Translation and Protein Synthesis: Macrolides

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327 · see citing works

Inactivation of Antibiotics and the Dissemination of Resistance Genes

DAVIES, J. E. (1994) · Science · doi:10.1126/science.8153624 · Cited by 1,729 · see citing works

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

Schlünzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., & Franceschi, F. J. (2001) · Nature · doi:10.1038/35101544 · Cited by 1,057 · see citing works

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Donadio, S., Staver, M. J., McAlpine, J. B., et al. (1991) · Science · doi:10.1126/science.2024119 · Cited by 913 · see citing works

Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants

Roberts, M. C., Sutcliffe, J. A., Courvalin, P. M., Jensen, L. B., Rood, J. I., & Seppälä, H. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2823 · Cited by 874 · see citing works

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

Pfeifer, B. A., Admiraal, S. J., Gramajo, H. C., Cane, D. E., & Khosla, C. (2001) · Science · doi:10.1126/science.1058092 · Cited by 751 · see citing works

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

Scrutton, N. S., Berry, A., & Perham, R. N. (1990) · Nature · doi:10.1038/343038a0 · Cited by 733 · see citing works

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

Cortés, J., Haydock, S. F., Roberts, G. A., et al. (1990) · Nature · doi:10.1038/348176a0 · Cited by 636 · see citing works

Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system

Sutcliffe, J. A., Tait-Kamradt, A. G., & Wondrack, L. M. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1817 · Cited by 619 · see citing works

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

Piel, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222481399 · Cited by 609 · see citing works

The structures of four macrolide antibiotics bound to the large ribosomal subunit.

Hansen, J., Ippolito, J., Ban, N., Nissen, P., Moore, P., & Steitz, T. (2002) · Molecules and Cells · doi:10.1016/s1097-2765(02)00570-1 · Cited by 523 · see citing works

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

Versalovic, J. A., Shortridge, D., Kibler, K., Griffy, M. V., Beyer, J. M., Flamm, R. K., Tanaka, S., Graham, D. Y., & Go, M. F. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.477 · Cited by 501 · see citing works

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

McDaniel, R. N., Thamchaipenet, A., Gustafsson, C., Fu, H., Betlach, M. C., Betlach, M. C., & Ashley, G. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1846 · Cited by 463 · see citing works

Macrolide Resistance in<i>Treponema pallidum</i>in the United States and Ireland

Lukehart, S. A., Godornes, C., Molini, B. J., Sonnett, P., Hopkins, S., Mulcahy, F., Engelman, J., Mitchell, S. J., Rompalo, A. M., Marra, C. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040216 · Cited by 378 · see citing works

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

Cupp‐Vickery, J. R., & Poulos, T. L. (1995) · Nature Structural & Molecular Biology · doi:10.1038/nsb0295-144 · Cited by 372 · see citing works

Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases

Caffrey, P. (2003) · ChemBioChem · doi:10.1002/cbic.200300581 · Cited by 371 · see citing works

POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics

Katz, L., & Donadio, S. (1993) · Annual Review of Microbiology · doi:10.1146/annurev.mi.47.100193.004303 · Cited by 370 · see citing works

Inducible erythromycin resistance in staphlyococci is encoded by a member of the ATP‐binding transport super‐gene family

Ross, J. I., Eady, E. A., Cove, J. H., Cunliffe, W. J., Baumberg, S., & Wootton, J. C. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00696.x · Cited by 358 · see citing works

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae : Architecture of metabolic diversity

Xue, Y., Zhao, L., Liu, H., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12111 · Cited by 350 · see citing works

A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR‐like DNA‐binding fold

Wietzorrek, A., & Bibb, M. J. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.5421903.x · Cited by 346 · see citing works

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

Moazed, D., & Noller, H. F. (1987) · Biochimie · doi:10.1016/0300-9084(87)90215-x · Cited by 338 · see citing works

Dissecting and Exploiting Intermodular Communication in Polyketide Synthases

Gokhale, R. S., Tsuji, S. Y., Cane, D. E., et al. (1999) · Science · doi:10.1126/science.284.5413.482 · Cited by 323 · see citing works

Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 Oral Antimicrobial Agents Based on Pharmacodynamic Parameters: 1997 U.S. Surveillance Study

Jacobs, M. R., Bajaksouzian, S., Zilles, A., et al. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.8.1901 · Cited by 317 · see citing works

A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

Reid, R. C., Piagentini, M., Rodrı́guez, E., et al. (2002) · Biochemistry · doi:10.1021/bi0268706 · Cited by 311 · see citing works

Three different phenotypes of erythromycin-resistant Streptococcus pyogenes in Finland

Seppälä, H., Nissinen, A. E. T., Yu, Q., et al. (1993) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/32.6.885 · Cited by 295 · see citing works

The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA

Hansen, L. H., Mauvais, P., & Douthwaite, S. R. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01202.x · Cited by 292 · see citing works

Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage

Tait-Kamradt, A. G., Davies, T. A., Cronan, M. T., Jacobs, M. R., Appelbaum, P. C., & Sutcliffe, J. A. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.8.2118-2125.2000 · Cited by 281 · see citing works

A chain initiation factor common to both modular and aromatic polyketide synthases

Bisang, C., Long, P. F., Corte´s, J., Westcott, J., Crosby, J. C., Matharu, A., Cox, R. J., Simpson, T. J., Staunton, J., & Leadlay, P. F. (1999) · Nature · doi:10.1038/46829 · Cited by 278 · see citing works

The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection

Erah, P. O. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/39.1.5 · Cited by 277 · see citing works

Insights into erythromycin action from studies of its activity as inducer of resistance

Weisblum, B. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.4.797 · Cited by 267 · see citing works

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

Skinner, R. H., Cundliffe, E., & Schmidt, F. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44232-3 · Cited by 266 · see citing works

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

Cheng, Y., Tang, G.-L., & Shen, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0537286100 · Cited by 261 · see citing works

Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase

Jacobsen, J. R., Hutchinson, C. R., Cane, D. E., et al. (1997) · Science · doi:10.1126/science.277.5324.367 · Cited by 257 · see citing works

Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage

Cortés, J., Wiesmann, K. E. H., Roberts, G. A., et al. (1995) · Science · doi:10.1126/science.7770773 · Cited by 252 · see citing works

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases

Haydock, S. F., Aparicio, J. F., Molnár, I., et al. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01119-y · Cited by 243 · see citing works

Engineered Biosynthesis of a Complete Macrolactone in a Heterologous Host

Kao, C. M., Katz, L., & Khosla, C. (1994) · Science · doi:10.1126/science.8036492 · Cited by 229 · see citing works

Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase

Marsden, A. F. A., Wilkinson, B. M., Cortés, J., et al. (1998) · Science · doi:10.1126/science.279.5348.199 · Cited by 219 · see citing works

Diversity of Ribosomal Mutations Conferring Resistance to Macrolides, Clindamycin, Streptogramin, and Telithromycin in Streptococcus pneumoniae

Canu, A., Malbruny, B., Coquemont, M., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.1.125-131.2002 · Cited by 218 · see citing works

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

Tsai, S., Miercke, L. J. W., Krucinski, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011399198 · Cited by 217 · see citing works

Clinical Pharmacokinetics of Clarithromycin

Rodvold, K. A. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199937050-00003 · Cited by 214 · see citing works

Synthesis and Antibacterial Activity of Ketolides (6-O-Methyl-3-oxoerythromycin Derivatives): A New Class of Antibacterials Highly Potent Against Macrolide-Resistant and -Susceptible Respiratory Pathogens

Agouridas, C., Denis, A., Auger, J.-M., et al. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980240d · Cited by 200 · see citing works

Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens

Denis, A., Agouridas, C., Auger, J.-M., et al. (1999) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(99)00534-x · Cited by 196 · see citing works

Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae

Lucier, T. S., Heitzman, K., Liu, S. K., & Hu, P. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.12.2770 · Cited by 196 · see citing works

Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

Versalovic, J. A. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.2.283 · Cited by 196 · see citing works

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

Heathcote, M. L., Staunton, J., & Leadlay, P. F. (2001) · Chemistry & Biology · doi:10.1016/s1074-5521(01)00002-3 · Cited by 193 · see citing works

Alteration of the Substrate Specificity of a Modular Polyketide Synthase Acyltransferase Domain through Site-Specific Mutations

Reeves, C. D., Murli, S., Ashley, G. W., et al. (2001) · Biochemistry · doi:10.1021/bi015864r · Cited by 188 · see citing works

Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

Douthwaite, S. R., Hansen, L. H., & Mauvais, P. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01841.x · Cited by 187 · see citing works

A hybrid modular polyketide synthase obtained by domain swapping

Oliynyk, M., Brown, M. J. B., Cortés, J., et al. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90069-1 · Cited by 185 · see citing works

An erythromycin analog produced by reprogramming of polyketide synthesis.

Donadio, S., McAlpine, J. B., Sheldon, P. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7119 · Cited by 184 · see citing works

The Ketolides

Zhanel, G. G., Walters, M., Noreddin, A. M., et al. (2002) · Drugs · doi:10.2165/00003495-200262120-00006 · Cited by 183 · see citing works

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

Summers, R. G., Donadio, S., Staver, M. J., et al. (1997) · Microbiology · doi:10.1099/00221287-143-10-3251 · Cited by 180 · see citing works

Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus

Quirós, L. M., Aguirrezabalaga, I., Olano, C., Méndez, C., & Salas, J. A. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00880.x · Cited by 179 · see citing works

A‐factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus

Horinouchi, S., & Beppu, T. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01073.x · Cited by 178 · see citing works

Mutation in 23S rRNA Associated with Macrolide Resistance in Neisseria gonorrhoeae

Ng, L.-K., Martín, I., Liu, G., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.9.3020-3025.2002 · Cited by 177 · see citing works

Struktur und Biogenese der Makrolide

Woodward, R. B. (1957) · Angewandte Chemie · doi:10.1002/ange.19570690109 · Cited by 176 · see citing works

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

Harms, J., Schlünzen, F., Fucini, P., Bartels, H., & Yonath, A. (2004) · BMC Biology · doi:10.1186/1741-7007-2-4 · Cited by 170 · see citing works

Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins

Wittmann, H. G., Stöffler, G., Apirion, D., Rosen, L., Tanaka, K., Tamaki, M., Takata, R., Dekio, S., Otaka, E., & Osawa, S. (1973) · Molecular and General Genetics MGG · doi:10.1007/bf00333665 · Cited by 169 · see citing works

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

Xiong, L., Shah, S., Mauvais, P., et al. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01203.x · Cited by 169 · see citing works

The large linear plasmid pSLA2‐L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism

Mochizuki, S., Hiratsu, K., Suwa, M., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03523.x · Cited by 167 · see citing works

An Erythromycin Derivative Produced by Targeted Gene Disruption in Saccharopolyspora erythraea

Weber, J. M., Leung, J. O., Swanson, S., et al. (1991) · Science · doi:10.1126/science.2011746 · Cited by 166 · see citing works

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

Berisio, R., Harms, J. M., Schluenzen, F., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.14.4276-4279.2003 · Cited by 165 · see citing works

Genes and enzymes involved in deoxysugar biosynthesis in bacteria

Trefzer, A. C., Bechthold, A., Salas, J. A., et al. (1999) · Natural Product Reports · doi:10.1039/a804431g · Cited by 164 · see citing works

Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase

Marsden, A. F. A., Caffrey, P., Aparicio, J. F., et al. (1994) · Science · doi:10.1126/science.8278811 · Cited by 162 · see citing works

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

Haydock, S. F., Dowson, J. A., Dhillon, N., Roberts, G. A., Cortés, J., & Leadlay, P. F. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00290659 · Cited by 157 · see citing works

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes

Menninger, J. R., & Otto, D. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.5.811 · Cited by 153 · see citing works

Erythromycin, clarithromycin, and azithromycin: are the differences real?

Amsden, G. W. (1996) · Clinical Therapeutics · doi:10.1016/s0149-2918(96)80179-2 · Cited by 153 · see citing works

A multiplasmid approach to preparing large libraries of polyketides

Xue, Q., Ashley, G. W., Hutchinson, C. R., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11740 · Cited by 148 · see citing works

Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin.

Cane, D. E., & Yang, C. C. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00238a051 · Cited by 144 · see citing works

Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides

Wondrack, L. M., Massa, M. A., Yang, B. V., et al. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.4.992 · Cited by 139 · see citing works

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

Ruan, X., Pereda, A., Stassi, D. L., et al. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.20.6416-6425.1997 · Cited by 139 · see citing works

Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of Haemophilus influenzae Clinical Isolates

Perić, M., Bozdoğan, B., Jacobs, M. R., & Appelbaum, P. C. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.1017-1022.2003 · Cited by 138 · see citing works

Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNA

Garza‐Ramos, G., Xiong, L., Zhong, P., & Mankin, A. S. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6898-6907.2001 · Cited by 136 · see citing works

Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease

Nash, K. A., & Inderlied, C. B. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.12.2625 · Cited by 136 · see citing works

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

Stassi, D. L., Kakavas, S. J., Reynolds, K. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7305 · Cited by 133 · see citing works

Genetics of Streptomyces Fradiae and Tylosin Biosynthesis

Baltz, R. H., & Seno, E. T. (1988) · Annual Review of Microbiology · doi:10.1146/annurev.mi.42.100188.002555 · Cited by 133 · see citing works

Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae

Wilson, D. J., Xue, Y., Reynolds, K. A., et al. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.11.3468-3475.2001 · Cited by 129 · see citing works

Quantitative Analysis of the Relative Contributions of Donor Acyl Carrier Proteins, Acceptor Ketosynthases, and Linker Regions to Intermodular Transfer of Intermediates in Hybrid Polyketide Synthases

Wu, N., Cane, D. E., & Khosla, C. (2002) · Biochemistry · doi:10.1021/bi012086u · Cited by 128 · see citing works

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae

Xue, Y., Wilson, D. J., Zhao, L., et al. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90293-9 · Cited by 127 · see citing works

Comparative safety of the different macrolides

Rubinstein, E. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00397-1 · Cited by 124 · see citing works

Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases,

Tsai, S., Lu, H., Cane, D. E., et al. (2002) · Biochemistry · doi:10.1021/bi0260177 · Cited by 122 · see citing works

Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin

Arthur, M., Andremont, A., & Courvalin, P. M. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.3.404 · Cited by 121 · see citing works

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin

Poulsen, S. M., Kofoed, C. B., & Vester, B. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4229 · Cited by 121 · see citing works

Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

Baltz, R. H., & Seno, E. T. (1981) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.20.2.214 · Cited by 121 · see citing works

Evidence for a double-helical structure for modular polyketide synthases

Staunton, J., Caffrey, P., Aparicio, J. F., et al. (1996) · Nature Structural Biology · doi:10.1038/nsb0296-188 · Cited by 120 · see citing works

Need for Annual Surveillance of Antimicrobial Resistance in Streptococcus pneumoniae in the United States: 2-Year Longitudinal Analysis

Sahm, D. F., Karlowsky, J. A., Kelly, L. J., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.1037-1042.2001 · Cited by 120 · see citing works

Engineering Deoxysugar Biosynthetic Pathways from Antibiotic-Producing Microorganisms

Rodrı́guez, L., Aguirrezabalaga, I., Allende-Vega, N., et al. (2002) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00154-0 · Cited by 119 · see citing works

Characterisation and molecular cloning of the novel macrolide-streptogramin B resistance determinant from Staphylococcus epidermidis

Ross, J. I., Farrell, A. M., Eady, E. A., et al. (1989) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/24.6.851 · Cited by 119 · see citing works

Macrolide biosynthesis. Tylactone formation involves the processive addition of three carbon units

Yue, S., Duncan, J. S., Yamamoto, Y., et al. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00238a050 · Cited by 118 · see citing works

Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin

O'Hara, K., Kanda, T., Ohmiya, K., et al. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.8.1354 · Cited by 115 · see citing works

Biochemical Evidence for an Editing Role of Thioesterase II in the Biosynthesis of the Polyketide Pikromycin

Kim, B. S., Cropp, T. A., Beck, B. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207770200 · Cited by 114 · see citing works

Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis

Kakavas, S. J., Katz, L., & Stassi, D. L. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.23.7515-7522.1997 · Cited by 114 · see citing works

Site-Specific Mutations in the 23S rRNA Gene of Helicobacter pylori Confer Two Types of Resistance to Macrolide-Lincosamide-Streptogramin B Antibiotics

Wang, G., & Taylor, D. E. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.8.1952 · Cited by 113 · see citing works

Genetic analysis of erythromycin production in Streptomyces erythreus

Weber, J. M., Wierman, C. K., & Hutchinson, C. R. (1985) · Journal of Bacteriology · doi:10.1128/jb.164.1.425-433.1985 · Cited by 112 · see citing works

In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin

Barry, A. L., Jones, R. N., & Thornsberry, C. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.5.752 · Cited by 112 · see citing works

Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

Ma, Z., Clark, R. F., Brazzale, A., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0102349 · Cited by 112 · see citing works

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Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis : Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae

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Characterization of a Staphylococcal Plasmid Related to pUB110 and Carrying Two Novel Genes, vatC and vgbB , Encoding Resistance to Streptogramins A and B and Similar Antibiotics

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Skipping in a Hybrid Polyketide Synthase

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Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea

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L22 Ribosomal Protein and Effect of Its Mutation on Ribosome Resistance to Erythromycin

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Telithromycin: a new ketolide antimicrobial for treatment of respiratory tract infections

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The mycinose-biosynthetic genes of Streptomyces fradiae , producer of tylosin

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Novel mechanism for plasmid-mediated erythromycin resistance by pNE24 from Staphylococcus epidermidis

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Microbial Glycosylation of Macrolide Antibiotics by Streptomyces hygroscopicus ATCC 31080 and Distribution of a Macrolide Glycosyl Transferasein Several Streptomyces Strains.

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