The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Density of Helicobacter pylori Infection In Vivo as Assessed by Quantitative Culture and Histology
Abstract
Helicobacter pylori density was assessed by quantitative culture and histologic examination of gastric biopsy specimens from 29 H. pylori-infected dyspeptic patients. Density was correlated with cagA and vacA genotypes (assessed by polymerase chain reaction and colony hybridization), gastric inflammation and epithelial injury (assessed histologically), and peptic ulceration. Quantitative culture was more reproducible than histology, and antral density was more reproducible than corpus density. Mean antral density of cagA+/vacA sl strains was 4-fold higher than that of cagA-/vacA s2 strains (1.9 X 10(6) vs. 4.5 x 10(5) cfu/g, P = .02). Antral density was associated with mucosal neutrophilic and lymphocytic infiltration (P < .01) and with epithelial injury (P < .05). Mean antral bacteria] density was 5-fold higher in duodenal ulcer patients than in others (P = .005). In conclusion, H. pylori density in vivo is easily quantified and is associated with bacterial virulence determinants, gastric inflammation, and duodenal ulceration, suggesting a central role in pathogenesis.
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STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965
Practical Statistics for Medical Research
Altman, D. G. (1990) · doi:10.1201/9780429258589 · Cited by 10,668
Cited by
Helicobacter pylori Virulence and Genetic Geography
Covacci, A., Telford, J. L., Giudice, G. D., Parsonnet, J., & Rappuoli, R. (1999) · Science · doi:10.1126/science.284.5418.1328 · Cited by 1,049
Persistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Atherton, J. C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100125 · Cited by 567
Self-citationNorwalk Virus Infection and Disease Is Associated with ABO Histo–Blood Group Type
Hutson, A. M., Atmar, R. L., Graham, D. Y., & Estes, M. K. (2002) · The Journal of Infectious Diseases · doi:10.1086/339883 · Cited by 487
Ermak, T. H., Giannasca, P. J., Nichols, R., Myers, G. A., Nedrud, J., Weltzin, R., Lee, C. K., Kleanthous, H., & Monath, T. P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2277 · Cited by 375
Metadata
- Authors
- Atherton, J. C., Tham, K. T., Peek, R. M., Cover, T. L., & Blaser, M. J.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-09-01
- Volume
- 174
- Issue
- 3
- Pages
- 552-556
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2084198623
- Cited by
- 185
- References
- 2
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Atherton, J. C., Tham, K. T., Peek, R. M., Cover, T. L., & Blaser, M. J. (1996). Density of Helicobacter pylori Infection In Vivo as Assessed by Quantitative Culture and Histology. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/174.3.552
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