The DOI matches its Crossref record.
Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients
Abstract
Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, < 30 days) than in adults (> 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.
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Cited by
Taur, Y., Jenq, R. R., Perales, M.-A., Littmann, E. R., Morjaria, S., Ling, L., No, D., Gobourne, A., Viale, A., Dahi, P. B., et al. (2014) · Blood · doi:10.1182/blood-2014-02-554725 · Cited by 885
Adenoviruses in Immunocompromised Hosts
Echavarría, M. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-07 · Cited by 512
Efficient Gene Transfer into Human CD34 + Cells by a Retargeted Adenovirus Vector
Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G., & Lieber, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2567-2583.2000 · Cited by 367
Metadata
- Authors
- Flomenberg, P., Babbitt, J., Drobyski, W. R., Ash, R. C., Carrigan, D. R., Sedmak, G. V., McAuliffe, T., Camitta, B., Horowitz, M. M., Bunin, N., & Casper, J. T.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-04-01
- Volume
- 169
- Issue
- 4
- Pages
- 775-781
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2059875959
- Cited by
- 355
- References
- 0
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients. https://app.cochat.ai/papers/10.1093/infdis/169.4.775
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- Flomenberg, P., Babbitt, J., Drobyski, W. R., Ash, R. C., Carrigan, D. R., Sedmak, G. V., McAuliffe, T., Camitta, B., Horowitz, M. M., Bunin, N., & Casper, J. T. (1994). Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/169.4.775
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