The DOI matches its Crossref record.
Retrospective And Prospective Studies Of Hemorrhagic Fever With Renal Syndrome In Rural China
Abstract
Residents of two villages in Zhejiang Province, China, were interviewed and serum samples were collected to assess prevalence of hantavirus infection. Antibody prevalence was 12% (219/1811), with a ratio of illness to infection of 1.0:5.4. Seroprevalence increased with age, but no association was found with sex. There was also no evidence of vertical transmission. One year later, 2.3% (30/1325) of seronegative subjects had seroconverted including 2 who had hemorrhagic fever with renal syndrome. Peak incidence of infection occurred in those 15-39 years old. Hantaan was the dominant serotype; Seoul serotype was less common (5:1). Host reservoirs were Apodemus agrarius in agricultural fields and Rattus norvegicus in houses. Risk factors for infection were traces of rat-contaminated food, travel to other areas for farm work, direct rodent contact, camping in grain fields, living in a house on the periphery of a village, stacking straw stacks outside houses, and keeping cats. All may provide exposure to infectious rodent reservoirs.
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Evidence from comparative studies does not support human-to-human transmission of hantavirus infection, with the exception of 1 prospective cohort study in Chile with serious risk of bias and no unexposed comparison group.
“Evidence from comparative studies (the strongest level of evidence available) does not support human-to-human transmission of hantavirus infection [12, 15, 27, 34, 36, 38], with the exception of 1 prospective cohort study in Chile with serious RoB and no unexposed comparison group [29].”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
In Ruo 1994, family clustering was analyzed by binomial distribution fit procedure in the cross-sectional sample in 1987, and no clustering was found (χ2 = 0.59, 1 df, P = .44).
“Family clustering was analyzed by binomial distribution fit procedure in the cross-sectional sample in 1987; no clustering was found (χ 2 = 0.59, 1 df, P = .44).”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
In Ruo 1994, a multivariate analysis of risk factors in each of the cross-sectional and cohort studies found a significant risk for 3-4 factors associated with rodent exposure.
“A multivariate analysis of risk factors in each of the cross-sectional and cohort studies found a significant risk for 3–4 factors associated with rodent exposure.”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
In Ruo 1994, 30 of 1325 (2.3%) residents who were IgG-seronegative in 1987 seroconverted between 1987 and 1988.
“Thirty of 1325 (2.3%) residents who were IgG-seronegative in 1987 seroconverted between 1987 and 1988.”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
In Ruo 1994, caring for others with HFRS did not show a significant relationship with IgG positivity in the univariate analysis and was not included in the multivariate analysis.
“Caring for others with HFRS did not show a significant relationship with IgG positivity in the univariate analysis (data not shown) and was not included in the multivariate analysis.”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
In Ruo 1994, there was no evidence for human-to-human transmission of hantavirus.
“No evidence for human-to-human transmission.”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [34]
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Epidemiology of Hantavirus infections in humans: A comprehensive, global overview
Watson, D. C., Sargianou, M., Papa, A., Chra, P., Starakis, I., & Panos, G. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.783555 · Cited by 204
Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review
Toledo, J., Haby, M. M., Reveiz, L., Sosa Leon, L., Angerami, R., & Aldighieri, S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab461 · Cited by 78
“The RoB in included studies is a particular concern when trying to determine whether human-to-human transmission of hantavirus is the best explanation for infection in other human contacts.”
BackgroundInfluential
Metadata
- Authors
- Ruo, S. L., Li, Y. L., Tong, Z., Ma, Q. R., Liu, Z. L., Tang, Y. W., Ye, K. L., Xu, Z. Y., McCormick, J. B., & Fisher-Hoch, S. P.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Ruo, S. L.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-09-01
- Volume
- 170
- Issue
- 3
- Pages
- 527-534
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2335244541
- Cited by
- 50
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2017: 2 · 2016: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Keywords
- hemorrhagic fever with renal syndrome, hantavirus, seroprevalence, Hantaan virus, Seoul virus, Apodemus agrarius, Rattus norvegicus, rodent reservoirs, zoonotic transmission, risk factors, seroconversion, rural villages, Zhejiang
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Animals, Animals, Domestic, Cats, Child, Child, Preschool, China, Cross-Sectional Studies, Family, Female, Food Contamination, Hemorrhagic Fever with Renal Syndrome, Humans, Infant, Male, Middle Aged, Prospective Studies, Retrospective Studies, Risk Factors, Rural Population, Sex Factors, Socioeconomic Factors, Prevalence, Rats
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