The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Current Capabilities of Gut Microbiome–Based Diagnostics and the Promise of Clinical Application
Open accessAbstract
There is increasing evidence for the importance of the gut microbiome in human health and disease. Traditional and modern technologies - from cell culture to next generation sequencing - have facilitated these advances in knowledge. Each of the tools employed in measuring the microbiome exhibits unique capabilities that may be leveraged for clinical diagnostics. However, much still needs to be done to standardize the language and metrics by which a microbiome is characterized. Here we review the capabilities of gut microbiome-based diagnostics, review selected examples, and discuss the outlook towards clinical application.
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It is extremely difficult to identify gut microbiota configurations with the required specificity and reproducibility for clinical practice.
“This makes it extremely difficult to identify gut microbiota configurations with the required specificity and reproducibility for clinical practice 24 .”
From Human microbiome myths and misconceptions (2023) · cites this paper as [24]
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Flagged first, then by citations
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Cited by
Sorted by citations
Next-generation sequencing: insights to advance clinical investigations of the microbiome
Wensel, C. R., Pluznick, J. L., Salzberg, S. L., & Sears, C. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154944 · Cited by 437
Human microbiome myths and misconceptions
Walker, A. W., & Hoyles, L. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01426-7 · Cited by 163
Metadata
- Authors
- Damhorst, G. L., Adelman, M. W., Woodworth, M. H., & Kraft, C. S.
- Affiliations
- Emory University (US)
- Corresponding author
- Kraft, Colleen S
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-12-17
- Volume
- 223
- Issue
- Supplement_3
- Pages
- S270-S275
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC8206793
- OpenAlex
- W3113545051
- Cited by
- 47
- References
- 11
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 11 · 2023: 4 · 2022: 6 · 2021: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (UM1AI104681, K23AI144036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, microbiome-based diagnostics, clinical application, next-generation sequencing, cell culture
- MeSH terms
- Gastrointestinal Microbiome, Humans, Computational Biology, Clinical Laboratory Techniques, Metagenomics, High-Throughput Nucleotide Sequencing
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