Moxidectin: an oral treatment for human onchocerciasis

Milton, Philip; Hamley, Jonathan I. D.; Walker, Martin; Basáñez, María-Gloria

doi:10.1080/14787210.2020.1792772

Cited by 211Parasitic Diseases Research and TreatmentParasites and Host InteractionsResearch on Leishmaniasis Studies

Moxidectin: an oral treatment for human onchocerciasis

Open access

Milton, Philip, Hamley, Jonathan I. D., Walker, Martin, Basáñez, María-Gloria·2020·Expert Review of Anti-infective Therapy

DOI 10.1080/14787210.2020.1792772

Open this paper in CoChat — free account Open PDF

Abstract

INTRODUCTION: Moxidectin is a milbemycin endectocide recently approved for the treatment of human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a filarial infection endemic in Africa, Yemen, and the Amazonian focus straddling Venezuela and Brazil. Concerns over whether the predominant treatment strategy (yearly mass drug administration (MDA) of ivermectin) is sufficient to achieve elimination in all endemic foci have refocussed attention upon alternative treatments. Moxidectin's stronger and longer microfilarial suppression compared to ivermectin in both phase II and III clinical trials indicates its potential as a novel powerful drug for onchocerciasis elimination. AREAS COVERED: This work summarizes the chemistry and pharmacology of moxidectin, reviews the phase II and III clinical trials evidence on tolerability, safety, and efficacy of moxidectin versus ivermectin, and discusses the implications of moxidectin's current regulatory status. EXPERT OPINION: Moxidectin's superior clinical performance has the potential to substantially reduce times to elimination compared to ivermectin. If donated, moxidectin could mitigate the additional programmatic costs of biannual ivermectin distribution because, unlike other alternatives, it can use the existing community-directed treatment infrastructure. A pediatric indication (for children <12 years) and determination of its usefulness in onchocerciasis-loiasis co-endemic areas will greatly help fulfill the potential of moxidectin for the treatment and elimination of onchocerciasis.

Integrity signals

Registry

Crossref · 10.1080/14787210.2020.1792772

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Some veterinary antibiotics were first approved in animals.
“However, some were first approved in animals (14).”
From DrugCentral 2023 extends human clinical data and integrates veterinary drugs (2023) · cites this paper as [14]
Nearly all veterinary antibiotics were first approved in humans.
“Nearly all veterinary antibiotics were first approved in humans.”
From DrugCentral 2023 extends human clinical data and integrates veterinary drugs (2023) · cites this paper as [14]
The antibiotic moxidectin, initially approved for animal use, was later approved for humans.
“This is not always true: the antibiotic moxidectin, initially approved for animal use, was later approved for humans (14).”
From DrugCentral 2023 extends human clinical data and integrates veterinary drugs (2023) · cites this paper as [14]

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,112 · see citing works
Principles of activation and permeation in an anion-selective Cys-loop receptor
Hibbs, R. E., & Gouaux, E. (2011) · Nature · doi:10.1038/nature10139 · Cited by 997 · see citing works
Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
Agwuh, K. N. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl224 · Cited by 805 · see citing works
Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection
Gardon, J., Gardon-Wendel, N., Demanga-Ngangue, Kamgno, J., Chippaux, J., & Boussinesq, M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)11094-1 · Cited by 746 · see citing works
Moxidectin and the avermectins: Consanguinity but not identity
Prichard, R., Ménez, C., & Lespine, A. (2012) · International Journal for Parasitology: Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2012.04.001 · Cited by 439 · see citing works
Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics
Wolstenholme, A. J., & Rogers, A. T. (2005) · Parasitology · doi:10.1017/s0031182005008218 · Cited by 435 · see citing works
Wolbachia.Bacterial Endosymbionts of Filarial Nematodes
Taylor, M. J., Bandi, C., & Hoerauf, A. M. (2005) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(05)60004-8 · Cited by 425 · see citing works
The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review
Canga, A. G., Sahagún, A. M., Diez, M. J., Fernández, N., Sierra, M., & Garcia, J. J. (2008) · The AAPS Journal · doi:10.1208/s12248-007-9000-9 · Cited by 419 · see citing works
River Blindness: A Success Story under Threat?
Basáñez, M.-G., Pion, S. D. S., Churcher, T. S., Breitling, L. P., Little, M. P., & Boussinesq, M. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030371 · Cited by 369 · see citing works
Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis
Basáñez, M.-G., Pion, S. D. S., Boakes, E., Filipe, J. A. N., Churcher, T. S., & Boussinesq, M. (2008) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(08)70099-9 · Cited by 336 · see citing works
A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa –Endemic Areas
Kamgno, J., Pion, S. D. S., Chesnais, C. B., Bakalar, M. H., D’Ambrosio, M. V., Mackenzie, C. D., Nana-Djeunga, H. C., Gounoue-Kamkumo, R., Njitchouang, G.-R., Nwane, P. B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1705026 · Cited by 298 · see citing works
Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial
Opoku, N. O., Bakajika, D. K., Kanza, E. M., Howard, H., Mambandu, G., Nyathirombo, A., Nigo, M. M., Kasonia, K., Masembe, S. L., Mumbere, M., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32844-1 · Cited by 298 · see citing works
Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment
Hoerauf, A. M., Mand, S., Adjei, O., Fleischer, B., & Büttner, D. W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04581-5 · Cited by 282 · see citing works
Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial
Gardon, J., Boussinesq, M., Kamgno, J., Gardon-Wendel, N., Demanga-Ngangue, & Duke, B. O. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09456-4 · Cited by 282 · see citing works
Alternative treatment strategies to accelerate the elimination of onchocerciasis
Boussinesq, M., Fobi, G., & Kuesel, A. C. (2017) · International Health · doi:10.1093/inthealth/ihx054 · Cited by 245 · see citing works
Irreversible Effects of Ivermectin on Adult Parasites in Onchocerciasis Patients in the Onchocerciasis Control Programme in West Africa
Plaisier, A. P., Alley, E. S., Boatin, B., van Oortmarssen, G. J., Remme, H., Vias, S. J. D., Bonneux, L. G. A., & Habbema, J. D. F. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.1.204 · Cited by 242 · see citing works
Progress toward elimination of onchocerciasis in the Americas
Sauerbrey, M., Rakers, L., & Richards, F. O. (2017) · International Health · doi:10.1093/inthealth/ihx039 · Cited by 241 · see citing works
A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection
Awadzi, K., Opoku, N. O., Attah, S. K., Lazdins-Helds, J. K., & Kuesel, A. C. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002953 · Cited by 233 · see citing works
Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis
Stolk, W. A., Walker, M., Coffeng, L. E., Basáñez, M.-G., & de Vlas, S. J. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-1159-9 · Cited by 232 · see citing works
Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis
Tan, K. R., Magill, A. J., Parise, M. E., & Arguin, P. M. (2011) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2011.10-0285 · Cited by 229 · see citing works
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
Doyle, S. R., Bourguinat, C., Nana-Djeunga, H. C., Kengne-Ouafo, J. A., Pion, S. D. S., Bopda, J. G., Kamgno, J., Wanji, S., Che, H., Kuesel, A. C., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005816 · Cited by 215 · see citing works
Identifying sub-optimal responses to ivermectin in the treatment of River Blindness
Churcher, T. S., Pion, S. D. S., Osei-Atweneboana, M. Y., Prichard, R. K., Awadzi, K., Boussinesq, M., Collins, R. C., WHITWORTH, J. A. G., & Basáñez, M.-G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906176106 · Cited by 214 · see citing works
P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance
Lespine, A., Menez, C., Bourguinat, C., & Prichard, R. K. (2011) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2011.10.001 · Cited by 202 · see citing works
The impact of five years of annual ivermectin treatment on skin microfilarial loads in the onchocerciasis focus of Asubende, Ghana
Alley, E. S., Plaisier, A. P., Boatin, B., Dadzie, K. Y., Remme, J. H. F., Zerbo, G., & SAMBA, E. M. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90172-4 · Cited by 202 · see citing works
Research for new drugs for elimination of onchocerciasis in Africa
Kuesel, A. C. (2016) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2016.04.002 · Cited by 199 · see citing works
Compliance with eight years of annual ivermectin treatment of onchocerciasis in Cameroon and Nigeria
Brieger, W. R., Okeibunor, J., Abiose, A. O., Wanji, S., Elhassan, E. O., Ndyomugyenyi, R., & Amazigo, U. V. (2011) · Parasites & Vectors · doi:10.1186/1756-3305-4-152 · Cited by 196 · see citing works
Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?
Frempong, K. K., Walker, M., Cheke, R., Tettevi, E. J., Gyan, E. T., Owusu, E. O., Wilson, M. D., Boakye, D. A., Taylor, M. J., Biritwum, N., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw144 · Cited by 196 · see citing works
The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data
Turner, H. C., Walker, M., Attah, S. K., Opoku, N. O., Awadzi, K., Kuesel, A. C., & Basáñez, M.-G. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-0779-4 · Cited by 194 · see citing works
Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness
Walker, M., Pion, S. D. S., Fang, H., Gardon, J., Kamgno, J., Basáñez, M.-G., & Boussinesq, M. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix616 · Cited by 194 · see citing works
Ivermectin: Reduction in Prevalence and Infection Intensity of Onchocerca Volvulus Following Biannual Treatments in five Guatemalan Communities
Collins, R. C., Gonzales-Peralta, C., de Castro, J. S., Zea-Flores, G., Cupp, M. S., Richards, F. O., & Cupp, E. W. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.47.156 · Cited by 189 · see citing works
Managing the Fight against Onchocerciasis in Africa: APOC Experience
Fobi, G., Yaméogo, L., Noma, M., Aholou, Y., Koroma, J. B., Zouré, H., Ukety, T., Lusamba-Dikassa, P.-S., Mwikisa, C. N., Boakye, D. A., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003542 · Cited by 182 · see citing works
Interaction of macrocyclic lactones with P-glycoprotein: Structure–affinity relationship
Lespine, A., Martin, S., Dupuy, J., Roulet, A., Pineau, T., Orlowski, S., & Alvinerie, M. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.10.004 · Cited by 182 · see citing works
Dynamics of Onchocerca volvulus Microfilarial Densities after Ivermectin Treatment in an Ivermectin-naïve and a Multiply Treated Population from Cameroon
Pion, S. D. S., Nana-Djeunga, H. C., Kamgno, J., Tendongfor, N., Wanji, S., Njiokou, F., Prichard, R. K., & Boussinesq, M. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002084 · Cited by 180 · see citing works
Relationship between oral declaration on adherence to ivermectin treatment and parasitological indicators of onchocerciasis in an area of persistent transmission despite a decade of mass drug administration in Cameroon
Wanji, S., Kengne-Ouafo, J. A., Esum, M. E., Ndongmo, W. P. C., Fovennso, B. A., Eyong, J. E. E., Jato, I., Datchoua-Poutcheu, F. R., Abong, R. A., Enyong, P. I., et al. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-1283-6 · Cited by 175 · see citing works
Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
Moreno, Y., Nabhan, J. F., Solomon, J., Mackenzie, C. D., & Geary, T. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011983107 · Cited by 173 · see citing works
Ongoing Transmission of Onchocerca volvulus after 25 Years of Annual Ivermectin Mass Treatments in the Vina du Nord River Valley, in North Cameroon
Eisenbarth, A., Achukwi, M. D., & Renz, A. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004392 · Cited by 169 · see citing works
Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin
Komlan, K., Voßberg, P., Gantin, R. G., Solim, T., Korbmacher, F., Banla, M., Padjoudoum, K., Karabou, P., Köhler, C., & Soboslay, P. T. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006312 · Cited by 167 · see citing works
Cattle protected from onchocerciasis by ivermectin are highly susceptible to infection after drug withdrawal
Njongmeta, L. M., Nfon, C. K., Gilbert, J., Makepeace, B. L., Tanya, V. N., & Trees, A. J. (2004) · International Journal for Parasitology · doi:10.1016/j.ijpara.2004.04.011 · Cited by 156 · see citing works
Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments
Bottomley, C., Isham, V. S., Collins, R. C., & Basáñez, M.-G. (2008) · Parasitology · doi:10.1017/s0031182008000425 · Cited by 156 · see citing works
Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial
Turner, J. D., Tendongfor, N., Esum, M. E., Johnston, K. L., Langley, R. S., Ford, L., Faragher, B. E., Specht, S., Mand, S., Hoerauf, A. M., et al. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000660 · Cited by 155 · see citing works
Refugia and anthelmintic resistance: Concepts and challenges
Hodgkinson, J. E., Kaplan, R. M., Kenyon, F., Morgan, E. R., PARK, A. W., Paterson, S., Babayan, S. A., Beesley, N. J., Britton, C., Chaudhry, U. N., et al. (2019) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2019.05.001 · Cited by 148 · see citing works
Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana
Awadzi, K., Attah, S. K., Addy, E. T., Opoku, N. O., Quartey, B., Lazdins-Helds, J. K., Ahmed, K., Boatin, B., Boakye, D. A., & Edwards, G. (2004) · Annals of Tropical Medicine and Parasitology · doi:10.1179/000349804225003442 · Cited by 145 · see citing works
Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance
Prichard, R. K., & Geary, T. G. (2019) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2019.06.002 · Cited by 144 · see citing works
Anti- Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
Taylor, M. J., Hoerauf, A. M., Townson, S., Slatko, B. E., & Ward, S. A. (2013) · Parasitology · doi:10.1017/s0031182013001108 · Cited by 143 · see citing works
Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment
Tamarozzi, F., Halliday, A., Gentil, K., Hoerauf, A. M., Pearlman, E. M., & Taylor, M. J. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00057-10 · Cited by 140 · see citing works
Mutations in the extracellular domains of glutamate‐gated chloride channel α3 and β subunits from ivermectin‐resistant Cooperia oncophora affect agonist sensitivity
Njue, A., Hayashi, J. H., Kinne, L. P., Feng, X., & Prichard, R. K. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02379.x · Cited by 138 · see citing works
Individuals living in an onchocerciasis focus and treated three-monthly with ivermectin develop fewer new onchocercal nodules than individuals treated annually
Campillo, J. T., Chesnais, C. B., Pion, S. D. S., Gardon, J., Kamgno, J., & Boussinesq, M. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04126-x · Cited by 138 · see citing works
The Antiparasitic Moxidectin: Safety, Tolerability, and Pharmacokinetics in Humans
Cotreau, M. M., Warren, S., Ryan, J. L., Fleckenstein, L. L., Vanapalli, S. R., Brown, K. R., Rock, D., Chen, C., & Schwertschlag, U. S. (2003) · The Journal of Clinical Pharmacology · doi:10.1177/0091270003257456 · Cited by 137 · see citing works
Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon
Wanji, S., Tendongfor, N., Nji, T., Esum, M. E., Che, J. N., Nkwescheu, A. S., Alassa, F., Kamnang, G., Enyong, P., Taylor, M. J., et al. (2009) · Parasites & Vectors · doi:10.1186/1756-3305-2-39 · Cited by 117 · see citing works
The Mazzotti Reaction Following Treatment of Onchocerciasis with Diethylcarbamazine: Clinical Severity as a Function of Infection Intensity
Francis, H. F., Awadzi, K., & Ottesen, E. A. (1985) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1985.34.529 · Cited by 114 · see citing works
Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness
Walker, M., Specht, S., Churcher, T. S., Hoerauf, A. M., Taylor, M. J., & Basáñez, M.-G. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu1152 · Cited by 113 · see citing works
Prophylactic Activity of Tetracycline against Brugia pahangi Infection in Jirds (Meriones unguiculatus)
Bosshardt, S. C., McCall, J. W., Coleman, S. U., Jones, K. L., Petit, T. A., & Klei, T. R. (1993) · Journal of Parasitology · doi:10.2307/3283620 · Cited by 98 · see citing works
Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: “The Worminator”
Storey, B., Marcellino, C., Miller, M., Maclean, M. J., Mostafa, E., Howell, S., Sakanari, J. A., Wolstenholme, A. J., & Kaplan, R. M. (2014) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2014.08.003 · Cited by 96 · see citing works
Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes in Caenorhabditis elegans
Zhao, Z., Sheps, J. A., Ling, V. W. T., Fang, L. L., & Baillie, D. L. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.09.052 · Cited by 94 · see citing works
Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin
Ardelli, B. F., & Prichard, R. K. (2012) · Veterinary Parasitology · doi:10.1016/j.vetpar.2012.09.021 · Cited by 90 · see citing works
Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
Taylor, M. J., von Geldern, T. W., Ford, L., Hübner, M. P., Marsh, K. C., Johnston, K. L., Sjoberg, H. T., Specht, S., Pionnier, N. P., Tyrer, H. E., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau2086 · Cited by 87 · see citing works
Selamectin is a potent substrate and inhibitor of human and canine P‐glycoprotein
Griffin, J., Fletcher, N. F., Clemence, R. G., BLANCHFLOWER, S. E., & Brayden, D. J. (2005) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2005.00655.x · Cited by 83 · see citing works
Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones
Geyer, J., & Janko, C. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800399301 · Cited by 82 · see citing works
Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility
Janssen, I. J. I., Krücken, J., Demeler, J., Basiaga, M., Kornaś, S. A., & von Samson‐Himmelstjerna, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061635 · Cited by 82 · see citing works
Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice
Kiki-Mvouaka, S., Menez, C., Borin, C., Lyazrhi, F., Foucaud-Vignault, M., Dupuy, J., Collet, X., Alvinerie, M., & Lespine, A. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.030700 · Cited by 82 · see citing works
Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial
Debrah, A. Y., Specht, S., Klarmann‐Schulz, U., Debrah, L. B., Mand, S., Marfo‐Debrekyei, Y., Fimmers, R., Dubben, B., Kwarteng, A., Osei-Atweneboana, M. Y., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ363 · Cited by 81 · see citing works
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Aljayyoussi, G., Tyrer, H. E., Ford, L., Sjoberg, H. T., Pionnier, N. P., Waterhouse, D., Davies, J. D., Gamble, J., Metuge, H., Cook, D. A. N., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00322-5 · Cited by 78 · see citing works
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus
Doyle, S. R., Illingworth, C. J. R., Laing, R., Bartley, D. J., Redman, E., Martinelli, A., Holroyd, N. E., Morrison, A. A., Rezansoff, A., Tracey, A., et al. (2019) · BMC Genomics · doi:10.1186/s12864-019-5592-6 · Cited by 77 · see citing works
Transmission of Onchocerciasis in Wadelai Focus of Northwestern Uganda Has Been Interrupted and the Disease Eliminated
Katabarwa, M. N., Walsh, F., Habomugisha, P., Lakwo, T., Agunyo, S., Oguttu, D. W., Unnasch, T. R., Unoba, D., Byamukama, E., Tukesiga, E., et al. (2012) · Journal of Parasitology Research · doi:10.1155/2012/748540 · Cited by 74 · see citing works
AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis
Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., Cassidy, A., Cook, D. A. N., Siu, A., Shiotani, M., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816585116 · Cited by 73 · see citing works
Pharmacokinetics of the macrocyclic lactones: conventional wisdom and new paradigms.
Hennessy, D. R., & Alvinerie, M. (2002) · CABI Publishing eBooks · doi:10.1079/9780851996172.0097 · Cited by 71 · see citing works
From river blindness control to elimination: bridge over troubled water
Colebunders, R., Basáñez, M.-G., Siling, K., Post, R. J., Rotsaert, A., Mmbando, B. P., Suykerbuyk, P., & Hopkins, A. (2018) · Infectious Diseases of Poverty · doi:10.1186/s40249-018-0406-7 · Cited by 69 · see citing works
Comparison of doxycycline, minocycline, doxycycline plus albendazole and albendazole alone in their efficacy against onchocerciasis in a randomized, open-label, pilot trial
Klarmann-Schulz, U., Specht, S., Debrah, A. Y., Batsa, L., Ayisi-Boateng, N. K., Osei-Mensah, J., Mubarik, Y., Konadu, P., Ricchiuto, A., Fimmers, R., et al. (2017) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0005156 · Cited by 63 · see citing works
The end of a dogma: the safety of doxycycline use in young children for malaria treatment
Gaillard, T., Briolant, S., Madamet, M., & Pradines, B. (2017) · Malaria Journal · doi:10.1186/s12936-017-1797-9 · Cited by 63 · see citing works
Fifteen Years of Annual Mass Treatment of Onchocerciasis with Ivermectin Have Not Interrupted Transmission in the West Region of Cameroon
Katabarwa, M. N., Eyamba, A., Nwane, P. B., Enyong, P., Kamgno, J., Kuété, T., Yaya, S., Aboutou, R., Mukenge, L., Kafando, C. M., et al. (2013) · Journal of Parasitology Research · doi:10.1155/2013/420928 · Cited by 62 · see citing works
Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans
Janssen, I. J. I., Krücken, J., Demeler, J., & von Samson‐Himmelstjerna, G. (2015) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2015.03.003 · Cited by 59 · see citing works
Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: Influence of the route of administration on the activity against resistant Haemonchus contortus in lambs
Lloberas, M., Álvarez, L., Entrocasso, C., Virkel, G., Lanusse, C., & Lifschitz, A. (2012) · Experimental Parasitology · doi:10.1016/j.exppara.2012.04.014 · Cited by 59 · see citing works
Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis
Turner, H. C., Churcher, T. S., Walker, M., Osei-Atweneboana, M. Y., Prichard, R. K., & Basáñez, M.-G. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002169 · Cited by 56 · see citing works
Albendazole and antibiotics synergize to deliver short-course anti- Wolbachia curative treatments in preclinical models of filariasis
Turner, J. D., Sharma, R., Jayoussi, G. A., Tyrer, H. E., Gamble, J., Hayward, L., Priestley, R. S., Murphy, E. A., Davies, J. D., Waterhouse, D., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710845114 · Cited by 56 · see citing works
Audit of the community-directed treatment with ivermectin (CDTI) for onchocerciasis and factors associated with adherence in three regions of Cameroon
Kamga, G.-R., Dissak‐Delon, F. N., Nana-Djeunga, H. C., Biholong, B. D., Ghogomu, S. M., Souopgui, J., Kamgno, J., & Robert, A. R. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-2944-z · Cited by 55 · see citing works
Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda
Jacob, B. G., Loum, D., Lakwo, T., Katholi, C. R., Habomugisha, P., Byamukama, E., Tukahebwa, E. M., Cupp, E. W., & Unnasch, T. R. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006702 · Cited by 54 · see citing works
How do the macrocyclic lactones kill filarial nematode larvae?
Wolstenholme, A. J., Maclean, M. J., Coates, R., McCoy, C. J., & Reaves, B. J. (2016) · Invertebrate Neuroscience · doi:10.1007/s10158-016-0190-7 · Cited by 52 · see citing works
Excretion of Moxidectin into Breast Milk and Pharmacokinetics in Healthy Lactating Women
Korth-Bradley, J. M., Parks, V., Chalon, S., Gourley, I. S., Matschke, K. T., Gossart, S., Bryson, P., & Fleckenstein, L. L. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00311-11 · Cited by 49 · see citing works
High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms
Li, B. W., Rush, A. C., & Weil, G. J. (2014) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2014.01.002 · Cited by 46 · see citing works
Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes
Dadzie, Y., Amazigo, U. V., Boatin, B. A., & Seketeli, A. (2018) · Infectious Diseases of Poverty · doi:10.1186/s40249-018-0446-z · Cited by 46 · see citing works
Haemonchus contortus P-glycoprotein-2: in situ localisation and characterisation of macrocyclic lactone transport
Godoy, P., Lian, J., Beech, R. N., & Prichard, R. K. (2014) · International Journal for Parasitology · doi:10.1016/j.ijpara.2014.09.008 · Cited by 45 · see citing works
Les niveaux d'endémicité dans l'onchocercose
Prost, A., Hervouët, J.-P., & Thylefors, B. (1979) · Bulletin of the World Health Organization · Cited by 44 · see citing works
Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis
Tamarozzi, F., Tendongfor, N., Enyong, P., Esum, M. E., Faragher, B. E., Wanji, S., & Taylor, M. J. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-53 · Cited by 43 · see citing works
Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host
Albers, A., Esum, M. E., Tendongfor, N., Enyong, P., Klarmann‐Schulz, U., Wanji, S., Hoerauf, A. M., & Pfarr, K. M. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-12 · Cited by 42 · see citing works
Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection
Herrick, J. A., Legrand, F., Gounoue, R. K., Nchinda, G., Montavon, C., Bopda, J. G., Tchana, S. M., Ondigui, B. E., Nguluwe, K., Fay, M. P., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix016 · Cited by 42 · see citing works
Relative Bioavailability of Liquid and Tablet Formulations of the Antiparasitic Moxidectin
Korth-Bradley, J. M., Parks, V., Patat, A. A., Matschke, K. T., Mayer, P. R., & Fleckenstein, L. L. (2012) · Clinical Pharmacology in Drug Development · doi:10.1177/2160763x11432508 · Cited by 41 · see citing works
In vitro and in vivo interaction of moxidectin with BCRP/ABCG2
Pérez, M., Blazquez, A. G., Real, R., Mendoza, G., Prieto, J. G., Merino, G., & Álvarez, A. I. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.02.009 · Cited by 40 · see citing works
Insights from Community Case Management Data in Six Sub-Saharan African Countries
Laínez, Y. B., Wittcoff, A., Mohamud, A. I., Amendola, P., Perry, H. B., & d’Harcourt, E. (2012) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2012.12-0106 · Cited by 40 · see citing works
Anti-Wolbachia therapy for onchocerciasis & lymphatic filariasis
Sulaiman, W. A. W., Tatuene, J. K., Mohamed, M. H., Ramachandran, V., Ching, S. M., Lim, S. M. S., Hashim, H. Z., Mat, L. N. I., Hoo, F. K., & Basri, H. (2019) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_454_17 · Cited by 35 · see citing works
The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial
Korth-Bradley, J. M., Parks, V., Chalon, S., Gourley, I. S., Matschke, K. T., Cailleux, K., Fitoussi, S., & Fleckenstein, L. L. (2012) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2012.11-0415 · Cited by 33 · see citing works
Assessment of P-glycoprotein gene expression in adult stage of Haemonchus contortus in vivo exposed to ivermectin
Maté, L., Ballent, M., Cantón, C., Ceballos, L., Lifschitz, A., Lanusse, C., Alvarez, L., & Lirón, J. P. (2018) · Veterinary Parasitology · doi:10.1016/j.vetpar.2018.10.011 · Cited by 31 · see citing works
In vitro Metabolism of 14C-Moxidectin by Hepatic Microsomes from Various Species
Dupuy, J., Escudero, E., Eeckhoutte, C., Sutra, J. F., Galtier, P., & Alvinerie, M. (2001) · Veterinary Research Communications · doi:10.1023/a:1010686508307 · Cited by 30 · see citing works
Moxidectin has a lower neurotoxic potential but comparable brain penetration in P‐glycoprotein‐deficient CF‐1 mice compared to ivermectin
JANKO, C., & Geyer, J. (2012) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2012.01424.x · Cited by 30 · see citing works
Programmatic factors associated with the limited impact of Community-Directed Treatment with Ivermectin to control Onchocerciasis in three drainage basins of South West Cameroon
Duamor, C. T., Datchoua-Poutcheu, F. R., Ndongmo, W. P. C., Yoah, T. A., Njukang, E., Kah, E., Maingeh, M. S., Kengne-Ouafo, J. A., Tayong, D. B., Enyong, P., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005966 · Cited by 29 · see citing works
Implementation of test-and-treat with doxycycline and temephos ground larviciding as alternative strategies for accelerating onchocerciasis elimination in an area of loiasis co-endemicity: the COUNTDOWN consortium multi-disciplinary study protocol
Wanji, S., Nji, T. M., Hamill, L. C., Dean, L., Ozano, K., Njouendou, A. J., Abong, R. A., Obie, E. D., Beng, A. A., Ekanya, R., et al. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3826-8 · Cited by 29 · see citing works
Does onchocerciasis transmission take place in hypoendemic areas? a study from the North Region of Cameroon
Katabarwa, M. N., Eyamba, A., Chouaïbou, M., Enyong, P., Kuété, T., Yaya, S., Yougouda, A., Baldiagaï, J., Madi, K., Andze, G. O., et al. (2010) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2010.02501.x · Cited by 28 · see citing works
First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences
Verdú, J. R., Cortez, V., Martínez‐Pinna, J., Ortiz, A. J., Lumaret, J., Lobo, J. M., Sánchez‐Piñero, F., & Numa, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33241-0 · Cited by 28 · see citing works
Transitioning from river blindness control to elimination: steps toward stopping treatment
Cantey, P. T., Roy, S. L., Boakye, D. A., Mwingira, U., Ottesen, E. A., Hopkins, A., & Sodahlon, Y. (2018) · International Health · doi:10.1093/inthealth/ihx049 · Cited by 27 · see citing works
Hypo-endemic onchocerciasis hotspots: defining areas of high risk through micro-mapping and environmental delineation
Kelly‐Hope, L. A., Unnasch, T. R., Stanton, M. C., & Molyneux, D. H. (2015) · Infectious Diseases of Poverty · doi:10.1186/s40249-015-0069-6 · Cited by 25 · see citing works
Estimation of absolute oral bioavailability of moxidectin in dogs using a semi‐simultaneous method: influence of lipid co‐administration
Lallemand, E. A., Lespine, A., Alvinerie, M., Bousquet‐mélou, A., & Toutain, P. (2007) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2007.00878.x · Cited by 25 · see citing works
Economic evaluations of onchocerciasis interventions: a systematic review and research needs
Turner, H. C., Walker, M., Pion, S. D. S., McFarland, D. A., Bundy, D. A. P., & Basáñez, M.-G. (2019) · Tropical Medicine & International Health · doi:10.1111/tmi.13241 · Cited by 22 · see citing works
Effect of a Single Standard Dose (150–200 μg/kg) of Ivermectin onLoa loaMicrofilaremia: Systematic Review and Meta-analysis
Pion, S. D. S., Mbougua, J. B. T., Chesnais, C. B., Kamgno, J., Gardon, J., Chippaux, J., Ranque, S., Ernould, J.-C., Garcia, A., & Boussinesq, M. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz019 · Cited by 21 · see citing works
Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects
Korth-Bradley, J. M., Parks, V., Wagner, F. D., Chalon, S., Gourley, I. S., Matschke, K. T., Gossart, S., Ripp, S. L., & Fleckenstein, L. L. (2013) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.81 · Cited by 20 · see citing works
Agonist enhancement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus
Forrester, S. G., Beech, R. N., & Prichard, R. K. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.08.047 · Cited by 19 · see citing works
Drug Safety
Brody, T. (2016) · Clinical Trials · doi:10.1016/b978-0-12-804217-5.00025-4 · Cited by 18 · see citing works
Immunohistological studies on macrophages in lymph nodes of onchocerciasis patients after treatment with ivermectin
Knab, J., Darge, K., & Büttner, D. W. (1997) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1997.d01-217.x · Cited by 17 · see citing works
Evaluation of the Cardiac Safety of Long‐Acting Endectocide Moxidectin in a Randomized Concentration‐ QT Study
Kinrade, S. A., Mason, J. W., Sanabria, C. R., Rayner, C. R., Bullock, J. M., Stanworth, S. H., & Sullivan, M. T. (2018) · Clinical and Translational Science · doi:10.1111/cts.12583 · Cited by 16 · see citing works
Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models
Verma, M., Pathak, M., Shahab, M., Singh, K., Mitra, K., & Misra‐Bhattacharya, S. (2014) · Folia Parasitologica · doi:10.14411/fp.2014.068 · Cited by 11 · see citing works
Field-based evidence of single and few doses of annual ivermectin treatment efficacy in eliminating skin microfilaria load after a decade of intervention
Osue, H. O. (2017) · Ethiopian Journal of Health Sciences · doi:10.4314/ejhs.v27i2.5 · Cited by 8 · see citing works
The efficacy of rifapentine plus moxifloxacin against onchocerciasis: a randomized, open label pilot trial.
Klarmann‐Schulz, U., & Debrah, A. Y. (2015) · http://isrctn.com/ · doi:10.1186/isrctn43697583 · Cited by 2 · see citing works

Flagged first, then by citations

1 of the 111 references couldn’t be matched to a known paper.

Sorted by citations

Mechanical Strain and Bone Cell Function: A Review
Ehrlich, P. J., & Lanyon, L. E. (2002) · Osteoporosis International · doi:10.1007/s001980200095 · Cited by 509 · see citing works
Molecular Mechanisms Controlling the Fibrotic Repair Phenotype in Cornea: Implications for Surgical Outcomes
Stramer, B. M., Zieske, J. D., Jung, J., Austin, J. S., & Fini, M. E. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-1188 · Cited by 222 · see citing works
New global targets for NTDs in the WHO roadmap 2021–2030
Casulli, A. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009373 · Cited by 198 · see citing works
Evidence of bias affecting the interpretation of the results of local anaesthetic nerve blocks when assessing lameness in horses
Arkell, M., Archer, R. M., Guitián, J., & May, S. A. (2006) · Veterinary Record · doi:10.1136/vr.159.11.346 · Cited by 173 · see citing works
Drugs that target early stages of Onchocerca volvulus: A revisited means to facilitate the elimination goals for onchocerciasis
Jawahar, S., Tricoche, N., Bulman, C. A., Sakanari, J. A., & Lustigman, S. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009064 · Cited by 141 · see citing works
Announcements
Payne, R. C., Crompton, R. H., Isler, K., Savage, R., Vereecke, E., Gunther, M. M., Thorpe, S. K. S., & D’Août, K. (2006) · Journal of Anatomy · doi:10.1111/j.1469-7580.2006.00563.x · Cited by 130 · see citing works
Scabies: epidemiology, diagnosis, and treatment
Sunderkötter, C. H., Wohlrab, J., & Hamm, H. (2021) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2021.0296 · Cited by 123 · see citing works
Mycoplasmas associated with canine infectious respiratory disease
Chalker, V. J. (2004) · Microbiology · doi:10.1099/mic.0.26848-0 · Cited by 112 · see citing works
Theileria (Babesia) equi and Babesia caballi Infections in Horses in Galicia, Spain
Camacho, Á. T., Guitián, J., Pallas, E. P., Gestal, J. J., Olmeda, A. S., Habela, M., Telford, S. R., & Spielman, A. (2005) · Tropical Animal Health and Production · doi:10.1007/s11250-005-5691-z · Cited by 101 · see citing works
DrugCentral 2023 extends human clinical data and integrates veterinary drugs
Avram, S., Wilson, T. B., Curpan, R., Halip, L., Borota, A., Bora, A., Bologa, C. G., Holmes, J., Knockel, J., Yang, J. J., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac1085 · Cited by 101 · see citing works
Strongyloidiasis
Gordon, C. A., Utzinger, J., Muhi, S., Becker, S. L., Keiser, J., Khieu, V., & Gray, D. J. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00490-x · Cited by 81 · see citing works
DNA vaccination against bovine viral diarrhoea virus induces humoral and cellular responses in cattle with evidence for protection against viral challenge
Nobiron, I. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00745-4 · Cited by 80 · see citing works
Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five
Stegemann, S., Moreton, C., Svanbäck, S., Box, K. J., Motte, G., & Paudel, A. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103344 · Cited by 81 · see citing works
Natural product-derived compounds in clinical trials and drug approvals
Butler, M. S., Capon, R. J., Blaskovich, M. A. T., & Henderson, I. R. (2025) · Natural Product Reports · doi:10.1039/d5np00031a · Cited by 77 · see citing works
GABAergic signaling as a potential therapeutic target in cancers
Yang, Y., Ren, L., Li, W., Zhang, Y., Zhang, S., Ge, B., Yang, H., Du, G., Tang, B., Wang, H., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114410 · Cited by 66 · see citing works
Matrix metabolism rate differs in functionally distinct tendons
Birch, H. L., Worboys, S., EISSA, S., JACKSON, B., Strassburg, S., & Clegg, P. (2007) · Matrix Biology · doi:10.1016/j.matbio.2007.10.004 · Cited by 62 · see citing works
Natural Products That Changed Society
Christensen, S. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050472 · Cited by 61 · see citing works
A surgical tendonitis model in horses: Technique, clinical, ultra-sonographic and histological characterisation
Hunter, S. A., Campbell, N. B., Blikslager, A. T., Smith, R., & Schramme, M. C. A. (2010) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.3415/vcot-09-10-0106 · Cited by 61 · see citing works
Factors affecting the survival of sheep embryos after transfer within a MOET program
Bari, F. Y. (2003) · Theriogenology · doi:10.1016/s0093-691x(02)01162-7 · Cited by 55 · see citing works
What lies behind the curtain: Cryptic diversity in helminth parasites of human and veterinary importance
Chaves-González, L. E., Morales-Calvo, F., Mora, J., Solano-Barquero, A., Verocai, G. G., & Rojas, A. (2022) · Current Research in Parasitology and Vector-Borne Diseases · doi:10.1016/j.crpvbd.2022.100094 · Cited by 51 · see citing works
Synthetic Routes to Approved Drugs Containing a Spirocycle
Moshnenko, N., Kazantsev, A., Chupakhin, E. G., Bakulina, O., & Dar’in, D. V. (2023) · Molecules · doi:10.3390/molecules28104209 · Cited by 51 · see citing works
Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK
Cust, A. E., Harland, M., Makalic, E., Schmidt, D. F., Dowty, J. G., Aitken, J. F., Agha‐Hamilton, C., Armstrong, B. K., Barrett, J. H., Chan, M., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.086538 · Cited by 49 · see citing works
Rates and risk factors for contagious disease and mortality in young dairy heifers.
Johnson, K., Burn, C. C., & Wathes, D. C. (2012) · CABI Reviews · doi:10.1079/pavsnnr20116059 · Cited by 40 · see citing works
Anthelmintics in the environment: Their occurrence, fate, and toxicity to non-target organisms
Vokřál, I., Podlipná, R., Matoušková, P., & Skálová, L. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140446 · Cited by 39 · see citing works
The Kinematics of Load Carrying in Humans and Great Apes: Implications for the Evolution of Human Bipedalism
Watson, J., Payne, R., Chamberlain, A. T., Jones, R. K., & Sellers, W. I. (2009) · Folia Primatologica · doi:10.1159/000258646 · Cited by 39 · see citing works
Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model
Risch, F., Ritter, M., Hoerauf, A. M., & Hübner, M. P. (2021) · Parasitology Research · doi:10.1007/s00436-020-07026-2 · Cited by 38 · see citing works
Onchocerciasis: Current knowledge and future goals
Frallonardo, L., Gennaro, F. D., Panico, G. G., Novara, R., Pallara, E., Cotugno, S., Guido, G., Vita, E. D., Ricciardi, A., Totaro, V., et al. (2022) · Frontiers in Tropical Diseases · doi:10.3389/fitd.2022.986884 · Cited by 36 · see citing works
What does the COVID-19 pandemic mean for the next decade of onchocerciasis control and elimination?
Hamley, J. I. D., Blok, D. J., Walker, M., Milton, P., Hopkins, A., Hamill, L. C., Downs, P., de Vlas, S. J., Stolk, W. A., & Basáñez, M.-G. (2020) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/traa193 · Cited by 36 · see citing works
Cationic polymers that enhance the performance of HbsAg DNA in vivo
Bos, G. W., Kanellos, T., Crommelin, D. J. A., Hennink, W. E., & Howard, C. R. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.06.020 · Cited by 36 · see citing works
Microbial cross-contamination by airborne dispersion and contagion during defeathering of poultry
Allen, V. M., Hinton, M. H., Tinker, D. B., Gibson, C., Mead, G. C., & Wathes, C. M. (2003) · British Poultry Science · doi:10.1080/00071660310001616183 · Cited by 36 · see citing works
Amplified fragment length polymorphism analyses of Eimeria spp.: an improved process for genetic studies of recombinant parasites
Blake, D. P., Smith, A. L., & Shirley, M. W. (2003) · Parasitology Research · doi:10.1007/s00436-003-0890-x · Cited by 33 · see citing works
Evidence of seroconversion to SBV in camelids
Jack, C., Anstaett, O. L., Adams, J. T., Noad, R. J., Brownlie, J., & Mertens, P. (2012) · Veterinary Record · doi:10.1136/vr.e3939 · Cited by 32 · see citing works
Onchocerciasis drug development: from preclinical models to humans
Ngwewondo, A., Scandale, I., & Specht, S. (2021) · Parasitology Research · doi:10.1007/s00436-021-07307-4 · Cited by 32 · see citing works
Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?
Kura, K., Milton, P., Hamley, J. I. D., Walker, M., Bakajika, D. K., Kanza, E. M., Opoku, N. O., Howard, H., Nigo, M. M., Asare, S., et al. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0277 · Cited by 29 · see citing works
The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase
Movahedzadeh, F. (2004) · Microbiology · doi:10.1099/mic.0.27204-0 · Cited by 29 · see citing works
Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells
Kumar, N. D., ter Ellen, B. M., Bouma, E. M., Troost, B., van de Pol, D. P. I., van der Ende-Metselaar, H. H., van Gosliga, D., Apperloo, L., Carpaij, O. A., van den Berge, M., et al. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01543-21 · Cited by 28 · see citing works
Heat Shock Protein 27 Overexpression Mitigates Cytokine-Induced Islet Apoptosis and Streptozotocin-Induced Diabetes
Dai, T., Chamberlin, M. P., Natarajan, R. D., Todorov, I., Ma, J., LaPage, J. A., Phillips, L. M., Nast, C. C., Becerra, D., Chuang, P. Y., et al. (2009) · Endocrinology · doi:10.1210/en.2008-0732 · Cited by 29 · see citing works
Comparison of the effects of dietary n−3 and n−6 polyunsaturated fatty acids on very-low-density lipoprotein secretion when delivered to hepatocytes in chylomicron remnants
Zheng, X., Avella, M., & Botham, K. M. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570481 · Cited by 28 · see citing works
Spontaneous Septic Arthritis of Canine Elbows: Twenty-One Cases
Mielke, B., Comerford, E. J., English, K., & Meeson, R. (2018) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.1055/s-0038-1668108 · Cited by 28 · see citing works
The pipeline for drugs for control and elimination of neglected tropical diseases: 1. Anti-infective drugs for regulatory registration
Pfarr, K. M., Krome, A. K., Al-Obaidi, I., Batchelor, H. K., Vaillant, M., Hoerauf, A. M., Opoku, N. O., & Kuesel, A. C. (2023) · Parasites & Vectors · doi:10.1186/s13071-022-05581-4 · Cited by 29 · see citing works
A review on oxime functionality: an ordinary functional group with significant impacts in supramolecular chemistry
Tarai, A., & Nath, B. (2024) · Chemical Communications · doi:10.1039/d4cc01397b · Cited by 27 · see citing works
The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis
Risch, F., Kazakov, A., Specht, S., Pfarr, K. M., Fischer, P., Hoerauf, A. M., & Hübner, M. P. (2024) · Trends in Parasitology · doi:10.1016/j.pt.2024.07.005 · Cited by 27 · see citing works
Equine disease surveillance
Slater, J. D. (2014) · Veterinary Record · doi:10.1136/vr.g4982 · Cited by 27 · see citing works
Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: a focus on the children.
Colebunders, R., Kaiser, C. A., Basáñez, M.-G., Olliaro, P., Lakwo, T., & Fodjo, J. N. S. (2022) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2022.01.042 · Cited by 25 · see citing works
Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis
Ehrens, A., Hoerauf, A. M., & Hübner, M. P. (2022) · PubMed Central · doi:10.3205/id000079 · Cited by 25 · see citing works
Ivermectin and moxidectin against soil-transmitted helminth infections
Hürlimann, E., Hofmann, D., & Keiser, J. (2023) · Trends in Parasitology · doi:10.1016/j.pt.2023.01.009 · Cited by 27 · see citing works
Epoxy putty external skeletal fixation for fractures of the four main metacarpal and metatarsal bones in cats and dogs
Emmerson, T. D., Moores, A. P., Pead, M. J., & de la Puerta, B. (2008) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.3415/vcot-07-08-0080 · Cited by 25 · see citing works
An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease
Tyagi, R., Bulman, C. A., Cho‐Ngwa, F., Fischer, C., Marcellino, C., Arkin, M. R., McKerrow, J. H., McNamara, C. W., Mahoney, M. W., Tricoche, N., et al. (2021) · Pathogens · doi:10.3390/pathogens10010071 · Cited by 20 · see citing works
A double‐blind placebo‐controlled trial of an evening primrose and fish oil combination vs. hydrogenated coconut oil in the management of recurrent seasonal pruritus in horses
Craig, J. M., Lloyd, D. H., & Jones, C. P. R. D. (1997) · Veterinary Dermatology · doi:10.1046/j.1365-3164.1997.d01-11.x · Cited by 19 · see citing works
Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides
Wilson, D. M., Driedger, D., Liu, D. Y., Keerthisinghe, S., Hermann, A., Bieniossek, C., Linington, R. G., & Britton, R. (2024) · Nature Communications · doi:10.1038/s41467-024-46721-x · Cited by 17 · see citing works
Ocular Pharmacology
Novack, G. D., & Robin, A. L. (2024) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.2451 · Cited by 17 · see citing works
Development of a recombinant vaccine against human onchocerciasis
Abraham, D., Graham‐Brown, J., Carter, D., Gray, S. A., Hess, J. A., Makepeace, B. L., & Lustigman, S. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1977125 · Cited by 17 · see citing works
Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy cattle by culture and serology
Glanemann, B., Hoelzle, L. E., Bögli‐Stuber, K., Jemmi, T., & Wittenbrink, M. M. (2004) · Schweizer Archiv für Tierheilkunde · doi:10.1024/0036-7281.146.9.409 · Cited by 17 · see citing works
Scaling of sensorimotor control in terrestrial mammals
More, H. L., Weber, D. J., Hutchinson, J. R., Aung, S., Collins, D. F., & Donelan, J. M. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.04.510 · Cited by 17 · see citing works
Molecular and cellular analysis of embryonic avian tongue development
Huang, R., Lang, E., Otto, W. R., Christ, B., & Patel, K. (2001) · Anatomy and Embryology · doi:10.1007/s004290100196 · Cited by 17 · see citing works
Food Restriction Reverses the Hyper-Muscular Phenotype and Force Generation Capacity Deficit of the Myostatin Null Mouse
Matsakas, A., Romanello, V., Sartori, R., Masiero, E., Macharia, R., Otto, A., Elashry, M. I., Sandri, M., & Patel, K. (2012) · International Journal of Sports Medicine · doi:10.1055/s-0032-1312605 · Cited by 16 · see citing works
The avermectin/milbemycin receptors of parasitic nematodes
Wolstenholme, A. J., & Neveu, C. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.105010 · Cited by 13 · see citing works
Chylomicron-remnant-like particles modify production of vasoactive mediators by endothelial cells
Evans, M., Berhane, Y., Botham, K. M., Elliott, J., & Wheeler-Jones, C. P. D. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320110 · Cited by 13 · see citing works
Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin
Ekpo, U. F., Eneanya, O. A., Nwankwo, E. N., Soneye, I. Y., Weil, G. J., Fischer, P., & Nwaorgu, O. C. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07811-7 · Cited by 12 · see citing works
Locomotion, lameness and mobility in dairy cows
Bell, N. J., & Huxley, J. N. (2009) · Veterinary Record · doi:10.1136/vr.164.23.726 · Cited by 12 · see citing works
The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform
Freitas, L. T., Khan, M. A., Uddin, A., Halder, J. B., Singh-Phulgenda, S., Raja, D., Balakrishnan, V., Harriss, E., Rahi, M., Brack, M., et al. (2024) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011882 · Cited by 11 · see citing works
Pulmonary edema at recovery after colic operation with in-situ nasogastric tube in a horse
Veres‐Nyéki, K. O., Graubner, C., Aloisio, F., & Spadavecchia, C. (2011) · Schweizer Archiv für Tierheilkunde · doi:10.1024/0036-7281/a000232 · Cited by 12 · see citing works
Zoonotic skin disease in small animals
Chitty, J. R., & Hendricks, A. (2007) · In Practice · doi:10.1136/inpract.29.2.92 · Cited by 11 · see citing works
Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2
Kaji, M. D., Noonan, J. D., Geary, T. G., & Beech, R. N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112380 · Cited by 10 · see citing works
Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis
Luu, L., Bah, G. S., Okah-Nnane, N. H., Hartley, C. S., Glover, A. F., Walsh, T. R., Lian, L., Zhan, B., Bottazzi, M. E., Abraham, D., et al. (2022) · Vaccines · doi:10.3390/vaccines10060861 · Cited by 10 · see citing works
Tropical parasitic itch in returned travellers and immigrants from endemic areas
Ju, T., Does, A. V., Ingrasci, G., Norton, S. A., & Yosipovitch, G. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18408 · Cited by 10 · see citing works
Anatomical Imaging
Endo, H., & Frey, R. (2008) · Springer eBooks · doi:10.1007/978-4-431-76933-0 · Cited by 10 · see citing works
Unraveling the therapeutic landscape of approved non-peptide macrocycles
Li, Z., Zhang, Z., & Yu, B. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.021 · Cited by 10 · see citing works
Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dependent on their uptake by the low density lipoprotein receptor
Graham, V., Maggio, P. D., Armengol, S., Lawson, C., Wheeler-Jones, C. P. D., & Botham, K. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.11.008 · Cited by 9 · see citing works
Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa
Cheke, R., Little, K. E., Young, S. S., Walker, M., & Basáñez, M.-G. (2021) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2021.01.002 · Cited by 8 · see citing works
Supporting Drug Development for Neglected Tropical Diseases Using Mathematical Modeling
Walker, M., Hamley, J. I. D., Milton, P., Monnot, F., Kinrade, S. A., Specht, S., Pedrique, B., & Basáñez, M.-G. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab350 · Cited by 8 · see citing works
The aerodynamic forces and pressure distribution of a revolving pigeon wing
Usherwood, J. R. (2010) · Springer eBooks · doi:10.1007/978-3-642-11633-9_33 · Cited by 8 · see citing works
Current Status on 1,4-Dihydropyridine Derivatives against Human Pathogenic Parasites
Elso, O. G., Liñares, G. G., & Sülsen, V. P. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221104162901 · Cited by 7 · see citing works
Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms
Hamed, M. A., Surakat, O. A., Ekundina, V. O., Jimoh, K. B., Adeogun, A. E., Akanji, N. O., Babalola, O. J., & Eya, C. P. (2025) · Journal of Tropical Medicine · doi:10.1155/jotm/2126664 · Cited by 7 · see citing works
Characterising the skeletal muscle histological phenotype of the DeltaE50-MD dog, a preclinical model of Duchenne muscular dystrophy
Hildyard, J. C. W., Rawson, F., Harron, R. C. M., Riddell, D. O., Massey, C., Taylor‐Brown, F., Wells, D. J., & Piercy, R. J. (2018) · Neuromuscular Disorders · doi:10.1016/s0960-8966(18)30342-0 · Cited by 7 · see citing works
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Wyss, M. T., Heuer, C., & Herwerth, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386405 · Cited by 7 · see citing works
Progress towards elimination of onchocerciasis transmission in Mali: A “pre-stop MDA” survey in 18 transmission zones
Dolo, H., Coulibaly, M. E., Sow, M., Coulibaly, Y. I., Doumbia, M. N., Sangare, M. B., Sanogo, A., Dembélé, B., Guindo, B., Coulibaly, M. B., et al. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011632 · Cited by 7 · see citing works
An Updated Economic Assessment of Moxidectin Treatment Strategies for Onchocerciasis Elimination
Turner, H. C., Kura, K., Roth, B., Kuesel, A. C., Kinrade, S. A., & Basáñez, M.-G. (2024) · Clinical Infectious Diseases · doi:10.1093/cid/ciae054 · Cited by 7 · see citing works
Recognising and controlling risk factors for antimicrobial resistance
Lloyd, H. (2010) · Schweizer Archiv für Tierheilkunde · doi:10.1024/0036-7281/a000031 · Cited by 7 · see citing works
Handling and veterinary care of British bats
Bexton, S., & Couper, D. (2010) · In Practice · doi:10.1136/inp.c2899 · Cited by 7 · see citing works
A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients
Bousquet‐mélou, A., Lespine, A., Sutra, J., Bargues, I., & Toutain, P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.666348 · Cited by 6 · see citing works
The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation
Wood, N., Smith, D., Kinrade, S. A., Sullivan, M. T., Rayner, C. R., WESCHE, D. L., Patel, K., & Rowland‐Yeo, K. (2024) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0012351 · Cited by 6 · see citing works
Radiology of thoracic trauma in the dog and cat
PARRY, A. T., & Lamb, C. (2010) · In Practice · doi:10.1136/inp.c2901 · Cited by 6 · see citing works
Comparison between Hemilaminectomy with either Anulectomy or Partial Discectomy for Treatment of Thoracolumbar Intervertebral Disc Protrusion in Dogs
Decker, S. D., & Crawford, A. H. (2018) · Veterinary and Comparative Orthopaedics and Traumatology · doi:10.1055/s-0038-1639590 · Cited by 6 · see citing works
Evaluation of the symmetric model for myosin-linked regulation: effect of site-directed mutations in the regulatory light chain on scallop myosin
Colegrave, M., Patel, H., Offer, G., & Chantler, P. D. (2003) · Biochemical Journal · doi:10.1042/bj20030404 · Cited by 6 · see citing works
Decamethonium bromide-mediated inhibition of embryonic muscle development
Macharia, R., McKinnell, I. W., Christ, B., Patel, K., & Otto, W. R. (2004) · Anatomy and Embryology · doi:10.1007/s00429-003-0362-1 · Cited by 6 · see citing works
Safety and Short-term Efficacy of a Single Dose of 2 mg Moxidectin in Loa loa–Infected Individuals: A Double-Blind, Randomized Ivermectin-Controlled Trial With Ascending Microfilarial Densities
Wafeu, G. S., Lepage, T. M., Campillo, J. T., Efon-Ekangouo, A., Nana-Djeunga, H. C., Nzune-Toche, N., Domché, A., Sumo, L., Njitchouang, G.-R., Tsasse, M. A. F., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae240 · Cited by 5 · see citing works
Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia
Gokool, S., Townson, S., Freeman, A., Siemienski-Kleyn, J., Zubrzycki, J., Tagboto, S. K., Hübner, M. P., & Scandale, I. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020210 · Cited by 5 · see citing works
Keeping it legal: delegation to veterinary nurses
Branscombe, L. (2012) · In Practice · doi:10.1136/inp.d7818 · Cited by 5 · see citing works
Necrosis from needlestick injury with live Actinobacillus pleuropneumoniae porcine vaccine
Rycroft, A. N., Assavacheep, P., Jacobs, M., & Langford, P. R. (2011) · BMJ · doi:10.1136/bmj.d6261 · Cited by 5 · see citing works
Equine CCL11 induces eosinophil cytoskeletal reorganization and activation
Weston, M. C., Collins, M. E., & Cunningham, F. M. (2006) · Inflammation Research · doi:10.1007/s00011-005-0007-3 · Cited by 5 · see citing works
Repurposed Drugs That Activate Autophagy in Filarial Worms Act as Effective Macrofilaricides
Voronin, D., Tricoche, N., Peguero, R., Kaminska, A. M., Ghedin, E., Sakanari, J. A., & Lustigman, S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020256 · Cited by 4 · see citing works
Determination and Correlation of Moxidectin Solubility in Aqueous Cosolvents of Methanol, Ethanol, Isopropanol, and Ethylene Glycol
Huang, C., & Xu, R. (2022) · Journal of Chemical & Engineering Data · doi:10.1021/acs.jced.1c00517 · Cited by 4 · see citing works
Moxidectin versus Ivermectin in the prevention and treatment of acute and chronic experimental trichinellosis
Elmehy, D. A., Gamea, G. A., El-Guindy, D. M., Tahoon, D. M., Elkholy, R. A., & Zoghroban, H. S. (2024) · Experimental Parasitology · doi:10.1016/j.exppara.2024.108775 · Cited by 4 · see citing works
Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation
Dommann, J., Keiser, J., Garneau, J. R., Gandelin, A., Casanova, C., Keller, P. M., Sayasone, S., Vonaesch, P., & Schneeberger, P. H. H. (2024) · Communications Biology · doi:10.1038/s42003-024-07135-z · Cited by 4 · see citing works
Preface
Anderson, D. E., & Whitehead, C. E. (2009) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/j.cvfa.2009.03.008 · Cited by 4 · see citing works
Efficacy and safety of moxidectin and albendazole compared to ivermectin and albendazole co-administration in adolescents infected with Trichuris trichiura: a randomized controlled trial protocol
Welsche, S., Mrimi, E. C., Keller, L., Hürlimann, E., Hofmann, D., Hattendorf, J., Ali, S. M., & Keiser, J. (2021) · Gates Open Research · doi:10.12688/gatesopenres.13299.2 · Cited by 4 · see citing works
Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon
Kang, T. R., Dinga, J. N., Orock, A. E., Monya, E., & Ngemenya, M. N. (2022) · Journal of Parasitology Research · doi:10.1155/2022/1663330 · Cited by 4 · see citing works
Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges
Mackenzie, C. D., Souza, A. A., & Geary, T. G. (2022) · doi:10.1002/9783527823413.ch5 · Cited by 4 · see citing works

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data
Turner, H. C., Walker, M., Attah, S. K., Opoku, N. O., Awadzi, K., Kuesel, A. C., & Basáñez, M.-G. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-0779-4 · Cited by 194 · see citing works
Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?
Kura, K., Milton, P., Hamley, J. I. D., Walker, M., Bakajika, D. K., Kanza, E. M., Opoku, N. O., Howard, H., Nigo, M. M., Asare, S., et al. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0277 · Cited by 29 · see citing works
An Updated Economic Assessment of Moxidectin Treatment Strategies for Onchocerciasis Elimination
Turner, H. C., Kura, K., Roth, B., Kuesel, A. C., Kinrade, S. A., & Basáñez, M.-G. (2024) · Clinical Infectious Diseases · doi:10.1093/cid/ciae054 · Cited by 7 · see citing works
Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial
Opoku, N. O., Bakajika, D. K., Kanza, E. M., Howard, H., Mambandu, G., Nyathirombo, A., Nigo, M. M., Kasonia, K., Masembe, S. L., Mumbere, M., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32844-1 · Cited by 298 · see citing works
Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Onchocerciasis
(2019) · Case Medical Research · doi:10.31525/ct1-nct03876262 · Cited by 125 · see citing works

Authors: Milton, P., Hamley, J. I. D., Walker, M., & Basáñez, M.-G.
Affiliations: London Centre for Neglected Tropical Disease Research (GB)
Royal Veterinary College (GB)
London Centre for Neglected Tropical Disease Research and MRC Centre for Global Infectious Disease Analysis (MRC GIDA), Department of Infectious Disease Epidemiology, Imperial College London, London, UK
ORCID: Milton, Philip
Hamley, Jonathan I. D.
Walker, Martin
Venue: Expert Review of Anti-infective Therapy
Publisher: Informa UK Limited
Published: 2020-07-26
Volume: 18
Issue: 11
Pages: 1067-1081
ISSN: 1478-7210 (ISSN-L)
1744-8336
DOI: 10.1080/14787210.2020.1792772
OpenAlex: W3044273225
Cited by: 211
References: 111
Citations by year: 2026: 7 · 2025: 9 · 2024: 21 · 2023: 14 · 2022: 17 · 2021: 17 · 2020: 1 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 5 · 2012: 9
FWCI: 1.61
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified, 104 d)
Locations: Expert Review of Anti-infective Therapy (publishedVersion, cc-by)
PubMed (publishedVersion)
RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
Spiral (Imperial College London) (submittedVersion, other-oa)
Funders: Medical Research Council Doctoral Training Program
Topics: Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords: moxidectin, onchocerciasis, ivermectin, mass drug administration, onchocerciasis elimination, safety and tolerability, regulatory status, pediatric formulations, community-directed treatment
MeSH terms: Mass Drug Administration, Administration, Oral, Animals, Anthelmintics, Humans, Ivermectin, Onchocerciasis, Macrolides, Disease Eradication

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Moxidectin: an oral treatment for human onchocerciasis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks