The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Sphingosine 1-phosphate and inflammation
Open accessAbstract
AbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory processes. S1P is enriched in blood and lymph while maintained low in intracellular or interstitial fluids, creating a steep S1P gradient that is utilized to facilitate efficient egress of lymphocytes from lymphoid organs. Blockage of the S1P-S1P receptor signaling system results in a marked decrease in circulating lymphocytes because of a failure of lymphocyte egress from lymphoid organs. This provides a basis of immunomodulatory drugs targeting S1P1 receptor such as FTY720, an immunosuppressive drug approved in 2010 as the first oral treatment for relapsing–remitting multiple sclerosis. The S1P-S1P receptor signaling system also plays important roles in maintenance of vascular integrity since it suppresses sprouting angiogenesis and regulates vascular permeability. Dysfunction of the S1P-S1P receptor signaling system results in various vascular defects, such as exaggerated angiogenesis in developing retina and augmented inflammation due to increased permeability. Endothelial-specific deletion of S1P1 receptor in mice fed high-fat diet leads to increased formation of atherosclerotic lesions. This review highlights the importance of the S1P-S1P receptor signaling system in inflammatory processes. We also describe our recent findings regarding a specific S1P chaperone, apolipoprotein M, that anchors to high-density lipoprotein and contributes to shaping the endothelial-protective and anti-inflammatory properties of high-density lipoprotein.
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Cites
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
Kappos, L., Radue, E.-W., O'Connor, P., Polman, C., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909494 · Cited by 2,644
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
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Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
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Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
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The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
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Self-citationAn Overview of Sphingolipid Metabolism: From Synthesis to Breakdown
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Self-citationMultiple Sclerosis: Current Knowledge and Future Outlook
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Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
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Cited by
Morris, G., Puri, B. K., Bortolasci, C. C., Carvalho, A., Berk, M., Walder, K., Moreira, E. G., & Maes, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.037 · Cited by 84
Metadata
- Authors
- Obinata, H., & Hla, T.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-04-11
- Volume
- 31
- Issue
- 9
- Pages
- 617-625
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2936762825
- Cited by
- 268
- References
- 76
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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