The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Irreversible Effects of Ivermectin on Adult Parasites in Onchocerciasis Patients in the Onchocerciasis Control Programme in West Africa
Abstract
Ivermectin is an effective drug for the treatment of human onchocerciasis, a disease caused by the parasitic filarial nematode Onchocerca volvulus. When humans are treated, the microfilariae normally found in the skin are rapidly and very nearly completely eliminated. Nonetheless, after a delay, microfilariae gradually reappear in the skin. This study is concerned with the causes of this delay. Hypotheses are tested by comparing the results of model calculations with skin microfilaria counts collected from 114 patients during a trial of five annual treatments in the focus area of Asubende, Ghana. The results obtained strongly suggest that annual treatment with ivermectin causes an irreversible decline in microfilariae production of approximately 30%/treatment. This result has important implications for public health strategies designed to eliminate onchocerciasis as a significant health hazard.
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Cites
A Simplex Method for Function Minimization
Nelder, J. A., & Mead, R. (1965) · The Computer Journal · doi:10.1093/comjnl/7.4.308 · Cited by 28,905
Cited by
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Public–private partnerships for public health
Reich, M. R. (2000) · Nature Medicine · doi:10.1038/76176 · Cited by 269
Moxidectin: an oral treatment for human onchocerciasis
Milton, P., Hamley, J. I. D., Walker, M., & Basáñez, M.-G. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1792772 · Cited by 211
Metadata
- Authors
- Plaisier, A. P., Alley, E. S., Boatin, B. A., Van Oortmarssen, G. J., Remme, H., De Vias, S. J., Bonneux, L., & Habbema, J. D. F.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-07-01
- Volume
- 172
- Issue
- 1
- Pages
- 204-210
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2084881364
- Cited by
- 242
- References
- 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Irreversible Effects of Ivermectin on Adult Parasites in Onchocerciasis Patients in the Onchocerciasis Control Programme in West Africa. https://app.cochat.ai/papers/10.1093/infdis/172.1.204
- The paper
- Plaisier, A. P., Alley, E. S., Boatin, B. A., Van Oortmarssen, G. J., Remme, H., De Vias, S. J., Bonneux, L., & Habbema, J. D. F. (1995). Irreversible Effects of Ivermectin on Adult Parasites in Onchocerciasis Patients in the Onchocerciasis Control Programme in West Africa. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/172.1.204
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
