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Cited by 342

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Application of fluoroquinolone pharmacodynamics

Wright, D. H.·2000·Journal of Antimicrobial Chemotherapy
DOI 10.1093/jac/46.5.669
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Abstract

Pharmacodynamics provides a rational basis for optimizing dosing regimens by describing the relationship between drug, host and antimicrobial effect. The successful identification of meaningful pharmacodynamic outcome parameters can, therefore, greatly assist clinicians in making objective prescribing decisions rather than relying on static in vitro MIC data. While pharmacodynamic outcome parameters have been proposed for select antimicrobial agents, their clinical application remains to be defined fully. Quinolone antibiotics are generally considered to have concentration-dependent bactericidal activity and peak/MIC and AUC/MIC ratios have been identified as possible pharmacodynamic predictors of clinical and microbiological outcome as well as the development of bacterial resistance. Investigators have suggested that AUC/MIC ratios of 100-125 or peak/MIC ratios of >10 are required to predict clinical and microbiological success and to limit the development of bacterial resistance. These conclusions are derived primarily from studies of Gram-negative bacteria, and recent data suggest that these ratios may not be applicable for Streptococcus pneumoniae, where an AUC/MIC ratio of <40 appears to be a more accurate predictor. There is considerable variation in pharmacodynamic calculations and outcome parameters appear to be quinolone- and pathogen-specific. Additional prospective clinical research is needed to characterize quinolone pharmacodynamic parameters and answer unresolved questions regarding optimal pharmacodynamic outcome predictors for Gram-positive bacteria, anaerobes and atypical respiratory pathogens.

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Metadata

Authors
Wright, D. H.
Venue
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press (OUP)
Published
2000-11-01
Volume
46
Issue
5
Pages
669-683
ISSN
  • 0305-7453 (ISSN-L)
  • 1460-2091
DOI
10.1093/jac/46.5.669
OpenAlex
W2152510108
Cited by
342
References
38
FWCI
6.81
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Application of fluoroquinolone pharmacodynamics. https://app.cochat.ai/papers/10.1093/jac/46.5.669
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Wright, D. H. (2000). Application of fluoroquinolone pharmacodynamics. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/46.5.669

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.