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Placental Transfer and Maternally Acquired Neonatal IgG Immunity in Human Immunodeficiency Virus Infection
Open accessAbstract
Transplacental transfer of specific IgG antibodies was studied in 46 pairs of human immunodeficiency virus type 1 (HIV-1)-seropositive women and their neonates and in 53 pairs of healthy HIV-seronegative mothers and their newborns. Neonatal and maternal sera were assessed by nephelometry for total levels of serum IgG and by ELISA for IgG antibodies to herpes simplex virus (HSV), varicella-zoster virus (VZV), measles virus, tetanus toxoid, streptolysin O, and Streptococcus pneumoniae capsular antigens. Placental transfer of IgG antibodies to VZV, tetanus toxoid, measles, streptolysin O, and S. pneumoniae was decreased by maternal HIV infection. Maternal levels of total IgG had an independent effect on transfer of antibodies to HSV, VZV, measles, and S. pneumoniae. Neonatal antibody levels to tetanus toxoid, measles, and S. pneumoniae were significantly lower in the HIV group. Both maternal hypergammaglobulinemia and maternal HIV infection may contribute to these low antibody levels at birth and thus lead to early infection in this high-risk population.
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Cited by
IgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
Self-citationThe Sick Placenta—The Role of Malaria
Brabin, B. J., Romagosa, C., Abdelgalil, S., Menéndez, C., Verhoeff, F. H., McGready, R., Fletcher, K. A., Owens, S., d'Alessandro, U., Nosten, F., et al. (2004) · Placenta · doi:10.1016/j.placenta.2003.10.019 · Cited by 375
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Titanji, K. (2006) · Blood · doi:10.1182/blood-2005-11-013383 · Cited by 293
The therapeutic age of the neonatal Fc receptor
Pyzik, M., Kozicky, L. K., Gandhi, A. K., & Blumberg, R. S. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00821-1 · Cited by 288
HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination
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Metadata
- Authors
- Isabel de Moraes-Pinto, M., Almeida, A. C. M., Kenj, G., Filgueiras, T. E., Tobias, W., Santos, A. M. N., Carneiro-Sampaio, M. M. S., Farhat, C. K., Milligan, P. J. M., Johnson, P. M., & Hart, C. A.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-05-01
- Volume
- 173
- Issue
- 5
- Pages
- 1077-1084
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2129578219
- Cited by
- 182
- References
- 0
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Isabel de Moraes-Pinto, M., Almeida, A. C. M., Kenj, G., Filgueiras, T. E., Tobias, W., Santos, A. M. N., Carneiro-Sampaio, M. M. S., Farhat, C. K., Milligan, P. J. M., Johnson, P. M., & Hart, C. A. (1996). Placental Transfer and Maternally Acquired Neonatal IgG Immunity in Human Immunodeficiency Virus Infection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/173.5.1077
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