The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High Prevalence of GB Virus C Infection in a Group of Italian Patients with Hepatitis of Unknown Etiology
Abstract
Prevalence of the recently discovered GB virus C(GBV-C) was evaluated in a cohort of 49 Italian patients with acute or chronic hepatitis of unknown etiology (non-A-E hepatitis) and in a control group of 100 healthy blood donors. The GBV-C genomes could be detected by polymerase chain reaction (PCR) with reverse transcription in 35% of the acute and 39% of the chronic hepatitis patients; only 1 of the control subjects had a positive response. All PCR products hybridized with a specific probe in a colorimetric assay, and the analysis of the sequences of the amplified cDNAs fully confirmed the specificity of the assay. Furthermore, the alignment of the predicted translation products identified two recurrent amino acid substitutions in 6 patients, suggesting the possible existence of at least 2 different GBV-C subtypes. Thus, GBV-C may be an important agent, contributing, at least in Italy, to a significant number of the cases of hepatitis of unknown etiology.
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Citations
Cites
The Natural History of Community-Acquired Hepatitis C in the United States
Alter, M. J., Margolis, H. S., Krawczynski, K., Judson, F. N., Mares, A., Alexander, W. J., Hu, P. Y., Miller, J. K., Gerber, M. A., Sampliner, R. E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272702 · Cited by 1,592
Cited by
Acute Non-A–E Hepatitis in the United States and the Role of Hepatitis G Virus Infection
Alter, M. J., Gallagher, M., Morris, T. T., Moyer, L. A., Meeks, E. L., Krawczynski, K., Kim, J. P., & Margolis, H. S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703133361101 · Cited by 409
Chu, C. M., Lin, S., Hsieh, S., Yeh, C., Lin, D., Sheen, I., & Liaw, Y. (1999) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199906)58:2<154::aid-jmv9>3.0.co;2-e · Cited by 32
Metadata
- Authors
- Fiordalisi, G., Zanella, I., Mantero, G., Bettinardi, A., Stellini, R., Paraninfo, G., Cadeo, G., & Primi, D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-07-01
- Volume
- 174
- Issue
- 1
- Pages
- 181-183
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2155517838
- Cited by
- 162
- References
- 1
- FWCI
- 28.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fiordalisi, G., Zanella, I., Mantero, G., Bettinardi, A., Stellini, R., Paraninfo, G., Cadeo, G., & Primi, D. (1996). High Prevalence of GB Virus C Infection in a Group of Italian Patients with Hepatitis of Unknown Etiology. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/174.1.181
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.