Cited by 267Viral Infections and Immunology ResearchVaccine Coverage and HesitancyVirology and Viral Diseases

Vaccine-associated paralytic poliomyelitis: a review of the epidemiology and estimation of the global burden

Open access
Platt, L. R., Estivariz, C. F., Sutter, R. W.·2014·Journal of Infectious Diseases

Abstract

BACKGROUND: Vaccine-associated paralytic poliomyelitis (VAPP) is a rare adverse event associated with oral poliovirus vaccine (OPV). This review summarizes the epidemiology and provides a global burden estimate. METHODS: A literature review was conducted to abstract the epidemiology and calculate the risk of VAPP. A bootstrap method was applied to calculate global VAPP burden estimates. RESULTS: Trends in VAPP epidemiology varied by country income level. In the low-income country, the majority of cases occurred in individuals who had received >3 doses of OPV (63%), whereas in middle and high-income countries, most cases occurred in recipients after their first OPV dose or unvaccinated contacts (81%). Using all risk estimates, VAPP risk was 4.7 cases per million births (range, 2.4-9.7), leading to a global annual burden estimate of 498 cases (range, 255-1018). If the analysis is limited to estimates from countries that currently use OPV, the VAPP risk is 3.8 cases per million births (range, 2.9-4.7) and a burden of 399 cases (range, 306-490). CONCLUSIONS: Because many high-income countries have replaced OPV with inactivated poliovirus vaccine, the VAPP burden is concentrated in lower-income countries. The planned universal introduction of inactivated poliovirus vaccine is likely to substantially decrease the global VAPP burden by 80%-90%.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/infdis/jiu184

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [14]Population Division, Department of Economic and Social Affairs, United Nations. World Population Prospects: The 2010 Revision, CD-ROM Edition, 2011.

Cited by

Sorted by citations

Authors
Platt, L. R., Estivariz, C. F., & Sutter, R. W.
Affiliations
World Health Organization (CH)
Venue
Journal of Infectious Diseases
Published
2014-10-14
Volume
210
Issue
suppl 1
Pages
S380-S389
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2103683759
Cited by
267
References
46
Citations by year
2026: 13 · 2025: 23 · 2024: 22 · 2023: 19 · 2022: 17 · 2021: 20 · 2020: 26 · 2019: 22 · 2018: 31 · 2017: 21 · 2016: 25 · 2015: 24 · 2014: 3
FWCI
3.92
Type
journal article
Language
en
Open access
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • World Health Organization
  • National Institutes of Health (CC999999)
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
vaccine-associated paralytic poliomyelitis, oral polio vaccine, vaccine adverse events, epidemiology, inactivated poliovirus vaccine, low-income countries, vaccine safety
MeSH terms
Adolescent, Adult, Child, Child, Preschool, Developing Countries, Female, Humans, Infant, Infant, Newborn, Male, Poliomyelitis, Global Health, Prevalence, Risk Assessment, Developed Countries, Poliovirus Vaccines, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review