The DOI matches its Crossref record.
Reduction of Oropharyngeal Carriage of Haemophilus influenzae Type b (Rib) in Children Immunized with an Rib Conjugate Vaccine
Abstract
The oropharyngeal carriage of Haemophilus influenzae type b (Hib) was studied among 725 healthy 3-year-old children who had or had not been immunized with an Hib conjugate vaccine. Oropharyngeal swabs were collected during the childrens' well-child visit to their local child health center. Fourteen (3.5%) of the 398 unvaccinated children were oropharyngeal carriers of Hib, whereas none of the 327 children who had received Hib conjugate vaccine carried Hib (P less than .001). Carriage rates of non-type b H. influenzae (19%) or Streptococcus pneumoniae (18%) were the same irrespective of the Hib vaccination status of the children. Thus Hib conjugate vaccine, unlike Hib polysaccharide vaccine, seems to be able to prevent oropharyngeal colonization by Hib.
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Citations
Cited by
Peltola, H. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.2.302-317.2000 · Cited by 1,364
Decline of Childhood Haemophilus influenzae Type b (Hib) Disease in the Hib Vaccine Era
Adams, W. G. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500020055031 · Cited by 696
Clarke, S. R., Brummell, K. J., Horsburgh, M. J., McDowell, P. W., Mohamad, S. A. S., Stapleton, M. R., Acevedo, J., Read, R. C., Day, N. P. J., Peacock, S. J., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/501471 · Cited by 208
WENGER, J. D. (1998) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199809001-00008 · Cited by 153
Metadata
- Authors
- Takala, A. K., Eskola, J., Leinonen, M., Kayhty, H., Nissinen, A., Pekkanen, E., & Makela, P. H.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-11-01
- Volume
- 164
- Issue
- 5
- Pages
- 982-986
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2313083727
- Cited by
- 377
- References
- 0
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduction of Oropharyngeal Carriage of Haemophilus influenzae Type b (Rib) in Children Immunized with an Rib Conjugate Vaccine. https://app.cochat.ai/papers/10.1093/infdis/164.5.982
- The paper
- Takala, A. K., Eskola, J., Leinonen, M., Kayhty, H., Nissinen, A., Pekkanen, E., & Makela, P. H. (1991). Reduction of Oropharyngeal Carriage of Haemophilus influenzae Type b (Rib) in Children Immunized with an Rib Conjugate Vaccine. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/164.5.982
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
