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The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin
Abstract
The in vitro and in vivo activities of catheters coated with minocycline and rifampin and with chlorhexidine gluconate and silver sulfadiazine were evaluated. When incubated in serum at 37 degrees C, the half-life of the inhibitory activity of catheters coated with minocycline and rifampin was 25 days compared with 3 days for catheters coated with chlorhexidine gluconate and silver sulfadiazine. In a rabbit model, catheters coated with minocycline and rifampin were significantly more efficacious than catheters coated with chlorhexidine and silver sulfadiazine in preventing colonization and infection with Staphylococcus aureus (P < .05). Catheters coated with minocycline and rifampin demonstrated broad-spectrum in vitro inhibitory activity against gram-positive bacteria, gram-negative bacteria, and Candida albicans that was significantly superior to the inhibitory activity of catheters coated with chlorhexidine gluconate and silver sulfadiazine (P < .01). Minocycline and rifampin were also highly efficacious in preventing colonization and infection in vivo.
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Cited by
Guidelines for the Prevention of Intravascular Catheter-related Infections
O'Grady, N. P., Alexander, M., Burns, L. A., Dellinger, E. P., Garland, J., Heard, S. O., Lipsett, P. A., Masur, H., Mermel, L. A., Pearson, M. L., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir257 · Cited by 4,699
Self-citationDental biofilms: difficult therapeutic targets
SOCRANSKY, S. S., & HAFFAJEE, A. D. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280102.x · Cited by 1,273
A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters
Darouiche, R. O., Raad, I. I., Heard, S. O., Thornby, J. I., Wenker, O. C., Gabrielli, A., Berg, J., Khardori, N., Hanna, H., Hachem, R., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400101 · Cited by 804
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Metadata
- Authors
- Raad, I., Darouiche, R., Hachem, R., Mansouri, M., & Bodey, G. P.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-02-01
- Volume
- 173
- Issue
- 2
- Pages
- 418-424
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2142314945
- Cited by
- 249
- References
- 0
- FWCI
- 41.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin. https://app.cochat.ai/papers/10.1093/infdis/173.2.418
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- Raad, I., Darouiche, R., Hachem, R., Mansouri, M., & Bodey, G. P. (1996). The Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/173.2.418
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
