The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development
Open accessAbstract
Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-specific immunity against S. pyogenes to emm-cluster based immunity for this bacterium should be further investigated. Implementation of this emm-cluster-based system as a standard typing scheme for S. pyogenes will facilitate the design of future studies of M protein function, streptococcal virulence, epidemiological surveillance, and vaccine development.
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Cites
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Self-citationCriscuolo, A., & Gribaldo, S. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-210 · Cited by 1,633
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Cited by
Streptococcus pyogenes adhesion and colonization
Brouwer, S., Barnett, T. C., Rivera‐Hernandez, T., Rohde, M., & Walker, M. J. (2016) · FEBS Letters · doi:10.1002/1873-3468.12254 · Cited by 113
“As such, a large number of functions, and interactions with host molecules, have been ascribed to different M protein variants [140-143].”
Background
Metadata
- Authors
- Sanderson-Smith, M., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., & Smeesters, P. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-05-05
- Volume
- 210
- Issue
- 8
- Pages
- 1325-1338
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2103458678
- Cited by
- 317
- References
- 39
- FWCI
- 29.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Sanderson-Smith, M., De Oliveira, D. M. P., Guglielmini, J., McMillan, D. J., Vu, T., Holien, J. K., Henningham, A., Steer, A. C., Bessen, D. E., Dale, J. B., Curtis, N., Beall, B. W., Walker, M. J., Parker, M. W., Carapetis, J. R., Van Melderen, L., Sriprakash, K. S., & Smeesters, P. R. (2014). A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiu260
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
