CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch
Open accessAbstract
M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.
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CCL20 is considered crucial for M-cell differentiation and regulates lymphocyte recruitment via CCL20-CCR6.
“Additionally, CCL20 is regarded as a crucial chemokine for M-cell differentiation and regulates lymphocyte recruitment in a CCL20-CCR6 dependent manner [38].”
From Characterization of Vibrio cholerae neuraminidase as an immunomodulator for novel formulation of oral allergy immunotherapy (2018) · cites this paper as [38]
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- Authors
- Ebisawa, M., Hase, K., Takahashi, D., Kitamura, H., Knoop, K. A., Williams, I. R., & Ohno, H.
- Affiliations
- RIKEN (JP)
- Nagoya City University (JP)
- Emory University (US)
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-21
- Volume
- 23
- Issue
- 4
- Pages
- 261-269
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- PMC
- PMC3140262
- OpenAlex
- W2151401863
- Cited by
- 57
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (20113003)
- Mitsubishi Foundation
- Japan Science Society
- Japan Society for the Promotion of Science (20790383, 18790343, 22689017, 21390155, 21790334)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064730)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Peyer's patches, CCR6, CD11c, B cells, CCL20, follicle-associated epithelium, chemotactic migration, adoptive transfer
- MeSH terms
- Animals, B-Lymphocytes, Cell Differentiation, Cell Movement, Cells, Cultured, Epithelial Cells, Mice, Inbred C57BL, Peyer's Patches, Lymphocyte Subsets, Mice, Knockout, Adoptive Transfer, CD11c Antigen, Mice, Receptors, CCR6, Chemokine CCL20
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