The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Protection of Dogs from Lyme Disease with a Vaccine Containing Outer Surface Protein (Osp) A, OspB, and the Saponin Adjuvant QS21
Open accessAbstract
A vaccine consisting of purified Escherichia coli-expressed recombinant full-length outer surface proteins A (OspA) and B (OspB) and the saponin adjuvant QS21 was evaluated for protection against Borrelia burgdorferi infection. Eleven beagles were vaccinated twice and then challenged with 10 field-collected adult female Ixodes scapularis. Xenodiagnosis revealed that all 11 nonvaccinated control dogs and 2 of 10 vaccinated dogs were infected with B. burgdorferi. Six of 11 control dogs also developed fever (0.75 +/- 0.38 degrees C) and were lethargic. One of the control dogs also developed a limp. Both of the infected vaccinated dogs were asymptomatic. Thus, the vaccine prevented tick-vectored infection and associated symptoms of Lyme disease.
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Three of the studies reporting adverse events noted mild swelling and reddening at the injection site.
“Three of these studies noted mild swelling and reddening at the injection site.1, 30, 32”
From Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis (2019) · cites this paper as [30]
Citations
Cites
The Biological and Social Phenomenon of Lyme Disease
Barbour, A. G., & Fish, D. (1993) · Science · doi:10.1126/science.8503006 · Cited by 638
Self-citationConspecificity of the Ticks Ixodes scapularis and I. dammini (Acari: Ixodidae)
Oliver, J. H., Owsley, M. R., Hutcheson, H. J., et al. (1993) · Journal of Medical Entomology · doi:10.1093/jmedent/30.1.54 · Cited by 239
Experimental Lyme Disease in Dogs Produces Arthritis and Persistent Infection
Appel, M. J. G., Allan, S., Jacobson, R. H., Lauderdale, T. L., Chang, Y., Shin, S. J., Thomford, J. W., Todhunter, R. J., & Summers, B. A. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.3.651 · Cited by 221
Schwartz, I. S., Wormser, G. P., Schwartz, J. J., et al. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.12.3082-3088.1992 · Cited by 220
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice
Fikrig, E., Barthold, S. W., Marcantonio, N., et al. (1992) · Infection and Immunity · doi:10.1128/iai.60.2.657-661.1992 · Cited by 169
Mather, T. N., Telford, S. R., MOORE, S. I., et al. (1990) · Experimental Parasitology · doi:10.1016/0014-4894(90)90085-q · Cited by 102
Self-citationImmunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin
Chu, H.-J., Chavez, L. G., Blumer, B. M., et al. (1992) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1992.201.03.403 · Cited by 70
Ma, J., Bulger, P. A., Davis, D. V., et al. (1994) · Vaccine · doi:10.1016/0264-410x(94)90036-1 · Cited by 43
Self-citationMa, J., Bulger, P. A., Dante, S., et al. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.4.909 · Cited by 20
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Safety, efficacy and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine
Ma, J., Hine, P. M., Clough, E. R., Fish, D., Coughlin, R. T., Beltz, G. A., & Shew, M. G. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00045-x · Cited by 21
Self-citationVogt, N. A., Sargeant, J. M., MacKinnon, M. C., & Versluis, A. M. (2019) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15344 · Cited by 16
“Three of these studies noted mild swelling and reddening at the injection site.(1,30,32) One of these studies reported that 8 of 10 dogs had a slight swelling at the injection site at the 1st vaccination and 3 of the 10 dogs had a similar FIGURE 1 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analy…”
Background
Metadata
- Authors
- Coughlin, R. T., Fish, D., Mather, T. N., Ma, J., Pavia, C., & Bulger, P.
- Corresponding author
- Coughlin, R. T.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-04-01
- Volume
- 171
- Issue
- 4
- Pages
- 1049-1052
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2114759766
- Cited by
- 45
- References
- 9
- Citations by year
- 2021: 1 · 2018: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Journal of Media Literacy Education (submittedVersion, cc-by)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Infectious Diseases › Brucella: diagnosis, epidemiology, treatment
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Lyme disease, dogs, Borrelia burgdorferi, OspA, OspB, outer surface proteins, recombinant protein vaccine, Ixodes scapularis, tick-borne diseases, xenodiagnosis, vaccine efficacy, asymptomatic infection
- MeSH terms
- Adjuvants, Immunologic, Animals, Antibodies, Bacterial, Antigens, Bacterial, Antigens, Surface, Bacterial Outer Membrane Proteins, Bacterial Vaccines, Dogs, Female, Immunoglobulin G, Lipoproteins, Lyme Disease, Male, Saponins, Ticks, Vaccination, Vaccines, Synthetic, Borrelia burgdorferi Group
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