, R. D., Kishimoto, T., & Anderson, D. C. (1992) · Pediatric Research · doi:10.1203/00006450-199210000-00018 · Cited by 38 · see citing works
Specific prebiotic oligosaccharides modulate the early phase of a murine vaccination response
Vos, A. P., Knol, J., Stahl, B., M’Rabet, L., & Garssen, J. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.02.014 · Cited by 37 · see citing works
Self-citationProbiotics for allergic respiratory diseases – Putting it into perspective
Singh, M., & Das, R. R. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00921.x · Cited by 37 · see citing works
Björkstén, B. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832abfc2 · Cited by 36 · see citing works
Picaud, J., Chapalain, V., Paineau, D., Zourabichvili, O., Bornet, F. R. J., & Duhamel, J.-F. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2010.01896.x · Cited by 35 · see citing works
Differential responses of cord and adult blood‐derived dendritic cells to dying cells
Wong, O. H., Huang, F., & Chiang, A. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02191.x · Cited by 32 · see citing works
Effects of Acetate on Human Immune System
Ishizaka, S., Kikuchi, E., & Tsujii, T. (1993) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979309025991 · Cited by 27 · see citing works
Opportunities for Improving the Health and Nutrition of the Human Infant by Probiotics
Salminen, S., & Isolauri, E. (2008) · Nestlé Nutrition Workshop series. Pediatric program/Nestlé Nutrition Workshop series. Paediatric program · doi:10.1159/000146350 · Cited by 24 · see citing works
Chorioamnionitis, Surfactant, and Lung Disease in Very Low Birth Weight Infants
Jobe, A. H., & Kallapur, S. G. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.08.009 · Cited by 24 · see citing works
Tang, M. L. K., & Kemp, A. S. (1995) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.1995.tb00251.x · Cited by 23 · see citing works
A Novel Genetic Label for Detection of Specific Probiotic Lactic Acid Bacteria
Fernández, L., Marin, M. L., Langa, S., Martı́n, R., Reviriego, C., Fernandez, A., Olivares, M. M., Xaus, J., & Rodríguez, J. M. (2004) · Food Science and Technology International · doi:10.1177/1082013204043761 · Cited by 16 · see citing works
Postnatal effects of obstetrical epidural anesthesia on allergic sensitization
Kirjavainen, P. V., Kalliomäki, M. A., Salminen, S., & Isolauri, E. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01259.x · Cited by 7 · see citing works
Hypertriglyceridemia and insulin resistance
Stefanović, Golubović, E., Vlahović, V., & Mitic'‐Zlatkovic' (1998) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1998.00245.x · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 164 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of the gut microbiota in nutrition and health
Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,203 · see citing works
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
Cristofori, F., Dargenio, V. N., Dargenio, C., Miniello, V. L., Barone, M., & Francavilla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.578386 · Cited by 958 · see citing works
The gut microbiota and obesity: from correlation to causality
Zhao, L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3089 · Cited by 847 · see citing works
The Gut Microbiota in the First Decade of Life
Derrien, M., Alvarez, A., & de Vos, W. M. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.08.001 · Cited by 648 · see citing works
Antibiotics in early life and obesity
Cox, L. M., & Blaser, M. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.210 · Cited by 543 · see citing works
Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works
Gut microbiome and liver diseases
Tilg, H., Cani, P. D., & Mayer, E. A. (2016) · Gut · doi:10.1136/gutjnl-2016-312729 · Cited by 525 · see citing works
Moeser, A. J., Pohl, C. S., & Rajput, M. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.06.003 · Cited by 452 · see citing works
The first thousand days - intestinal microbiology of early life: Establishing a symbiosis
Wopereis, H., Oozeer, R., Knipping, K., Belzer, C., & Knol, J. (2014) · Pediatric Allergy and Immunology · doi:10.1111/pai.12232 · Cited by 352 · see citing works
Self-citationMorrow, A. L., Lagomarcino, A. J., Schibler, K. R., Taft, D. H., Yu, Z., Wang, B., Altaye, M., Wagner, M., Gevers, D., Ward, D. V., et al. (2013) · Microbiome · doi:10.1186/2049-2618-1-13 · Cited by 342 · see citing works
Intestinal dysbiosis and probiotic applications in autoimmune diseases
de Oliveira, G. L. V., Leite, A. Z., Higuchi, B. S., Gonzaga, M. I., & Mariano, V. S. (2017) · Immunology · doi:10.1111/imm.12765 · Cited by 321 · see citing works
The Human Neonatal Gut Microbiome: A Brief Review
Gritz, E. C., & Bhandari, V. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2015.00017 · Cited by 309 · see citing works
Highly Variable Microbiota Development in the Chicken Gastrointestinal Tract
Stanley, D., Geier, M. S., Hughes, R., Denman, S. E., & Moore, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084290 · Cited by 304 · see citing works
Ageing and gut microbes: Perspectives for health maintenance and longevity
Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276 · see citing works
The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals
Weström, B. R., Sureda, E. A., Pierzynowska, K. G., Pierzynowski, S. G., & Pérez-Cano, F. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01153 · Cited by 257 · see citing works
Microbiota of Cow’s Milk; Distinguishing Healthy, Sub-Clinically and Clinically Diseased Quarters
Oikonomou, G., Bicalho, M. L. S., Meira, E. B. S., Rossi, R. E., Foditsch, C., Machado, V. S., Teixeira, A. G. V., Santisteban, C. G., Schukken, Y. H., & Bicalho, R. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085904 · Cited by 245 · see citing works
Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development
Lee, H., Padhi, E. M. T., Hasegawa, Y., Larke, J. A., Parenti, M., Wang, A., Hernell, O., Lönnerdal, B. L., & Slupsky, C. M. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00313 · Cited by 231 · see citing works
Morphogenesis and maturation of the embryonic and postnatal intestine
Chin, A. M., Hill, D. R., Aurora, M., & Spence, J. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.01.011 · Cited by 222 · see citing works
Early environments and the ecology of inflammation
McDade, T. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202244109 · Cited by 218 · see citing works
The Early Settlers: Intestinal Microbiology in Early Life
Scholtens, P. A. M. J., Oozeer, R., Martı́n, R., Amor, K. B., & Knol, J. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022811-101120 · Cited by 220 · see citing works
Self-citationModulation of bone remodeling by the gut microbiota: A new therapy for osteoporosis
Lyu, Z., Hu, Y., Guo, Y., & Liu, D. (2023) · Bone Research · doi:10.1038/s41413-023-00264-x · Cited by 207 · see citing works
Impact of Early-Life Exposures on Immune Maturation and Susceptibility to Disease
Gollwitzer, E. S., & Marsland, B. J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.09.009 · Cited by 205 · see citing works
Hakim, H., Dallas, R. H., Wolf, J., Tang, L., Schultz‐Cherry, S., Darling, V. R., Johnson, C. N., Karlsson, E. A., Chang, T., Jeha, S., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy153 · Cited by 193 · see citing works
Akkerman, R., Faas, M. M., & de Vos, P. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1414030 · Cited by 177 · see citing works
The Preterm Gut Microbiota: An Inconspicuous Challenge in Nutritional Neonatal Care
Henderickx, J. G. E., Zwittink, R. D., van Lingen, R. A., Knol, J., & Belzer, C. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00085 · Cited by 173 · see citing works
Self-citationCeliberto, L. S., Graef, F. A., Healey, G. R., Bosman, E. S., Jacobson, K., Sly, L. M., & Vallance, B. A. (2018) · Immunology · doi:10.1111/imm.12939 · Cited by 167 · see citing works
Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development
Ayechu-Muruzabal, V., van Stigt, A. H., Mank, M., Willemsen, L. E. M., Stahl, B., Garssen, J., & Land, B. V. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00239 · Cited by 170 · see citing works
Self-citationEffects of prebiotics on immune system and cytokine expression
Shokryazdan, P., Jahromi, M. F., Navidshad, B., & Liang, J. B. (2016) · Medical Microbiology and Immunology · doi:10.1007/s00430-016-0481-y · Cited by 161 · see citing works
Diet and microbiota in inflammatory bowel disease: The gut in disharmony
Rapozo, D. C. M., Bernardazzi, C., & de Souza, H. S. P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i12.2124 · Cited by 160 · see citing works
Shu, S.-A., Yuen, A. W. T., Woo, E., Chu, K. H., Kwan, H. S., Yang, G., Yang, Y., & Leung, P. S. C. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8723-y · Cited by 160 · see citing works
Örtqvist, Å., Lundholm, C., Kieler, H., Ludvigsson, J. F., Fall, T., Ye, W., & Almqvist, C. (2014) · BMJ · doi:10.1136/bmj.g6979 · Cited by 149 · see citing works
Role of the Human Breast Milk-Associated Microbiota on the Newborns’ Immune System: A Mini Review
Toscano, M., Grandi, R. D., Grossi, E., & Drago, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02100 · Cited by 145 · see citing works
Probiotic Therapy as a Novel Approach for Allergic Disease
Toh, Z. Q., Anzela, A., Tang, M. L. K., & Licciardi, P. V. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00171 · Cited by 130 · see citing works
Animal models of herpes simplex virus immunity and pathogenesis
Kollias, C. M., Huneke, R. B., Wigdahl, B. L., & Jennings, S. R. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0302-2 · Cited by 119 · see citing works
Gut microbiota and obesity: lessons from the microbiome
Cani, P. D. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt014 · Cited by 117 · see citing works
Chua, M. C., Ben‐Amor, K., Lay, C., Goh, A. E. N., Chiang, W. C., Rao, R., Chew, C., Chaithongwongwatthana, S., Khemapech, N., Knol, J., et al. (2017) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001623 · Cited by 117 · see citing works
Self-citationComposition and diverse differences of intestinal microbiota in ulcerative colitis patients
Zhu, S., Han, M., Liu, S., Fan, L., Shi, H., & Li, P. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.953962 · Cited by 117 · see citing works
Marcotte, E. L., Thomopoulos, T., Infante-Rivard, C., Clavel, J., Petridou, E., Schüz, J., Ezzat, S., Dockerty, J., Metayer, C., Magnani, C., et al. (2016) · The Lancet Haematology · doi:10.1016/s2352-3026(16)00002-8 · Cited by 110 · see citing works
Emergence and significance of carbohydrate-specific antibodies
Kappler, K., & Hennet, T. (2020) · Genes and Immunity · doi:10.1038/s41435-020-0105-9 · Cited by 113 · see citing works
Infant Formula Supplemented with Biotics: Current Knowledge and Future Perspectives
Salminen, S., Stahl, B., Vinderola, G., & Szajewska, H. (2020) · Nutrients · doi:10.3390/nu12071952 · Cited by 113 · see citing works
Nauta, A. J., Amor, K. B., Knol, J., Garssen, J., & van der Beek, E. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.039644 · Cited by 110 · see citing works
Self-citationAlizadeh, A., Akbari, P., Difilippo, E., Schols, H. A., Ulfman, L. H., Schoterman, M. H. C., Garssen, J., Fink‐Gremmels, J., & Braber, S. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004997 · Cited by 106 · see citing works
Self-citationAltitude influences microbial diversity and herbage fermentation in the rumen of yaks
Fan, Q., Wanapat, M., Yan, T., & Hou, F. (2020) · BMC Microbiology · doi:10.1186/s12866-020-02054-5 · Cited by 111 · see citing works
Cao, W., Wang, C., Chin, Y., Chen, X., Gao, Y., Yuan, S., Xue, C., Wang, Y., & Tang, Q. (2018) · Food & Function · doi:10.1039/c8fo01404c · Cited by 104 · see citing works
Gut Microbiota Implications for Health and Welfare in Farm Animals: A Review
Chen, S., Luo, S., & Yan, C. (2021) · Animals · doi:10.3390/ani12010093 · Cited by 106 · see citing works
Atkinson, M. A., & Chervonsky, A. V. (2012) · Diabetologia · doi:10.1007/s00125-012-2672-4 · Cited by 90 · see citing works
Sławińska, A., Dunisławska, A., Płowiec, A., Radomska, M., Lachmanska, J., Siwek, M. Z., Tavaniello, S., & Maiorano, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212318 · Cited by 88 · see citing works
Lehmann, S., Hiller, J., van Bergenhenegouwen, J., Knippels, L. M. J., Garssen, J., & Traidl‐Hoffmann, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132304 · Cited by 88 · see citing works
Self-citationMotherway, M. O., Kinsella, M., Fitzgerald, G. F., & van Sinderen, D. (2012) · Microbial Biotechnology · doi:10.1111/1751-7915.12011 · Cited by 87 · see citing works
The impact of postnatal antibiotics on the preterm intestinal microbiome
Dardas, M., Gill, S. R., Grier, A., Pryhuber, G., Gill, A. L., Lee, Y., & Guillet, R. (2014) · Pediatric Research · doi:10.1038/pr.2014.69 · Cited by 83 · see citing works
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 79 · see citing works
Bacteriophages as New Human Viral Pathogens
Tetz, G. V., & Tetz, V. (2018) · Microorganisms · doi:10.3390/microorganisms6020054 · Cited by 82 · see citing works
Evolution of animal immunity in the light of beneficial symbioses
Gerardo, N. M., Hoang, K. L., & Stoy, K. S. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0601 · Cited by 79 · see citing works
Development of Microbiota in Infants and its Role in Maturation of Gut Mucosa and Immune System
Ximénez, C., & Torres, J. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.007 · Cited by 81 · see citing works
Necrotizing enterocolitis in premature infants and newborns
Mϋller, M. J., Paul, T., & Seeliger, S. (2016) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-16915130 · Cited by 77 · see citing works
Coker, M. O., Laue, H. E., Hoen, A. G., Hilliard, M. A., Dade, E. F., Li, Z., Palys, T. J., Morrison, H. G., Baker, E., Karagas, M. R., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.642197 · Cited by 75 · see citing works
Gut mycobiome: The probable determinative role of fungi in IBD patients
Maal, A. B., Shahrokh, S., Ansari, S., Mirsamadi, E. S., Yadegar, A., Mirjalali, H., & Zali, M. R. (2021) · Mycoses · doi:10.1111/myc.13238 · Cited by 71 · see citing works
Zhang, Y., Choi, S. H., Nogoy, K. M. C., & Liang, S. (2021) · animal · doi:10.1016/j.animal.2021.100316 · Cited by 72 · see citing works
Forsberg, M. M., Björkander, S., Pang, Y., Lundqvist, L., Ndi, M., Ott, M., Escribá, I. B., Jaeger, M.-C., Roos, S., & Sverremark‐Ekström, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-53576-6 · Cited by 70 · see citing works
Intestinal Microbial Diversity and Perioperative Complications
Ralls, M. W., Miyasaka, E. A., & Teitelbaum, D. H. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486482 · Cited by 69 · see citing works
Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants
Hickman, B., Salonen, A., Ponsero, A. J., Jokela, R., Kolho, K., de Vos, W. M., & Korpela, K. (2024) · Nature Communications · doi:10.1038/s41467-024-52561-6 · Cited by 73 · see citing works
Current status of laboratory and imaging diagnosis of neonatal necrotizing enterocolitis
D’Angelo, G., Impellizzeri, P., Marseglia, L. M., Montalto, A. S., Russo, T., Salamone, I., Falsaperla, R., Corsello, G., Romeo, C., & Gitto, E. (2018) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-018-0528-3 · Cited by 65 · see citing works
Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity
McKeen, S., Young, W., Mullaney, J. A., Fraser, K., McNabb, W. C., & Roy, N. C. (2019) · Nutrients · doi:10.3390/nu11020364 · Cited by 65 · see citing works
Shaping the Infant Microbiome With Non-digestible Carbohydrates
Verkhnyatskaya, S. A., Ferrari, M. D. L., de Vos, P., & Walvoort, M. T. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00343 · Cited by 64 · see citing works
The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy
Nguyen, Q. N., Himes, J. E., Martinez, D. R., & Permar, S. R. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005997 · Cited by 64 · see citing works
[Prebiotics: concept, properties and beneficial effects].
Corzo, N., Alonsó, J. L., Azpiroz, F., Torras, M. D. L. Á. C., Cirici, M., Leis, R., Lombó, F., Mateos‐Aparicio, I., Plou, F. J., Ruas‐Madiedo, P., et al. (2015) · PubMed · doi:10.3305/nh.2015.31.sup1.8715 · Cited by 67 · see citing works
Urwin, H. J., Miles, E. A., Noakes, P. S., Kremmyda, L.-S., Vlachava, M., Diaper, N. D., Godfrey, K. M., Calder, P. C., Vulevic, J., & Yaqoob, P. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003097 · Cited by 61 · see citing works
Associations between bacterial communities of house dust and infant gut
Konya, T., Koster, B., Maughan, H., Escobar, M. D., Azad, M. B., Guttman, D. S., Sears, M. R., Becker, A. B., Brook, J. R., Takaro, T. K., et al. (2014) · Environmental Research · doi:10.1016/j.envres.2014.02.005 · Cited by 61 · see citing works
Composition and stability of intestinal microbiota of healthy children within a Dutch population
de Meij, T. G. J., Budding, A. E., de Groot, E. F. J., Jansen, F. M., Kneepkens, C. M. F., Benninga, M. A., Penders, J., Bodegraven, A. A. V., & Savelkoul, P. H. M. (2015) · The FASEB Journal · doi:10.1096/fj.15-278622 · Cited by 60 · see citing works
Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life
Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 58 · see citing works
Infancy Dietary Patterns, Development, and Health: An Extensive Narrative Review
Martín-Rodríguez, A., Bustamante-Sánchez, Á., Martínez‐Guardado, I., Navarro-Jiménez, E., Plata-SanJuan, E., Tornero-Aguilera, J. F., & Clemente‐Suárez, V. J. (2022) · Children · doi:10.3390/children9071072 · Cited by 58 · see citing works
Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins
Cozen, W., Yu, G., Gail, M. H., Ridaura, V. K., Nathwani, B. N., Hwang, A. E., Hamilton, A. S., Mack, T. M., Gordon, J. I., & Goedert, J. J. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.60 · Cited by 58 · see citing works
Zwittink, R. D., van Zoeren‐Grobben, D., Martı́n, R., van Lingen, R. A., Jebbink, L. J. G., Boeren, S. A., Renes, I. B., van Elburg, R. M., Belzer, C., & Knol, J. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000102 · Cited by 58 · see citing works
Self-citationMa, L., Xu, S., Liu, H., Xu, T., Hu, L., Zhao, N., Han, X., & Zhang, X. (2019) · PeerJ · doi:10.7717/peerj.7645 · Cited by 58 · see citing works
Desselberger, U. (2018) · Pathogens · doi:10.3390/pathogens7030057 · Cited by 55 · see citing works
DeVries, A., McCauley, K. E., Fadrosh, D. W., Fujimura, K. E., Stern, D. A., Lynch, S. V., & Vercelli, D. (2022) · Allergy · doi:10.1111/all.15442 · Cited by 54 · see citing works
Developmental programming of aging trajectory
Vaiserman, A. M., Koliada, A. K., & Lushchak, O. V. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.007 · Cited by 57 · see citing works
Hogenkamp, A., Thijssen, S., van Vlies, N., & Garssen, J. (2014) · Journal of Nutrition · doi:10.3945/jn.114.197707 · Cited by 54 · see citing works
Self-citationTeague, K. D., Graham, D. B., Dunn, J. R., Cheng, H. H., Anthony, N. B., Latorre, J. D., Menconi, A., Wolfenden, R., Wolfenden, A. D., Mahaffey, B. D., et al. (2017) · Poultry Science · doi:10.3382/ps/pew494 · Cited by 54 · see citing works
Tian, S., Wang, J., Yu, H., Wang, J., & Zhu, W. (2019) · Nutrients · doi:10.3390/nu11081753 · Cited by 54 · see citing works
Prentice, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01641 · Cited by 52 · see citing works
Ortega, V. A., Mercer, E. M., Giesbrecht, G. F., & Arrieta, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.634539 · Cited by 51 · see citing works
Microbial regulation of allergic responses to food
Feehley, T., Stefka, A. T., Cao, S. Z., & Nagler‐Anderson, C. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0337-5 · Cited by 48 · see citing works
Eck, A., Rutten, N. B. M. M., Singendonk, M. M. J., Rijkers, G. T., Savelkoul, P. H. M., Meijssen, C. B., Crijns, C. E., Oudshoorn, J. H., Budding, A. E., & Vlieger, A. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228133 · Cited by 50 · see citing works
Teng, T., Gao, F., He, W., Fu, H., Guo, J., Bai, G., & Shi, B. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00545 · Cited by 50 · see citing works
Fernández, L., Ruíz, L., Jara, J., Orgaz, B., & Rodríguez, J. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02676 · Cited by 48 · see citing works
Daele, E. V., Knol, J., & Belzer, C. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1680601 · Cited by 48 · see citing works
Self-citationNecrotizing enterocolitis: The road to zero
Kim, J. H. (2013) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2013.10.001 · Cited by 47 · see citing works
Comparison of Gut Microbiota of Yaks From Different Geographical Regions
Liu, W., Wang, Q., Song, J., Xin, J.-W., Zhang, S., Lei, Y., Yang, Y., Xie, P., & Suo, H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.666940 · Cited by 46 · see citing works
Noninvasive molecular fingerprinting of host–microbiome interactions in neonates
Donovan, S. M., Wang, M., Monaco, M. H., Martin, C. R., Davidson, L. A., Ivanov, I. V., & Chapkin, R. S. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.07.008 · Cited by 45 · see citing works
Henderickx, J. G. E., Zwittink, R. D., Renes, I. B., van Lingen, R. A., van Zoeren‐Grobben, D., Jebbink, L. J. G., Boeren, S. A., van Elburg, R. M., Knol, J., & Belzer, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-92222-y · Cited by 43 · see citing works
Self-citationCastro, J. J., Gomez, A. M., White, B. A., Mangian, H. J., Loften, J. R., & Drackley, J. K. (2016) · Journal of Dairy Science · doi:10.3168/jds.2016-11006 · Cited by 41 · see citing works
Wang, W., Wang, W., Du, Y., Wu, H. Y., Yu, X., Ye, K.-P., Li, C., Jung, Y., Qian, Y., Voglmeir, J., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.026 · Cited by 41 · see citing works
Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome
Silva, L. H. A. C., Galvão, J. G. F. M., da Silva, J. S. D. F., de Sales-Neto, J. M., & Rodrigues‐Mascarenhas, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00341 · Cited by 40 · see citing works
Cheng, R., Li, M., Li, S. S., He, M., Yu, X. H., Shi, L., & He, F. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx104 · Cited by 40 · see citing works
Celiberto, L. S., Pinto, R. A., Rossi, E. A., Vallance, B. A., & Cavallini, D. C. U. (2018) · Nutrients · doi:10.3390/nu10111684 · Cited by 42 · see citing works
Yan, Y., Xu, B., Yin, B., Xu, X., Niu, Y., Tang, Y., Wang, X., Xie, C., Yang, T., Zhou, S., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.03125 · Cited by 39 · see citing works
Early gut microbiota intervention in premature infants: Application perspectives
Xiang, Q., Yan, X., Shi, W., Li, H., & Zhou, K. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.11.004 · Cited by 43 · see citing works
Severe viral respiratory infections: are bugs bugging?
Vissers, M., de Groot, R., & Ferwerda, G. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.93 · Cited by 37 · see citing works
Regulation of Allergic Immune Responses by Microbial Metabolites
Park, H. J., Lee, S. W., & Hong, S. (2018) · Immune Network · doi:10.4110/in.2018.18.e15 · Cited by 38 · see citing works
- Authors
- Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J.
- Affiliations
- Danone (Netherlands) (NL)
- Danone Research, Center for Specialised Nutrition, P.O. Box 7005, 6700 CA Wageningen, the Netherlands
- Utrecht University (NL)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2010-11-01
- Volume
- 1
- Issue
- 4
- Pages
- 367-382
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2106985367
- Cited by
- 338
- References
- 164
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 16 · 2023: 30 · 2022: 30 · 2021: 32 · 2020: 38 · 2019: 29 · 2018: 36 · 2017: 27 · 2016: 10 · 2015: 25 · 2014: 17 · 2013: 18 · 2012: 13
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Beneficial Microbes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, infant immune development, host-microbe interactions, commensal microorganisms, microbial colonization, immune system maturation, prebiotics, probiotics, synbiotics, necrotizing enterocolitis, atopic dermatitis, inflammatory and autoimmune diseases
- MeSH terms
- Child Development, Humans, Immune System, Infant, Gastrointestinal Tract, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review