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Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines
Abstract
The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups. Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline, demeclocycline, lymecycline, methacycline and rolitetracycline is characterized by poor absorption after food. Group 2, represented by doxycycline and minocycline, is more reliably absorbed orally, while group 3, represented by the glycylcycline tigecycline, is injectable only, with an improved antibacterial spectrum compared with the tetracyclines. Though incompletely understood, the pharmacodynamic properties of the tetracyclines and glycylcyclines are summarized.
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Citations
Cited by
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad428 · Cited by 740
Moxidectin: an oral treatment for human onchocerciasis
Milton, P., Hamley, J. I. D., Walker, M., & Basáñez, M.-G. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1792772 · Cited by 211
Roberts, M. C., & Schwarz, S. (2016) · Journal of Environmental Quality · doi:10.2134/jeq2015.04.0207 · Cited by 192
Non-antibiotic properties of tetracyclines and their clinical application in dermatology
Perret, L. J., & Tait, C. P. (2014) · Australasian Journal of Dermatology · doi:10.1111/ajd.12075 · Cited by 68
Metadata
- Authors
- Agwuh, K. N.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05-30
- Volume
- 58
- Issue
- 2
- Pages
- 256-265
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2167293860
- Cited by
- 806
- References
- 0
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
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