The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Paromomycin for Cryptosporidiosis in AIDS: A Prospective, Double-Blind Trial
Abstract
To test the effects of paromomycin, 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial. After 14 days, patients were switched to the other treatment for 14 additional days. Measures included the number and character of each stool and weekly 24-h stool specimens for weight and oocyst excretion. During the paromomycin treatment phase, oocyst excretion decreased from 314 x 10(6) to 109 x 10(6)24 h (P < .02). Oocyst excretion increased for the 4 patients initially on placebo compared to a median decrease of 128 x 10(6)/24 h for the 6 initially treated with drug (P < .02). Stool frequency also decreased more in those treated with drug (3.6 fewer vs. 1.25 fewer/24 h, P < .05). Trends favored drug over placebo for stool weight, stool character, and Karnofsky score. Paromomycin treatment resulted in improvement in both clinical and parasitologic parameters in cryptosporidiosis in AIDS.
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Citations
Cites
The Two-Period Crossover Design in Medical Research
Woods, J. R., Williams, J. G., & Tavel, M. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-7-560 · Cited by 139
Cited by
Practice Guidelines for the Management of Infectious Diarrhea
Guerrant, R. L., Van Gilder, T., Steiner, T. S., Thielman, N. M., Slutsker, L., Tauxe, R. V., Hennessy, T., Griffin, P. M., DuPont, H., Bradley Sack, R., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/318514 · Cited by 1,074
Checkley, W., White, A. C., Jaganath, D., Arrowood, M. J., Chalmers, R. M., Chen, X.-M., Fayer, R., Griffiths, J. K., Guerrant, R. L., Hedstrom, L., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70772-8 · Cited by 987
Chen, X.-M., Keithly, J. S., Paya, C. V., & LaRusso, N. F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra013170 · Cited by 451
Amadi, B., Mwiya, M., Musuku, J., Watuka, A., Sianongo, S., Ayoub, A., & Kelly, P. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11401-2 · Cited by 441
Cryptosporidium and cryptosporidiosis
Havens, P. L., & Davis, J. P. (1996) · Seminars in Pediatric Infectious Diseases · doi:10.1016/s1045-1870(96)80016-1 · Cited by 428
Metadata
- Authors
- Clinton White Jr., A., Chappell, C. L., Sikander Hayat, C., Kimball, K. T., Flanigan, T. P., & Goodgame, R. W.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-08-01
- Volume
- 170
- Issue
- 2
- Pages
- 419-424
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2323061991
- Cited by
- 189
- References
- 1
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Paromomycin for Cryptosporidiosis in AIDS: A Prospective, Double-Blind Trial. https://app.cochat.ai/papers/10.1093/infdis/170.2.419
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- Clinton White Jr., A., Chappell, C. L., Sikander Hayat, C., Kimball, K. T., Flanigan, T. P., & Goodgame, R. W. (1994). Paromomycin for Cryptosporidiosis in AIDS: A Prospective, Double-Blind Trial. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/170.2.419
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
