Cited by 64RNA Research and SplicingRNA regulation and diseaseCytokine Signaling Pathways and Interactions

Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells

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Maeda, Kazuhiko, Akira, Shizuo·2017·International Immunology

Abstract

Current studies using knockout mice have revealed that some Cys–Cys–Cys–His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system.

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  • Regnase-1 degrades IL-6 mRNA, while Arid5a protects IL-6 mRNA from Regnase-1-mediated degradation.

    “Regnase-1 degrades IL-6 mRNA (87), while Arid5a protects IL-6 mRNA from Regnase-1-mediated degradation (88).”

    From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [87]

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Authors
Maeda, K., & Akira, S.
Affiliations
Immunology Frontier Research Center, The University of Osaka (JP)
Corresponding author
Akira, Shizuo
Venue
International Immunology
Published
2017-03-27
Volume
29
Issue
4
Pages
149-155
ISSN
  • 0953-8178 (ISSN-L)
  • 1460-2377
OpenAlex
W2602505844
Cited by
64
References
73
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 14 · 2022: 9 · 2021: 14 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 2
FWCI
0.36
Type
journal article
Language
en
Open access
Locations
  • International Immunology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science
  • National Institutes of Health (5P01AI070167)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
mRNA stability, tristetraprolin, Roquin, Regnase-1, RNA-binding proteins, RNA metabolism, immune regulation, immune homeostasis, knockout mice
MeSH terms
Animals, Humans, Immune System, Immunity, Ribonucleases, RNA, Messenger, Transcription Factors, RNA-Binding Proteins, RNA Stability, Ubiquitin-Protein Ligases, Tristetraprolin, Immunomodulation

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