The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters
Open accessAbstract
BACKGROUND: The use of central venous catheters impregnated with either minocycline and rifampin or chlorhexidine and silver sulfadiazine reduces the rates of catheter colonization and catheter-related bloodstream infection as compared with the use of unimpregnated catheters. We compared the rates of catheter colonization and catheter-related bloodstream infection associated with these two kinds of antiinfective catheters. METHODS: We conducted a prospective, randomized clinical trial in 12 university-affiliated hospitals. High-risk adult patients in whom central venous catheters were expected to remain in place for three or more days were randomly assigned to undergo insertion of polyurethane, triple-lumen catheters impregnated with either minocycline and rifampin (on both the luminal and external surfaces) or chlorhexidine and silver sulfadiazine (on only the external surface). After their removal, the tips and subcutaneous segments of the catheters were cultured by both the roll-plate and the sonication methods. Peripheral-blood cultures were obtained if clinically indicated. RESULTS: Of 865 catheters inserted, 738 (85 percent) produced culture results that could be evaluated. The clinical characteristics of the patients and the risk factors for infection were similar in the two groups. Catheters impregnated with minocycline and rifampin were 1/3 as likely to be colonized as catheters impregnated with chlorhexidine and silver sulfadiazine (28 of 356 catheters [7.9 percent] vs. 87 of 382 [22.8 percent], P<0.001), and catheter-related bloodstream infection was 1/12 as likely in catheters impregnated with minocycline and rifampin (1 of 356 [0.3 percent], vs. 13 of 382 [3.4 percent] for those impregnated with chlorhexidine and silver sulfadiazine; P<0.002). CONCLUSIONS: The use of central venous catheters impregnated with minocycline and rifampin is associated with a lower rate of infection than the use of catheters impregnated with chlorhexidine and silver sulfadiazine.
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Cites
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically
Ferraro, M. J. (2000) · Medical Entomology and Zoology · Cited by 17,210
A Semiquantitative Culture Method for Identifying Intravenous-Catheter-Related Infection
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Self-citation(1996) · American Journal of Infection Control · doi:10.1016/s0196-6553(96)90058-9 · Cited by 492
Heard, S. O., Wagle, M., Vijayakumar, E., McLean, S., Brueggemann, A., Napolitano, L. M., Edwards, L. P., O'Connell, F. M., Puyana, J. C., & Doern, G. V. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.1.81 · Cited by 473
Self-citationInfectious Complications of Indwelling Vascular Catheters
Raad, I. I., & Bodey, G. P. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/15.2.197 · Cited by 446
Self-citationSherertz, R. J., Raad, I. I., Belani, A., Koo, L. C., Rand, K. H., Pickett, D. L., Straub, S. A., & Fauerbach, L. L. (1990) · Journal of Clinical Microbiology · doi:10.1128/jcm.28.1.76-82.1990 · Cited by 381
Self-citationThe Broad-Spectrum Activity and Efficacy of Catheters Coated with Minocycline and Rifampin
Raad, I., Darouiche, R., Hachem, R., Mansouri, M., & Bodey, G. P. (1996) · Journal of Infectious Diseases · doi:10.1093/infdis/173.2.418 · Cited by 249
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Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
Donlan, R. M., & Costerton, J. W. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.167-193.2002 · Cited by 6,644
Guidelines for the Prevention of Intravascular Catheter-related Infections
O'Grady, N. P., Alexander, M., Burns, L. A., Dellinger, E. P., Garland, J., Heard, S. O., Lipsett, P. A., Masur, H., Mermel, L. A., Pearson, M. L., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir257 · Cited by 4,699
Self-citationBiofilm Formation: A Clinically Relevant Microbiological Process
Donlan, R. M. (2001) · Clinical Infectious Diseases · doi:10.1086/322972 · Cited by 1,343
Bacterial silver resistance: molecular biology and uses and misuses of silver compounds
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Dental biofilms: difficult therapeutic targets
SOCRANSKY, S. S., & HAFFAJEE, A. D. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280102.x · Cited by 1,273
Metadata
- Authors
- Darouiche, R. O., Raad, I. I., Heard, S. O., Thornby, J. I., Wenker, O. C., Gabrielli, A., Berg, J., Khardori, N., Hanna, H., Hachem, R., Harris, R. L., & Mayhall, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-01-07
- Volume
- 340
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2325546012
- Cited by
- 804
- References
- 16
- FWCI
- 102.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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