The DOI matches its Crossref record.
Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance
Abstract
Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications
Tshibangu-Kabamba, E., & Yamaoka, Y. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00449-x · Cited by 517
Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications
Gerrits, M. M., van Vliet, A. H., Kuipers, E. J., & Kusters, J. G. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70627-2 · Cited by 329
Antibiotic resistance in : Implications for therapy
GRAHAM, D. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70100-3 · Cited by 300
Translation and Protein Synthesis: Macrolides
Katz, L., & Ashley, G. W. (2005) · Chemical Reviews · doi:10.1021/cr030107f · Cited by 177
Dailidiene, D., Bertoli, M. T., Miciuleviciene, J., Mukhopadhyay, A. K., Dailide, G., Pascasio, M. A., Kupcinskas, L., & Berg, D. E. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.12.3940-3946.2002 · Cited by 101
Metadata
- Authors
- Versalovic, J.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-08-01
- Volume
- 40
- Issue
- 2
- Pages
- 283-286
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2170232574
- Cited by
- 195
- References
- 0
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. https://app.cochat.ai/papers/10.1093/jac/40.2.283
- The paper
- Versalovic, J. (1997). Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/40.2.283
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
