The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
Abstract
Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients. We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4+ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initiated early in infection. This may have important consequences for the response of HIV-infected patients to immunizations.
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Cites
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Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system
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HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
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Cited by
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Ancuta, P., Kamat, A., Kunstman, K. J., Kim, E.-Y., Autissier, P., Wurcel, A., Zaman, T., Stone, D., Mefford, M., Morgello, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002516 · Cited by 499
Xu, W., Santini, P. A., Sullivan, J. S., He, B., Shan, M., Ball, S. C., Dyer, W. B., Ketas, T. J., Chadburn, A., Cohen-Gould, L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1753 · Cited by 302
Marginal Zone B-Cells, a Gatekeeper of Innate Immunity
Zouali, M., & Richard, Y. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00063 · Cited by 112
Metadata
- Authors
- Titanji, K.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-05-09
- Volume
- 108
- Issue
- 5
- Pages
- 1580-1587
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2162633432
- Cited by
- 293
- References
- 33
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
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