The DOI matches its Crossref record.
Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin
Abstract
The effects of mecillinam, trimethoprim and ciprofloxacin, antibiotics used in the treatment of urinary tract infections, on the aquatic environment were assessed. Mecillinam and ciprofloxacin were both readily biodegradable (primary degradation) in activated sludge, whereas trimethoprim persisted. The toxicity of these antibiotics towards sludge bacteria, a green alga, a cyanobacterium, a crustacean and a fish were investigated; both mecillinam and ciprofloxacin were highly toxic to the cyanobacterium Microcystis aeruginosa (EC50 in the range 5–60 Ìg/L). Risk characterization for the aquatic environment was performed for the three compounds by calculating the predicted environmental concentration (PEC) and the predicted no-effects concentration (PNEC). A PEC/PNEC ratio of <1 indicates that, with the present pattern of use, no environmental risk is expected. PEC/PNEC ratios of <1 for present usage in Europe were found for mecillinam and trimethoprim whereas a PEC/PNEC ratio >1 was found for ciprofloxacin.
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Citations
Cited by
Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment
Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2016.12.004 · Cited by 2,023
Xu, L., Zhang, H., Xiong, P., Zhu, Q., Liao, C., & Jiang, G. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141975 · Cited by 1,206
Pharmaceutical Industry Wastewater: Review of the Technologies for Water Treatment and Reuse
Gadipelly, C., Pérez-González, A., Yadav, G. D., Ortiz, I., Ibáñez, R., Rathod, V. K., & Marathe, K. V. (2014) · Industrial & Engineering Chemistry Research · doi:10.1021/ie501210j · Cited by 849
Fluoroquinolone antibiotics: An emerging class of environmental micropollutants
Van Doorslaer, X., Dewulf, J., Van Langenhove, H., & Demeestere, K. (2014) · Science of The Total Environment · doi:10.1016/j.scitotenv.2014.08.075 · Cited by 819
González-Pleiter, M., Gonzalo, S., Rodea-Palomares, I., Leganés, F., Rosal, R., Boltes, K., Marco, E., & Fernández-Piñas, F. (2013) · Water Research · doi:10.1016/j.watres.2013.01.020 · Cited by 783
Metadata
- Authors
- Halling-Sorensen, B.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 46
- Issue
- 90001
- Pages
- 53-58
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W4366736487
- Cited by
- 333
- References
- 0
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Halling-Sorensen, B. (2000). Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/46.suppl_1.53
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
