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Cited by 512

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Adenoviruses in Immunocompromised Hosts

Open access
Echavarría, Marcela·2008·Clinical Microbiology Reviews
DOI 10.1128/cmr.00052-07
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Abstract

SUMMARY: The number of patients with acquired immunodeficiency has grown steadily as a result of both a larger number of patients receiving solid organ and hematopoietic stem cell transplants and their longer survival times. The use of newer, more potent immunosuppressive regimens has increased the frequency of severe adenovirus infections. Human adenoviruses are a large group of viruses, represented by at least 52 serotypes with various genotypes divided into genomic clusters, and these may cause a broad variety of clinical manifestations. The development of molecular methods has increased the sensitivity and rapidity of adenovirus infection diagnosis. The implementation of PCR assays has significantly contributed to the identification of patients with disseminated adenovirus disease. More recently, the development of real-time PCR assays has permitted virus quantification and patient follow-up. There is no treatment for adenovirus with demonstrated efficacy, although cidofovir is widely used. Sensitive diagnostic tests for adenovirus can contribute to the early diagnosis and successful treatment of life-threatening adenovirus infections, especially in complex immunocompromised patients. The development of improved adenovirus therapy still remains a challenge. Adenovirus genetic diversity should be considered for diagnosis, typing, and therapeutic interventions.

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Metadata

Authors
Echavarría, M.
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
2008-10
Volume
21
Issue
4
Pages
704-715
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.00052-07
OpenAlex
W2022636501
Cited by
512
References
39
FWCI
14.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Adenoviruses in Immunocompromised Hosts. https://app.cochat.ai/papers/10.1128/cmr.00052-07
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Echavarría, M. (2008). Adenoviruses in Immunocompromised Hosts. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00052-07

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