The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia
Open accessAbstract
BACKGROUND: The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. METHODS: P. falciparum infections from artesunate efficacy trials in Bangladesh, Cambodia, Laos, Myanmar, and Vietnam were genotyped at 33 716 genome-wide single-nucleotide polymorphisms (SNPs). Linear mixed models were used to test associations between parasite genotypes and parasite clearance half-lives following artesunate treatment. K13 mutations were tested for association with artemisinin resistance, and extended haplotypes on chromosome 13 were examined to determine whether mutations arose focally and spread or whether they emerged independently. RESULTS: The presence of nonreference K13 alleles was associated with prolonged parasite clearance half-life (P = 1.97 × 10(-12)). Parasites with a mutation in any of the K13 kelch domains displayed longer parasite clearance half-lives than parasites with wild-type alleles. Haplotype analysis revealed both population-specific emergence of mutations and independent emergence of the same mutation in different geographic areas. CONCLUSIONS: K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia. While we found some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar.
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MethodInfluentialArtemisinin Resistance in Plasmodium falciparum Malaria
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Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
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Self-citationA molecular marker of artemisinin-resistant Plasmodium falciparum malaria
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Self-citationTun, K. M., Imwong, M., Lwin, K. M., Win, A. A., Hlaing, T. M., Hlaing, T., Lin, K., Kyaw, M. P., Plewes, K., Faiz, M. A., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70032-0 · Cited by 414
Self-citationAmato, R., Lim, P., Miotto, O., Amaratunga, C., Dek, D., Pearson, R. D., Almagro-Garcia, J., Neal, A. T., Sreng, S., Suon, S., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30409-1 · Cited by 401
Self-citationMolecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Wicht, K. J., Mok, S., & Fidock, D. A. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115546 · Cited by 322
Nayak, S., Peto, T. J., Kucharski, M., Tripura, R., Callery, J. J., Quang Huy, D. T., Gendrot, M., Lek, D., Nghia, H. D. T., van der Pluijm, R. W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54915-6 · Cited by 15
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Metadata
- Authors
- Takala-Harrison, S., Jacob, C. G., Arze, C., Cummings, M. P., Silva, J. C., Dondorp, A. M., Fukuda, M. M., Hien, T. T., Mayxay, M., Noedl, H., Nosten, F., Kyaw, M. P., Nhien, N. T. T., Imwong, M., Bethell, D., Se, Y., Lon, C., Tyner, S. D., Saunders, D. L., Ariey, F., Mercereau-Puijalon, O., Menard, D., Newton, P. N., Khanthavong, M., Hongvanthong, B., Starzengruber, P., Fuehrer, H.-P., Swoboda, P., Khan, W. A., Phyo, A. P., Nyunt, M. M., Nyunt, M. H., Brown, T. S., Adams, M., Pepin, C. S., Bailey, J., Tan, J. C., Ferdig, M. T., Clark, T. G., Miotto, O., MacInnis, B., Kwiatkowski, D. P., White, N. J., Ringwald, P., & Plowe, C. V.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-09-01
- Volume
- 211
- Issue
- 5
- Pages
- 670-679
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2104700616
- Cited by
- 422
- References
- 26
- FWCI
- 54.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Takala-Harrison, S., Jacob, C. G., Arze, C., Cummings, M. P., Silva, J. C., Dondorp, A. M., Fukuda, M. M., Hien, T. T., Mayxay, M., Noedl, H., Nosten, F., Kyaw, M. P., Nhien, N. T. T., Imwong, M., Bethell, D., Se, Y., Lon, C., Tyner, S. D., Saunders, D. L., . . . Plowe, C. V. (2015). Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiu491
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